Limited Evidence for Biological Adjuvants in Hindfoot Arthrodesis

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Dexter Seow ◽  
Youichi Yasui ◽  
John F. Dankert ◽  
Wataru Miyamoto ◽  
James D.F. Calder ◽  
...  
Keyword(s):  
Limited Evidence ◽  
Hindfoot Arthrodesis

The Excavation of a Settlement of the Later Bronze Age and Iron Age at Myrehead, Falkirk District

1983 ◽  
Vol 10 (1) ◽  
pp. 41-71 ◽  
Author(s):  
G J Barclay
Keyword(s):  
Bronze Age ◽  
Iron Age ◽  
Farming System ◽  
Activity Period ◽  
Limited Evidence ◽  
Ring Groove ◽  
Domestic Activity ◽  
First Millennium ◽  
First Millennium Bc ◽  
Actual Settlement

SUMMARY Myrehead has revealed the eroded remnants of activity from the Beaker period (Period A) onwards, with actual settlement evinced only from about the early first millennium be. The three houses and the cooking pits of Period B may have been constructed and used sequentially. This open settlement was probably replaced during the mid first millennium bc, possibly without a break, by a palisaded enclosure (Period C), which may have contained a ring-groove house and a four-post structure. Continued domestic activity (Period D) was suggested by a single pit outside the enclosure, dated to the late first millennium bc/early first millennium ad. The limited evidence of the economy of the settlements suggests a mixed farming system.

Perempuan Difabel Berhadapan Hukum

MUWAZAH ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 183
Author(s):  
Muhammad Julijanto
Keyword(s):  
Sexual Violence ◽  
Police Department ◽  
Limited Evidence ◽  
Legal Process ◽  
Women With Disabilities ◽  
Legal Cases ◽  
Limited Access ◽  
Lack Of Information ◽  
The Disabled ◽  
Examination Room

This paper describes women with disabilities who are facing legal cases, most of which are related to cases of sexual violence. The handling of cases of women with disabilities experienced problems, namely: law enforcers did not have a maximum understanding of the disabled; 2) limited access; 3) limited evidence: 4) difficulty communicating; 5) the community does not want to be a witness; 6) length of legal process; 7) lack of knowledge about the law; 8) there is no assistance in the police department during inspections, the examination room is not easily accessible, and the lack of information for victims; 9) the prosecutor does not provide information if the file has been delegated and; 10) judges have difficulty communicating. Therefore, law enforcers must have the same perception of diffables, so that they get legal justice.

scholarly journals Personality dynamics at work: The effects of form, time, and context of variability

2021 ◽  
pp. 089020702110173
Author(s):  
Nadin Beckmann ◽  
Damian P Birney ◽  
Amirali Minbashian ◽  
Jens F Beckmann
Keyword(s):  
Individual Differences ◽  
Cognitive Ability ◽  
Temporal Stability ◽  
Limited Evidence ◽  
Short Term ◽  
State Data ◽  
The Status ◽  
Over Time ◽  
Trait Variability

The study aimed to investigate the status of within-person state variability in neuroticism and conscientiousness as individual differences constructs by exploring their (a) temporal stability, (b) cross-context consistency, (c) empirical links to selected antecedents, and (d) empirical links to longer term trait variability. Employing a sample of professionals ( N = 346) from Australian organisations, personality state data together with situation appraisals were collected using experience sampling methodology in field and repeatedly in lab-like settings. Data on personality traits, cognitive ability, and motivational mindsets were collected at baseline and after two years. Contingent (situation contingencies) and non-contingent (relative SD) state variability indices were relatively stable over time and across contexts. Only a small number of predictive effects of state variability were observed, and these differed across contexts. Cognitive ability appeared to be associated with state variability under lab-like conditions. There was limited evidence of links between short-term state and long-term trait variability, except for a small effect for neuroticism. Some evidence of positive manifold was found for non-contingent variability. Systematic efforts are required to further elucidate the complex pattern of results regarding the antecedents, correlates and outcomes of individual differences in state variability.

scholarly journals Non-random associations in group housed rats (Rattus norvegicus)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Leanne Proops ◽  
Camille A. Troisi ◽  
Tanja K. Kleinhappel ◽  
Teresa Romero
Keyword(s):  
Network Analysis ◽  
Empirical Evidence ◽  
Rattus Norvegicus ◽  
Dominance Hierarchy ◽  
Group Living ◽  
Ecological Factors ◽  
Limited Evidence ◽  
Rat Strains ◽  
Social Species ◽  
Over Time

AbstractEcological factors, such as predation, have traditionally been used to explain sociability. However, it is increasingly recognised that individuals within a group do not associate randomly, and that these non-random associations can generate fitness advantages. The majority of the empirical evidence on differentiated associations in group-living mammals, however, comes from a limited number of taxa and we still know very little about their occurrence and characteristics in some highly social species, such as rats (Rattus spp.). Here, using network analysis, we quantified association patterns in four groups of male fancy rats. We found that the associations between rats were not randomly distributed and that most individuals had significantly more preferred/avoided associates than expected by random. We also found that these preferences can be stable over time, and that they were not influenced by individuals’ rank position in the dominance hierarchy. Our findings are consistent with work in other mammals, but contrast with the limited evidence available for other rat strains. While further studies in groups with different demographic composition are warranted to confirm our findings, the occurrence of differentiated associations in all male groups of rats have important implications for the management and welfare of captive rat populations.

scholarly journals Clinical Features And Outcomes Of Streptococcus Anginosus Group Infective Endocarditis: A Multicenter Matched Cohort Study

