Antibiotic-Laden Bone Cement Use and Revision Risk After Primary Total Knee Arthroplasty in U.S. Veterans

2020 ◽  
Vol 102 (22) ◽  
pp. 1939-1947
Author(s):  
Ilya Bendich ◽  
Ning Zhang ◽  
Jeffrey J. Barry ◽  
Derek T. Ward ◽  
Mary A. Whooley ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Bone Cement ◽  
Knee Arthroplasty ◽  
Primary Total Knee Arthroplasty ◽  
Total Knee ◽  
Revision Risk ◽  
Primary Total Knee

scholarly journals Cementing technique for total knee arthroplasty in cadavers using a pastry bone cement

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Hans Bösebeck ◽  
Anna-Maria Holl ◽  
Peter Ochsner ◽  
Manuel Groth ◽  
Kevin Stippich ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Bone Cement ◽  
Knee Arthroplasty ◽  
Primary Total Knee Arthroplasty ◽  
Pull Out ◽  
Ensure Patient Safety ◽  
Temperature Development ◽  
Total Knee ◽  
Primary Total Knee ◽  
Rule Out

Abstract Background In cemented primary total knee arthroplasty (TKA), aseptic loosening remains a major cause for failure. Cementing techniques and characteristics of a chosen cement play a key role for good fixation and implant survival. A pastry bone cement was developed to facilitate the cement preparation and to rule out most of preparation-associated application errors. The pastry bone cement was compared to a conventional polymethyl methacrylate cement in a TKA setting. Methods Standardized implantations of total knee endoprostheses were performed in bilateral knee cadavers to investigate handling properties, variables of cement application, working time, and temperature development. Mechanical aspects and cementation quality were assessed by pull-out trials and microscopic interface analysis. Results Both cements expressed similar characteristics during preparation and application, only the curing time of the pastry cement was about 3 min longer and the temperature peak was lower. Fractures of the conventional cement specimens differed from the pastry cement specimens in the tibial part, while no differences were found in the femoral part. Penetration depth of the pastry cement was similar (tibia) or deeper (femur) compared to the conventional cement. Conclusions The pastry cement facilitates the feasibility of cemented TKA. The pre-clinical tests indicate that the pastry bone cement fulfills the requirements for bone cement in the field of knee arthroplasty. A clinical trial is needed to further investigate the approach and ensure patient safety.

scholarly journals Antibiotic-Loaded Bone Cement in Prevention of Periprosthetic Joint Infections in Primary Total Knee Arthroplasty: A Register-based Multicentre Randomised Controlled Non-inferiority Trial (ALBA trial)

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e041096
Author(s):  
Tesfaye H Leta ◽  
Jan-Erik Gjertsen ◽  
Håvard Dale ◽  
Geir Hallan ◽  
Stein Håkon Låstad Lygre ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Bone Cement ◽  
Knee Arthroplasty ◽  
Primary Total Knee Arthroplasty ◽  
Current Evidence ◽  
Joint Infections ◽  
Total Knee ◽  
Randomised Controlled ◽  
Primary Total Knee

IntroductionThe current evidence on the efficacy of antibiotic-loaded bone cement (ALBC) in reducing the risk of periprosthetic joint infections (PJI) after primary joint reconstruction is insufficient. In several European countries, the use of ALBC is routine practice unlike in the USA where ALBC use is not approved in low-risk patients. Therefore, we designed a double-blinded pragmatic multicentre register-based randomised controlled non-inferiority trial to investigate the effects of ALBC compared with plain bone cement in primary total knee arthroplasty (TKA).Methods and analysisA minimum of 9,172 patients undergoing full-cemented primary TKA will be recruited and equally randomised into the ALBC group and the plain bone cement group. This trial will be conducted in Norwegian hospitals that routinely perform cemented primary TKA. The primary outcome will be risk of revision surgery due to PJI at 1-year of follow-up. Secondary outcomes will be: risk of revision due to any reason including aseptic loosening at 1, 6, 10 and 20 years of follow-up; patient-related outcome measures like function, pain, satisfaction and health-related quality of life at 1, 6 and 10 years of follow-up; risk of changes in the microbial pattern and resistance profiles of organisms cultured in subsequent revisions at 1, 6, 10 and 20 years of follow-up; cost-effectiveness of routine ALBC versus plain bone cement use in primary TKA. We will use 1:1 randomisation with random permuted blocks and stratify by participating hospitals to randomise patients to receive ALBC or plain bone cement. Inclusion, randomisation and follow-up will be through the Norwegian Arthroplasty Register.Ethics and disseminationThe trial was approved by the Western Norway Regional Committees on Medical and Health Research Ethics (reference number: 2019/751/REK vest) on 21 June 2019. The findings of this trial will be disseminated through peer-reviewed publications and conference presentations.Trial registration numberNCT04135170.

Antibiotic Bone Cement Cannot Reduce Deep Infection After Primary Total Knee Arthroplasty

Orthopedics ◽  
2015 ◽  
Vol 38 (6) ◽  
pp. e462-e466 ◽  
Author(s):  
Hai Wang ◽  
Gui-Xing Qiu ◽  
Jin Lin ◽  
Jin Jin ◽  
Wen-Wei Qian ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Bone Cement ◽  
Knee Arthroplasty ◽  
Primary Total Knee Arthroplasty ◽  
Deep Infection ◽  
Total Knee ◽  
Primary Total Knee

Antibiotic-loaded bone cement reduces risk of infections in primary total knee arthroplasty? A systematic review

2016 ◽  
Vol 24 (10) ◽  
pp. 3168-3174 ◽  
Author(s):  
A. Schiavone Panni ◽  
K. Corona ◽  
M. Giulianelli ◽  
G. Mazzitelli ◽  
C. Del Regno ◽  
...  
Keyword(s):  
Systematic Review ◽  
Total Knee Arthroplasty ◽  
Bone Cement ◽  
Knee Arthroplasty ◽  
Primary Total Knee Arthroplasty ◽  
Total Knee ◽  
Primary Total Knee

Evaluation of surgical technique of screws and bone cement in R and C tibial bone defects correction of primary Total Knee Arthroplasty

2021 ◽  
pp. 1-6
Author(s):  
Shouye Hu ◽  
Chao Lu ◽  
Zhi Yang ◽  
Kan Peng
Keyword(s):  
Total Knee Arthroplasty ◽  
Surgical Technique ◽  
Bone Cement ◽  
Knee Arthroplasty ◽  
Primary Total Knee Arthroplasty ◽  
Bone Defects ◽  
Tibial Bone ◽  
Total Knee ◽  
Primary Total Knee

Objective: The use of screws and cement is a well–known technique for repairing proximal tibial bone defects during primary total knee arthroplasty (TKA). The purpose of this study was to summarize our experience of using of screws and cement for R and C tibial bone defects in primary TKA.

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