The Optimal Dosing Regimen for Tranexamic Acid in Revision Total Hip Arthroplasty

2020 ◽  
Vol 102 (21) ◽  
pp. 1883-1890
Author(s):  
Robert A. Sershon ◽  
Yale A. Fillingham ◽  
Matthew P. Abdel ◽  
Arthur L. Malkani ◽  
Ran Schwarzkopf ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Revision Total Hip Arthroplasty ◽  
Dosing Regimen ◽  
Total Hip ◽  
Optimal Dosing

scholarly journals Use of Topical Tranexamic Acid Reduces Direct and Indirect Blood Loss and Transfusion Rates in Revision Total Hip Arthroplasty

2019 ◽  
Vol 16 (S2) ◽  
pp. 285-292
Author(s):  
Elina Huerfano ◽  
Manuel Huerfano ◽  
Kate Shanaghan ◽  
Maureen Barlow ◽  
Stavros Memtsoudis ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Revision Total Hip Arthroplasty ◽  
Total Hip ◽  
Topical Tranexamic Acid

Tranexamic Acid Reduces Blood Transfusions in Revision Total Hip Arthroplasty

2016 ◽  
Vol 31 (12) ◽  
pp. 2850-2855.e1 ◽  
Author(s):  
Kwan J. Park ◽  
Cory G. Couch ◽  
Paul K. Edwards ◽  
Eric R. Siegel ◽  
Simon C. Mears ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Blood Transfusions ◽  
Revision Total Hip Arthroplasty ◽  
Total Hip

Intravenous tranexamic acid reduces blood transfusions in revision total hip arthroplasty: a meta-analysis

2019 ◽  
Vol 8 (11) ◽  
pp. 917-928
Author(s):  
Wen-qiang Xin ◽  
Ya-long Gao ◽  
Jun Shen ◽  
Xin-yu Yang
Keyword(s):  
Venous Thromboembolism ◽  
Total Hip Arthroplasty ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Revision Total Hip Arthroplasty ◽  
Weighted Mean ◽  
Total Hip ◽  
Operation Duration

Aim: We performed a meta-analysis to systematically assess the efficacy and safety of intravenous tranexamic acid in revision total hip arthroplasty. Method: Potential academic articles were identified from Cochrane Library, Medline, PubMed, EMBASE, ScienceDirect and other databases. The time range we retrieved from was that from the inception of electronic databases to February 2019. Gray studies were identified from the references of included literature reports. STATA version 11.0 was used to analyze the pooled data. Results: A total of eight articles were involved in our study. The overall participants of tranexamic acid (TXA) group were 3533, whereas it was 11,007 in the control group. Our meta-analysis showed that TXA is preferable for revision total hip arthroplasty because of its lower value of hemoglobin reduction (weighted mean difference = -1.277–1.405; 95% CI: -1.996 to -0.559; p < 0.001), the rate of blood transfusion (odds ratio: 0.233; 95% CI: 0.129–0.422; p < 0.001) and the number of red blood cell units transfused (weighted mean difference = -0.978; 95% CI = -1.631 to -0.324; p = 0.003). However, there was no difference in calculated blood loss (p = 0.075), operation duration (p = 0.569) and venous thromboembolism complications (p = 0.338). Conclusion: Based on available evidence, use of intravenous TXA for patients undergoing revision arthroplasty may reduce hemoglobin reduction, number of red blood cell units transfused and blood transfusion rate without increasing the risk of venous thromboembolism and length of operation duration. Given the relevant possible biases in our study, adequately powered and better-designed studies with long-term follow-up are required to reach a firmer conclusion.

Clinical, functional and radiographic outcomes after revision total hip arthroplasty with tapered fluted modular or non-modular stems: a systematic review

2021 ◽  
pp. 112070002110043
Author(s):  
Antonios A Koutalos ◽  
Sokratis Varitimidis ◽  
Konstantinos N Malizos ◽  
Theofilos Karachalios
Keyword(s):  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Revision Rate ◽  
Clinical Results ◽  
Fracture Rate ◽  
Revision Total Hip Arthroplasty ◽  
Term Survival ◽  
Total Hip ◽  
Radiographic Outcomes

Purpose: The aim of the study was to systematically evaluate clinical outcomes of tapered fluted stems, either monoblock or modular, in revision total hip arthroplasty. Methods: PubMed, EMBASE and Web of Science and Cochrane databases were systematically searched by 2 researchers. Clinical studies reporting primarily on survival and re-revision rates, and secondarily on subsidence, dislocation, intraoperative fractures, periprosthetic fractures and infection were included. 2 investigators assessed the quality of the studies. Results: 46 studies were included in this review, reporting on 4601 stem revisions. The pooled re-revision rate was 5.1% and long-term survival ranged from 75% to 98.5%. No differences were observed between monoblock and modular stems regarding re-revision rate, dislocation rate, periprosthetic fracture rate or infection rates. Monoblock stems exhibited more subsidence and modular stems displayed more intraoperative fractures. Conclusions: Satisfactory results can be obtained with the use of tapered fluted end-bearing stems. Monoblock stems offer the same clinical results as modular stems.

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