Perivascular Stem Cells Diminish Muscle Atrophy Following Massive Rotator Cuff Tears in a Small Animal Model

2017 ◽  
Vol 99 (4) ◽  
pp. 331-341 ◽  
Author(s):  
Claire D. Eliasberg ◽  
Ayelet Dar ◽  
Andrew R. Jensen ◽  
Iain R. Murray ◽  
Winters R. Hardy ◽  
...  
Keyword(s):  
Stem Cells ◽  
Animal Model ◽  
Rotator Cuff ◽  
Muscle Atrophy ◽  
Small Animal ◽  
Rotator Cuff Tears ◽  
Small Animal Model ◽  
Massive Rotator Cuff Tears ◽  
Perivascular Stem Cells

The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats

2019 ◽  
Vol 28 (4) ◽  
pp. 654-664 ◽  
Author(s):  
Benjamin B. Rothrauff ◽  
Catherine A. Smith ◽  
Gerald A. Ferrer ◽  
João V. Novaretti ◽  
Thierry Pauyo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Rotator Cuff ◽  
Rotator Cuff Tears ◽  
Adipose Derived Stem Cells ◽  
Massive Rotator Cuff Tears

Establishing a Mouse Model to Evaluate Mesenchymal Stem Cells as a Potential Preoperative Adjuvant in the Management of Massive Rotator Cuff Tears

2015 ◽  
Vol 24 (8) ◽  
pp. e244-e245
Author(s):  
Adam Z. Khan ◽  
Tomasz J. Kowalski ◽  
Cameron A. Garagozlo ◽  
Claire D. Eliasberg ◽  
Owen J. McBride ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Rotator Cuff ◽  
Mouse Model ◽  
Rotator Cuff Tears ◽  
Massive Rotator Cuff Tears

scholarly journals Primary versus revision arthroscopic bridging reconstruction using dermal allograft: a clinical and radiographic analysis (243)

2021 ◽  
Vol 9 (10_suppl5) ◽  
pp. 2325967121S0035
Author(s):  
Ivan Wong ◽  
Sara Sparavalo ◽  
Jie Ma ◽  
Nedal Alkhatib
Keyword(s):  
Rotator Cuff ◽  
Muscle Atrophy ◽  
Fatty Infiltration ◽  
Rotator Cuff Tears ◽  
Primary Group ◽  
Dash Score ◽  
Massive Rotator Cuff Tears ◽  
Western Ontario Rotator Cuff ◽  
Goutallier Classification

Objectives: Large or massive rotator cuff tears make up between 10-40% of all rotator cuff tears, yet there is no agreement on the best treatment. Previous studies have shown that acellular human dermal allograft (AHDA) can be used for bridging reconstruction with positive patient outcomes. The use of this surgical technique has not been extensively studied in the primary or revision surgical setting. The main objective of this study was to compare the clinical and radiographic outcomes of patients who received primary or revision arthroscopic bridging reconstruction. Methods: This study is a retrospective review of a sequential series of patients who underwent arthroscopic bridging reconstruction (ABR) using AHDA by the primary author (IW). A total of 130 patients underwent ABR between 2010 and 2018. The inclusion criteria were patients with completed Western Ontario Rotator Cuff (WORC) questionnaire, Disabilities of the Arm, Shoulder, and Hand (DASH) score, or both pre-operatively and at multiple post-operative timepoints. Patients with missing WORC scores were excluded from the study. Eighty-three patients were included following chart review. Patients with available post-operative MRIs were also used for radiological assessment by an independent MSK-trained radiologist. Post-operative MRIs were reviewed to assess for graft integrity and changes to rotator cuff muscle atrophy (using the Warner classification) and fatty degeneration (using the Goutallier classification). Results: There were 46 patients who received primary ABR and 37 who received revision ABR. Forty-eight patients had a post-operative MRI available for review (Primary: 25; Revision: 23). The demographics are summarized in Table 1. Both groups showed a significant improvement in WORC score post-operatively (p<0.001). Primary ABR resulted in higher post-operative WORC scores as compared to revision ABR (p=0.015; Figure 1). The incidence of complete re-tears in the primary group was 8% and 17.4% in the revision group. More than 35% of patients in the primary group showed improvement in fatty infiltration of the infraspinatus and supraspinatus muscles. There was a higher progression in muscle atrophy in the revision group as compared to the primary group (74% and 30%, respectively). Conclusions: Arthroscopic primary arthroscopic bridging reconstruction for large/massive rotator cuff tears using acellular human dermal allograft had better improvement in their WORC scores compared to revision group at the final follow-up. Although the revision group had improved at the two-year follow-up, these changes in WORC score were not sustained at the final follow-up while the improvements were maintained for the primary group. The primary group had a smaller re-tear rate, better fatty infiltration and muscle atrophy as compared to the revision group. This suggests that primary bridging reconstruction provides better outcomes than a revision surgery.

scholarly journals Perivascular Stem Cells Diminish Muscle Atrophy and Retain Viability in a Rotator Cuff Tear Model

2016 ◽  
Vol 4 (7_suppl4) ◽  
pp. 2325967116S0014
Author(s):  
Claire Eliasberg ◽  
Andrew Jensen ◽  
Ayelet Dar ◽  
Tomasz J. Kowalski ◽  
Iain Murray ◽  
...  
Keyword(s):  
Stem Cells ◽  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Muscle Atrophy ◽  
Cuff Tear ◽  
Perivascular Stem Cells

Mesenchymal Stem Cells Seeded on Cross-Linked and Noncross-Linked Acellular Porcine Dermal Scaffolds for Long-Term Full-Thickness Hernia Repair in a Small Animal Model

2013 ◽  
Vol 38 (7) ◽  
pp. 572-579 ◽  
Author(s):  
Ondrej Mestak ◽  
Eva Matouskova ◽  
Zuzana Spurkova ◽  
Kamila Benkova ◽  
Pavel Vesely ◽  
...  
Keyword(s):  
Stem Cells ◽  
Animal Model ◽  
Mesenchymal Stem Cells ◽  
Hernia Repair ◽  
Small Animal ◽  
Full Thickness ◽  
Small Animal Model
Sign in / Sign up

Export Citation Format

Share Document