Experimental Validation of the Radiographic Union Score for Tibial Fractures (RUST) Using Micro-Computed Tomography Scanning and Biomechanical Testing in an in-Vivo Rat Model

2018 ◽  
Vol 100 (21) ◽  
pp. 1871-1878 ◽  
Author(s):  
Sandra Fiset ◽  
Charles Godbout ◽  
Meghan C. Crookshank ◽  
Radovan Zdero ◽  
Aaron Nauth ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Rat Model ◽  
Experimental Validation ◽  
Biomechanical Testing ◽  
Tibial Fractures ◽  
Micro Computed Tomography ◽  
Computed Tomography Scanning ◽  
Radiographic Union ◽  
Tomography Scanning

scholarly journals Beam hardening artifacts in micro-computed tomography scanning can be reduced by X-ray beam filtration and the resulting images can be used to accurately measure BMD

Bone ◽  
2009 ◽  
Vol 45 (6) ◽  
pp. 1104-1116 ◽  
Author(s):  
Jeffrey A. Meganck ◽  
Kenneth M. Kozloff ◽  
Michael M. Thornton ◽  
Stephen M. Broski ◽  
Steven A. Goldstein
Keyword(s):  
Computed Tomography ◽  
Micro Computed Tomography ◽  
Beam Hardening ◽  
X Ray ◽  
Computed Tomography Scanning ◽  
Tomography Scanning

scholarly journals The first mainland European Mesozoic click-beetle (Coleoptera: Elateridae) revealed by X-ray micro-computed tomography scanning of an Upper Cretaceous amber from Hungary

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Márton Szabó ◽  
Robin Kundrata ◽  
Johana Hoffmannova ◽  
Tamás Németh ◽  
Emese Bodor ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Upper Cretaceous ◽  
Micro Computed Tomography ◽  
Click Beetles ◽  
X Ray ◽  
The Past ◽  
Click Beetle ◽  
Computed Tomography Scanning ◽  
Source Of Information ◽  
Tomography Scanning

AbstractFossil bioinclusions in amber are invaluable source of information on the past evolution and diversity of various organisms, as well as on the paleoecosystems in general. The click-beetles, Elateridae, which originated and greatly diversified during the Mesozoic, are mostly known from the adpression-like fossils, and their diversity in the Cretaceous ambers is only poorly documented. In this study, we describe a new click-beetle based on an incomplete inclusion in ajkaite, an Upper Cretaceous (Santonian) amber from the Ajka Coal Formation from Hungary. We used X-ray micro-computed tomography scanning to reconstruct its morphology because it is deposited in an opaque piece of amber. Our results suggest that the newly described Ajkaelater merkli gen. et sp. nov. belongs to subfamily Elaterinae. It represents the first Mesozoic beetle reported from Hungary, and the first Mesozoic Elateridae formally described from mainland Europe. Our discovery supports an Eurasian distribution and diversification of Elaterinae already in the Cretaceous. The paleoenvironment of the Ajka Coal Formation agrees well with the presumed habitat preference of the new fossil taxon. The discovery of a presumably saproxylic click-beetle shed further light on the yet poorly known paleoecosystem of the Santonian present-day western Hungary.

scholarly journals Development of a micro-CT mouse holder for a femur defect mouse model

2020 ◽  
Author(s):  
Graeme R. Paul ◽  
Peter Schwilch ◽  
Esther Wehrle ◽  
Gisela A. Kuhn ◽  
Ralph Müller
Keyword(s):  
Computed Tomography ◽  
Mouse Model ◽  
Femur Fracture ◽  
Use Cases ◽  
Rigid Fixation ◽  
Micro Ct ◽  
Micro Computed Tomography ◽  
Defect Healing ◽  
Computed Tomography Scanning ◽  
Tomography Scanning

AbstractCorrect fixation of an object is essential for accurate micro computed tomography scanning. In this document, we provide a motivation for, description of, and use cases for a mouse holder appropriate for holding an externally fixated mouse in femur fracture/defect healing experiments. In addition to rigid fixation, the holder provides heating and anaesthetic gas to ensure correct anaesthetic conditions for the animal. We provide the description and design files for a Scanco viva40 scanner, but with small changes, the holder can be used with other scanners.

