scholarly journals The potential mechanism of Astragali Radix in the treatment of children with nephrotic syndrome

2021 ◽  
Vol 10 (9) ◽  
pp. 2298-2306
Author(s):  
Xiaomin Wen ◽  
Wenxiang Wang ◽  
Mei Zheng ◽  
Bei Song
Keyword(s):  
Nephrotic Syndrome ◽  
Potential Mechanism ◽  
Astragali Radix

scholarly journals tRNA-Derived Fragments in Podocytes with Adriamycin-Induced Injury Reveal the Potential Mechanism of Idiopathic Nephrotic Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Shanwen Li ◽  
Yiwen Liu ◽  
Xiaowei He ◽  
Xiagang Luo ◽  
Huimin Shi ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Signaling Pathway ◽  
Idiopathic Nephrotic Syndrome ◽  
Wnt Signaling Pathway ◽  
Differentially Expressed ◽  
Ras Signaling ◽  
Potential Mechanism ◽  
Significant Differential Expression ◽  
Podocyte Injury ◽  
Filtration Barrier

Idiopathic nephrotic syndrome (INS) is a disease involving injury to podocytes in the glomerular filtration barrier, and its specific causes have not been elucidated. Transfer RNA-derived fragments (tRFs), products of precise tRNA cleavage, have been indicated to play critical roles in various diseases. Currently, there is no relevant research on the role of tRFs in INS. This study intends to explore the changes in and importance of tRFs during podocyte injury in vitro and to further analyze the potential mechanism of INS. Differentially expressed tRFs in the adriamycin-treated group were identified by high-throughput sequencing and further verified by quantitative RT-PCR. In total, 203 tRFs with significant differential expression were identified, namely, 102 upregulated tRFs and 101 downregulated tRFs (q<0.05, ∣log2FC∣≥2). In particular, AS-tDR-008924, AS-tDR-011690, tDR-003634, AS-tDR-013354, tDR-011031, AS-tDR-001008, and AS-tDR-007319 were predicted to be involved in podocyte injury by targeting the Gpr, Wnt, Rac1, and other genes. Furthermore, gene ontology analysis showed that these differential tRFs were strongly associated with podocyte injury processes such as protein binding, cell adhesion, synapses, the actin cytoskeleton, and insulin-activate receptor activity. KEGG pathway analysis predicted that they participated in the PI3K-Akt signaling pathway, Wnt signaling pathway, and Ras signaling pathway. It was reported that these pathways contribute to podocyte injury. In conclusion, our study revealed that changes in the expression levels of tRFs might be involved in INS. Seven of the differentially expressed tRFs might play important roles in the process of podocyte injury and are worthy of further study.

scholarly journals Nephrin Redistribution on Podocytes Is a Potential Mechanism for Proteinuria in Patients with Primary Acquired Nephrotic Syndrome

2001 ◽  
Vol 158 (5) ◽  
pp. 1723-1731 ◽  
Author(s):  
Sophie Doublier ◽  
Vesa Ruotsalainen ◽  
Gennaro Salvidio ◽  
Enrico Lupia ◽  
Luigi Biancone ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Potential Mechanism

Uncovering the mechanism of Astragali Radix against nephrotic syndrome by intergrating lipidomics and network pharmacology

Phytomedicine ◽  
2020 ◽  
Vol 77 ◽  
pp. 153274
Author(s):  
Ai-Ping Li ◽  
Liu Yang ◽  
Ting Cui ◽  
Li-Chao Zhang ◽  
Yue-Tao Liu ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Network Pharmacology ◽  
Astragali Radix

scholarly journals Activation of the IL-2 Receptor in Podocytes: A Potential Mechanism for Podocyte Injury in Idiopathic Nephrotic Syndrome?

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0157907 ◽  
Author(s):  
Arnold H. Zea ◽  
Tyrus Stewart ◽  
Jeannine Ascani ◽  
David J. Tate ◽  
Beatriz Finkel-Jimenez ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Potential Mechanism ◽  
Podocyte Injury

Cytokine polymorphisms and nephrotic syndrome

2002 ◽  
Vol 102 (5) ◽  
pp. 513 ◽  
Author(s):  
PETER W. MATHIESON
Keyword(s):  
Nephrotic Syndrome
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