scholarly journals The volume of low-dose thoracic irradiation influences systemic inflammation-immunity status after chemoradiation in esophageal cancer

2021 ◽  
Vol 0 ◽  
pp. 0-0
Author(s):  
Yu-Chieh Ho ◽  
Yuan-Chun Lai ◽  
Hsuan-Yu Lin ◽  
Ming-Hui Ko ◽  
Sheng-Hung Wang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Systemic Inflammation ◽  
Low Dose ◽  
Thoracic Irradiation

scholarly journals PSIV-11 Effects of very low-dose antibiotics on gene expression profiles in ileal mucosa of weaned pigs infected with a pathogenic E. coli

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 286-286
Author(s):  
Kwangwook Kim ◽  
Sungbong Jang ◽  
Yanhong Liu
Keyword(s):  
Gene Expression ◽  
Systemic Inflammation ◽  
Low Dose ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Post Inoculation ◽  
Growth Promoter ◽  
Weaned Pigs ◽  
Ileal Mucosa ◽  
E Coli

Abstract Our previous studies have shown that supplementation of low-dose antibiotic growth promoter (AGP) exacerbated growth performance and systemic inflammation of weaned pigs infected with pathogenic Escherichia coli (E. coli). The objective of this experiment, which is extension of our previous report, was to investigate the effect of low-dose AGP on gene expression in ileal mucosa of weaned pigs experimentally infected with F18 E. coli. Thirty-four pigs (6.88 ± 1.03 kg BW) were individually housed in disease containment rooms and randomly allotted to one of three treatments (9 to 13 pigs/treatment). The three dietary treatments were control diet (control), and 2 additional diets supplemented with 0.5 or 50 mg/kg of AGP (carbadox), respectively. The experiment lasted 18 d [7 d before and 11 d after first inoculation (d 0)]. The F18 E. coli inoculum was orally provided to all pigs with the dose of 1010 cfu/3 mL for 3 consecutive days. Total RNA [4 to 6 pigs/treatment on d 5; 5 to 7 pigs/treatment on 11 post-inoculation (PI)] was extracted from ileal mucosa to analyze gene expression profiles by Batch-Tag-Seq. The modulated differential gene expression were defined by 1.5-fold difference and a cutoff of P < 0.05 using limma-voom package. All processed data were statistically analyzed and evaluated by PANTHER classification system to determine the biological process function of genes in these lists. Compared to control, supplementation of recommended-dose AGP down-regulated genes related to inflammatory responses on d 5 and 11 PI; whereas, feeding low-dose AGP up-regulated genes associated with negative regulation of metabolic process on d 5, but down-regulated the genes related to immune responses on d 11 PI. The present observations support adverse effects of low-dose AGP in our previous study, indicated by exacerbated the detrimental effects of E. coli infection on pigs’ growth rate, diarrhea and systemic inflammation.

Anti-inflammatory effects of low-dose radiotherapy in an experimental model of systemic inflammation in mice

2006 ◽  
Vol 66 (2) ◽  
pp. 560-567 ◽  
Author(s):  
Meritxell Arenas ◽  
Fèlix Gil ◽  
Meritxell Gironella ◽  
Víctor Hernández ◽  
Sandra Jorcano ◽  
...  
Keyword(s):  
Experimental Model ◽  
Systemic Inflammation ◽  
Low Dose ◽  
Low Dose Radiotherapy ◽  
Anti Inflammatory

scholarly journals Pre-operative Chemoradiation Therapy with 5-Fluorouracil and Low-dose Daily Cisplatin for Esophageal Cancer: A Preliminary Report

1999 ◽  
Vol 29 (3) ◽  
pp. 132-136 ◽  
Author(s):  
S. Shimoyama ◽  
T. Konishi ◽  
M. Kawahara ◽  
M. Kaminishi ◽  
A. Ito ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Preliminary Report ◽  
Low Dose ◽  
Chemoradiation Therapy

Low-Dose Versus High-Dose Radiation Therapy for the Palliation of Dysphagia From Esophageal Cancer: A Multicenter Retrospective Cohort Study

2020 ◽  
Vol 10 (4) ◽  
pp. e255-e263 ◽  
Author(s):  
Bram D. Vermeulen ◽  
Paul M. Jeene ◽  
Jasmijn Sijben ◽  
Robin Krol ◽  
Heidi Rütten ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Radiation Therapy ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Low Dose ◽  
High Dose ◽  
Dose Radiation

Daily low-dose cisplatin plus concurrent high-dose thoracic irradiation in locally advanced unresectable non-small-cell lung cancer: results of a phase II Southwest Oncology Group study.