Three-dimensional model of an ancient Egyptian falcon mummy skeleton

2015 ◽  
Vol 21 (4) ◽  
pp. 368-372 ◽  
Author(s):  
Anton Du Plessis ◽  
Ruhan Slabbert ◽  
Liani Colette Swanepoel ◽  
Johan Els ◽  
Gerrie J Booysen ◽  
...  
Keyword(s):  
Computed Tomography ◽  
3D Printing ◽  
Three Dimensional ◽  
Micro Computed Tomography ◽  
Three Dimensional Model ◽  
Content Type ◽  
3D Print ◽  
Ancient Egyptian ◽  
Computed Tomography Scanning ◽  
Tomography Scanning

Purpose – The purpose of this paper is to present the first detailed three-dimensional (3D) print from micro-computed tomography data of the skeleton of an ancient Egyptian falcon mummy. Design/methodology/approach – Radiographic analysis of an ancient Egyptian falcon mummy housed at Iziko Museums of South Africa was performed using non-destructive x-ray micro-computed tomography. A 1:1 physical replica of its skeleton was printed in a polymer material (polyamide) using 3D printing technology. Findings – The combination of high-resolution computed tomography scanning and rapid prototyping allowed us to create an accurate 1:1 model of a biological object hidden by wrappings. This model can be used to study skeletal features and morphology and also enhance exhibitions hosted within the museum. Originality/value – This is the first replica of its kind made of an ancient Egyptian falcon mummy skeleton. The combination of computed tomography scanning and 3D printing has the potential to facilitate scientific research and stimulate public interest in Egyptology.

scholarly journals Bone Toolbox: Biomarkers, Imaging Tools, Biomechanics, and Histomorphometry

2018 ◽  
Vol 46 (5) ◽  
pp. 511-529 ◽  
Author(s):  
Aurore Varela ◽  
Jacquelin Jolette
Keyword(s):  
Computed Tomography ◽  
Bone Histomorphometry ◽  
Structural Changes ◽  
Imaging Techniques ◽  
Quantitative Computed Tomography ◽  
Biomechanical Testing ◽  
Drug Effects ◽  
Imaging Modalities ◽  
Micro Computed Tomography

Bone is a unique tissue with turnover, metabolic, and cellular activities that vary through development to aging and with a mineralized matrix in which the current state and the history of a bone coexist. Qualitative histopathology often lacks sensitivity to detect changes in bone formation, mineralization and resorption, which often requires chronic dosing to result in structural changes such as variation in bone mass and geometry. A large panel of modalities can be used to fully analyze the health of the skeleton, including biomarker evaluation in serum or urine, imaging techniques ranging from radiology to computed tomography, biomechanical testing, and undecalcified tissue processing with bone histomorphometry. The use of clinically relevant biomarkers provides an important noninvasive, sensitive, rapid, and real-time tool to monitor bone activity at the whole skeleton level when conducting safety assessments in a preclinical setting. Imaging modalities also allow in vivo longitudinal assessments with a powerful, noninvasive and clinically translatable tools to monitor drug effects. Different imaging modalities are used in the preclinical studies to evaluate the bone tissues: standard radiography, dual-energy X-ray absorptiometry, peripheral quantitative computed tomography (pQCT), micro-computed tomography, and high-resolution pQCT. Bone histomorphometry is an important tool that provides sensitive evaluation to detect effects of test articles on bone resorption, formation, mineralization, remodeling rates and growth to address a potential target- or class-related theoretical bone liability. Ultimately, the measurement of bone mechanical properties in pharmaceutical testing is critical to understand the potential effects of that pharmaceutical on bone health and fracture risk. Important considerations are required for including these different techniques in toxicology rodents and nonrodent studies, to actually integrate these into safety assessment.

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