Magnetic Resonance-Guided Focused Ultrasound Versus Conventional Radiation Therapy for Painful Bone Metastasis

2017 ◽  
Vol 99A (18) ◽  
pp. 1572-1578 ◽  
Author(s):  
Hsin-Lun Lee ◽  
Chia-Chun Kuo ◽  
Jo-Ting Tsai ◽  
Chun-You Chen ◽  
Meng-Huang Wu ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Magnetic Resonance ◽  
Bone Metastasis ◽  
Focused Ultrasound ◽  
Painful Bone Metastasis ◽  
Conventional Radiation ◽  
Conventional Radiation Therapy

Combining Low-Dose Radiation Therapy and Magnetic Resonance Guided Focused Ultrasound to Reduce Amyloid-β Deposition in Alzheimer’s Disease

2021 ◽  
pp. 1-4
Author(s):  
Paolo Farace ◽  
Stefano Tamburin
Keyword(s):  
Alzheimer’S Disease ◽  
Clinical Trials ◽  
Radiation Therapy ◽  
White Matter ◽  
Magnetic Resonance ◽  
Low Dose ◽  
Focused Ultrasound ◽  
Amyloid Β ◽  
Low Dose Radiation ◽  
Dose Radiation

Amyloid-β deposition is one of the neuropathological hallmarks of Alzheimer’s disease (AD), but pharmacological strategies toward its reduction are poorly effective. Preclinical studies indicate that low-dose radiation therapy (LD-RT) may reduce brain amyloid-β. Animal models and proof-of-concept preliminary data in humans have shown that magnetic resonance guided focused ultrasound (MRgFUS) can reversibly open the blood-brain-barrier and facilitate the delivery of targeted therapeutics to the hippocampus, to reduce amyloid-β and promote neurogenesis in AD. Ongoing clinical trials on AD are exploring whole-brain LD-RT, which may damage radio-sensitive structures, i.e., hippocampus and white matter, thus contributing to reduced neurogenesis and radiation-induced cognitive decline. However, selective irradiation of cortical amyloid-β plaques through advanced LD-RT techniques might spare the hippocampus and white matter. We propose combined use of advanced LD-RT and targeted drug delivery through MRgFUS for future clinical trials to reduce amyloid-β deposition in AD since its preclinical stages.

Outcomes of Single Fraction Conventional Radiation Therapy for Palliation of Painful Vertebral Metastases

2019 ◽  
Vol 103 (5) ◽  
pp. E39-E40
Author(s):  
Sonal S. Noticewala ◽  
Daniel R. Gomez ◽  
Chad Tang ◽  
Laurence D. Rhines ◽  
Claudio E. Tatsui ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Vertebral Metastases ◽  
Single Fraction ◽  
Conventional Radiation ◽  
Conventional Radiation Therapy

scholarly journals Hypofractionated vs. conventional radiation therapy for stage III non-small cell lung cancer treated without chemotherapy

2019 ◽  
Vol 59 (2) ◽  
pp. 164-170
Author(s):  
Michelle Iocolano ◽  
Aaron T. Wild ◽  
Margaret Hannum ◽  
Zhigang Zhang ◽  
Charles B. Simone ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Stage Iii ◽  
Small Cell Lung ◽  
Conventional Radiation ◽  
Conventional Radiation Therapy
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