1994 ◽  
Vol 12 (9) ◽  
pp. 1814-1820 ◽  
Author(s):  
M B Hazuka ◽  
J J Crowley ◽  
P A Bunn ◽  
M O'Rourke ◽  
T J Braun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Low Dose ◽  
Locally Advanced ◽  
Small Cell ◽  
Survival Duration ◽  
High Dose ◽  
Small Cell Lung ◽  
Stage Iiia ◽  
Thoracic Irradiation

PURPOSE This single-arm phase II trial was designed to evaluate the efficacy and toxicity of continuous-course, high-dose thoracic irradiation (RT) combined with concurrent daily low-dose cisplatin followed by high-dose cisplatin consolidation in patients with locally advanced unresectable non-small-cell lung cancer (NSCLC). The daily chemotherapy regimen was designed to optimize the radiosensitizing properties of cisplatin. PATIENTS AND METHODS Sixty-five patients from 21 participating institutions were entered onto the study between April 1989 and May 1991. Protocol therapy consisted of daily intravenous (i.v.) cisplatin (5 mg/m2) plus concurrent continuous-course RT (61 Gy over 6 1/2 weeks) both delivered Monday through Friday each week. After a 3- to 4-week rest period, this was followed by three 28-day cycles of cisplatin at 100 mg/m2 or subsequently 50 mg/m2 administered i.v. on days 1 and 8 of each cycle. RESULTS Sixty-four patients were eligible; the majority had unresectable stage IIIa (36%) or IIIb (55%) NSCLC. The remaining 9% had recurrent disease confined to the chest (five patients) or stage II disease (one patient). The feasibility of this regimen is demonstrated by the fact that only five patients (8%) were unable to complete daily cisplatin and RT because of toxicity. Esophagitis (16%), leukopenia (14%), nausea (8%), and vomiting (6%) were the most common severe (grade 3) toxicities. There was only one life-threatening toxicity (grade 4 nausea) and no treatment-related deaths. The objective response rate was 39%, and six patients (9%) achieved a radiographic complete response (CR). The median survival duration for all patients was 14 months, and the 1- and 2-year actuarial survival rates were 56% and 24%, respectively. For stage IIIa patients, the median survival duration and 2-year survival rate were 17 months and 38%, as compared with 10 months and 14% for stage IIIb patients, respectively. CONCLUSION Daily low-dose cisplatin plus concurrent high-dose continuous-course RT is a well-tolerated out-patient regimen. The survival results are encouraging and appear to be equivalent to more toxic combined approaches. These results warrant further testing of combined daily platinum analogs with RT.

Additive effect of concomitant multiple low-dose doxorubicin and thoracic irradiation on ex vivo cardiac performance of the rat heart

1998 ◽  
Vol 124 (3-4) ◽  
pp. 148-154 ◽  
Author(s):  
J. Wondergem ◽  
N. A. P. Franken ◽  
A. Chin ◽  
F. J. M. van Ravels ◽  
J. W. H. Leer
Keyword(s):  
Rat Heart ◽  
Low Dose ◽  
Ex Vivo ◽  
Cardiac Performance ◽  
Additive Effect ◽  
Thoracic Irradiation

scholarly journals Low-dose steroid alters in vivo endotoxin-induced systemic inflammation but does not influence autonomic dysfunction

2007 ◽  
Vol 13 (6) ◽  
pp. 358-368 ◽  
Author(s):  
Sonia M. Alvarez ◽  
Maria Katsamanis Karavidas ◽  
Susette M. Coyle ◽  
Shou-En Lu ◽  
Marie Macor ◽  
...  
Keyword(s):  
Autonomic Dysfunction ◽  
Systemic Inflammation ◽  
Low Dose

Preconception low dose aspirin treatment improves clinical pregnancy and live birth in women with higher systemic inflammation

2015 ◽  
Vol 104 (3) ◽  
pp. e349 ◽  
Author(s):  
L. Sjaarda ◽  
E. Mitchell ◽  
S.L. Mumford ◽  
R. Radin ◽  
N.J. Perkins ◽  
...  
Keyword(s):  
Live Birth ◽  
Systemic Inflammation ◽  
Low Dose ◽  
Clinical Pregnancy ◽  
Dose Aspirin ◽  
Low Dose Aspirin
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