scholarly journals Effect of Long-Term Antiorthostatic Suspension in a Murine Model of Acute Lung Injury

2016 ◽  
Vol 9 (4) ◽  
pp. 332-338
Author(s):  
Tae Young Jang ◽  
Ah-Yeoun Jung ◽  
Young Hyo Kim
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Murine Model

Cannabidiol produces a long-term anti-inflammatory effect in a murine model of acute lung injury

2011 ◽  
Vol 25 ◽  
pp. S210 ◽  
Author(s):  
A. Ribeiro ◽  
V. Ferraz-de-Paula ◽  
M.L. Pinheiro ◽  
W.M. Quinteiro-Filho ◽  
A.T. Akamine ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Murine Model ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Metabolomics Investigation Reveals Metabolite Mediators Associated with Acute Lung Injury and Repair in a Murine Model of Influenza Pneumonia

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Liang Cui ◽  
Dahai Zheng ◽  
Yie Hou Lee ◽  
Tze Khee Chan ◽  
Yadunanda Kumar ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Murine Model ◽  
Influenza Pneumonia ◽  
Injury And Repair

scholarly journals Analysis of Risk Factors Associated with Outcomes in Road Traffic Injury Patients with Acute Lung Injury

2009 ◽  
Vol 37 (3) ◽  
pp. 835-840
Author(s):  
L Sheng ◽  
J-S Wu ◽  
M Zhang ◽  
S-W Xu ◽  
J-X Gan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Road Traffic ◽  
Road Traffic Injury ◽  
Apache Ii Score ◽  
Factors Associated ◽  
Traffic Injury ◽  
Short And Long Term

Over 50% of road traffic injury (RTI) patients experience post-traumatic acute lung injury (ALI) and it is, therefore, extremely important to identify the risk factors related to the poor outcomes associated with ALI in RTI populations. This study evaluated 19 potential risk factors associated with the outcomes of ALI in 366 RTI patients. They were divided into two groups: a ‘favourable outcomes group’ and an ‘unfavourable outcomes group’. The results indicated that the Acute Physiology and Chronic Health Evaluation II (APACHE II) score and the presence of gastrointestinal haemorrhage may help predict the outcomes of ALI in the early post-trauma phase of treatment. The duration of trauma and sepsis were shown to impact strongly on both the short- and long-term outcomes of ALI. Age (≥ 65 years) and disseminated intravascular coagulation in the early RTI phase were also independent risk factors for a poorer short- and long-term outcome in ALI.

scholarly journals Lung arginase activity is increased in ovine model of acute lung injury and contributes to long term pulmonary dysfunction

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Linda Sousse ◽  
Yusuke Yamamoto ◽  
Perenlei Enkhbaatar ◽  
Young‐Ming Yu ◽  
Sebastian Rehberg ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Arginase Activity ◽  
Pulmonary Dysfunction ◽  
Ovine Model

scholarly journals Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report

2012 ◽  
Vol 4 (1) ◽  
pp. e2012020 ◽  
Author(s):  
Puneet Chhabra ◽  
Arjun Dutt law ◽  
Dr vikas Suri ◽  
Dr pankaj Malhotra ◽  
Dr subhash Varma
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Rare Event ◽  
Primary Cns Lymphoma ◽  
Cns Lymphoma ◽  
High Dose ◽  
Connective Tissue Disorders ◽  
High Dose Regimen ◽  
Dose Methotrexate

Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate . Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate.

scholarly journals Vaping-induced lung injury: brief report for the practicing clinician

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Bashar Khiatah ◽  
Alex Murdoch ◽  
Charles Hubeny ◽  
Carl Constantine ◽  
Amanda Frugoli
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Case Vignette ◽  
Cigarette Use ◽  
Lung Injuries ◽  
Teenagers And Young Adults ◽  
The Usa ◽  
Physician Awareness ◽  
Harmful Effects

ABSTRACT The USA is witnessing an outbreak of vaping-induced lung injuries associated with the drastic rise in e-cigarette use, especially among teenagers and young adults. Our understanding of the harmful effects of these products is expanding as an increasing amount of consumers seek medical care for lung-related illnesses. The knowledge of the long-term sequelae of e-cigarette use is limited due to their novelty, but a growing association exists between use and acute lung injury. We describe a case vignette of vaping-induced lung injury to increase physician awareness and discuss the applicability of preliminary diagnostic criteria.

Acute lung injury leads to depression-like symptoms through upregulation of neutrophilic and neuronal NADPH oxidase signaling in a murine model

2017 ◽  
Vol 47 ◽  
pp. 218-226 ◽  
Author(s):  
Ahmed Nadeem ◽  
Nahid Siddiqui ◽  
Naif O. Al-Harbi ◽  
Sabry M. Attia ◽  
Shakir D. AlSharari ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Nadph Oxidase ◽  
Murine Model

scholarly journals Anti-inflammatory effects of triptolide by inhibiting the NF-κB signalling pathway in LPS-induced acute lung injury in a murine model

2014 ◽  
Vol 10 (1) ◽  
pp. 447-452 ◽  
Author(s):  
XIAN WANG ◽  
LEI ZHANG ◽  
WEI DUAN ◽  
BIN LIU ◽  
PING GONG ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Murine Model ◽  
Signalling Pathway ◽  
Anti Inflammatory

scholarly journals Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
James G. Macfarlane ◽  
David A. Dorward ◽  
Marie-Hélène Ruchaud-Sparagano ◽  
Jonathan Scott ◽  
Christopher D. Lucas ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Murine Model ◽  
Acute Inflammation ◽  
Neutrophil Function ◽  
Mouse Lung ◽  
Human Neutrophils ◽  
Bacterial Clearance ◽  
E Coli

Abstract Background Neutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when acute inflammation proceeds unchecked. A number of key neutrophil functions, including adhesion-dependent degranulation, are controlled by src family kinases. Dasatinib is a potent src inhibitor used in treating patients with chronic myeloid leukaemia and treatment-resistant acute lymphoblastic leukaemia. We hypothesized that dasatinib would attenuate acute inflammation by inhibiting neutrophil recruitment, degranulation and endothelial cell injury, without impairing bacterial clearance, in a murine model of bacteria-induced acute lung injury. C57BL/6 mice received intratracheal Escherichia coli, and were treated with intraperitoneal dasatinib or control. Bacterial clearance, lung injury, and markers of neutrophil recruitment and degranulation were measured. Separately, human blood neutrophils were exposed to dasatinib or control, and the effects on a range of neutrophil functions assessed. Results Dasatinib was associated with a dose-dependent significant increase in E. coli in the mouse lung, accompanied by impairment of organ function, reflected in significantly increased protein leak across the alveolar-capillary membrane. However, the number of neutrophils entering the lung was unaffected, suggesting that dasatinib impairs neutrophil function independent of migration. Dasatinib did not cause direct toxicity to human neutrophils, but led to significant reductions in phagocytosis of E. coli, adhesion, chemotaxis, generation of superoxide anion and degranulation of primary and secondary granules. However, no biologically important effect of dasatinib on neutrophil degranulation was observed in mice. Conclusions Contrary to our starting hypothesis, src kinase inhibition with dasatinib had a detrimental effect on bacterial clearance in the mouse lung and therefore does not represent an attractive therapeutic strategy to treat primary infective lung inflammation. Data from human neutrophils suggest that dasatanib has inhibitory effects on a range of neutrophil functions.

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