2021 ◽  
Author(s):  
Francesc Escrihuela-Vidal ◽  
Luis Eduardo López-Cortés ◽  
Laura Escolà-Vergé ◽  
Arístides De Alarcón González ◽  
Guillermo Cuervo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Septic Shock ◽  
Severe Disease ◽  
Indications For Surgery ◽  
Matched Cohort ◽  
Limited Evidence ◽  
Native Valve ◽  
Streptococcus Anginosus ◽  
Streptococcus Gallolyticus ◽  
Viridans Group Streptococci

Abstract Background Although Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption. Methods We performed a retrospective analysis of prospectively collected data from consecutive patients with definite SAG endocarditis in 28 centers in Spain and Italy. A comparison between cases due to SAG endocarditis and viridans group streptococci (VGS) or Streptococcus gallolyticus group (SGG) was performed in a 1:2 matched analysis. Results Of 5,336 consecutive cases of definite endocarditis, 72 (1.4%) were due to SAG and matched with 144 cases due to VGS/SGG. SAG endocarditis was community acquired in 64 (88.9%) cases and affected aortic native valve in 29 (40.3%). When comparing SAG and VGS/SGG endocarditis, no significant differences were found in septic shock (8.3% vs. 3.5%, P = 0.116); valve disorder, including perforation (22.2% vs. 18.1%, P = 0.584), pseudoaneurysm (16.7% vs. 8.3%, P = 0.108), or prosthesis dehiscence (1.4% vs. 6.3%, P = 0.170); paravalvular complications, including abscess (25% vs. 18.8%, P = 0.264) and intracardiac fistula (5.6% vs. 3.5%, P = 0.485); heart failure (34.7% vs. 38.9%, P = 0.655); and embolic events (41.7% vs. 32.6%, P = 0.248). Indications for surgery (70.8% vs. 70.8%; P =1) and mortality (13.9% vs. 16.7%; P = 0.741) were similar between groups. Conclusions SAG endocarditis is an infrequent but serious condition that presents a prognosis similar to that of VGS/SGG

scholarly journals Quality of life in primary sclerosing cholangitis: a systematic review

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Elena Marcus ◽  
Paddy Stone ◽  
Anna-Maria Krooupa ◽  
Douglas Thorburn ◽  
Bella Vivat
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Clinical Research ◽  
Disease Progression ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Small Sample ◽  
Limited Evidence ◽  
Research Studies

Abstract Background Primary sclerosing cholangitis (PSC) is a rare bile duct and liver disease which can considerably impact quality of life (QoL). As part of a project developing a measure of QoL for people with PSC, we conducted a systematic review with four review questions. The first of these questions overlaps with a recently published systematic review, so this paper reports on the last three of our initial four questions: (A) How does QoL in PSC compare with other groups?, (B) Which attributes/factors are associated with impaired QoL in PSC?, (C) Which interventions are effective in improving QoL in people with PSC?. Methods We systematically searched five databases from inception to 1 November 2020 and assessed the methodological quality of included studies using standard checklists. Results We identified 28 studies: 17 for (A), ten for (B), and nine for (C). Limited evidence was found for all review questions, with few studies included in each comparison, and small sample sizes. The limited evidence available indicated poorer QoL for people with PSC compared with healthy controls, but findings were mixed for comparisons with the general population. QoL outcomes in PSC were comparable to other chronic conditions. Itch, pain, jaundice, severity of inflammatory bowel disease, liver cirrhosis, and large-duct PSC were all associated with impaired QoL. No associations were found between QoL and PSC severity measured with surrogate markers of disease progression or one of three prognostic scoring systems. No interventions were found to improve QoL outcomes. Conclusion The limited findings from included studies suggest that markers of disease progression used in clinical trials may not reflect the experiences of people with PSC. This highlights the importance for clinical research studies to assess QoL alongside clinical and laboratory-based outcomes. A valid and responsive PSC-specific measure of QoL, to adequately capture all issues of importance to people with PSC, would therefore be helpful for clinical research studies.

How we treat sickle hepatopathy and liver transplantation in adults

Blood ◽  
2014 ◽  
Vol 123 (15) ◽  
pp. 2302-2307 ◽  
Author(s):  
Kate Gardner ◽  
Abid Suddle ◽  
Pauline Kane ◽  
John O’Grady ◽  
Nigel Heaton ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Sickle Cell ◽  
Liver Dysfunction ◽  
Therapeutic Option ◽  
Organ Damage ◽  
Treatment Modalities ◽  
Cell Disease ◽  
Limited Evidence ◽  
Acute Form ◽  
Future Work

Abstract Sickle cell disease (SCD) has evolved into a debilitating disorder with emerging end-organ damage. One of the organs affected is the liver, causing “sickle hepatopathy,” an umbrella term for a variety of acute and chronic pathologies. Prevalence of liver dysfunction in SCD is unknown, with estimates of 10%. Dominant etiologies include gallstones, hepatic sequestration, viral hepatitis, and sickle cell intrahepatic cholestasis (SCIC). In addition, causes of liver disease outside SCD must be identified and managed. SCIC is an uncommon, severe subtype, with outcome of its acute form having vastly improved with exchange blood transfusion (EBT). In its chronic form, there is limited evidence for EBT programs as a therapeutic option. Liver transplantation may have a role in a subset of patients with minimal SCD-related other organ damage. In the transplantation setting, EBT is important to maintain a low hemoglobin S fraction peri- and posttransplantation. Liver dysfunction in SCD is likely to escalate as life span increases and patients incur incremental transfusional iron overload. Future work must concentrate on not only investigating the underlying pathogenesis, but also identifying in whom and when to intervene with the 2 treatment modalities available: EBT and liver transplantation.

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