scholarly journals Evaluation of clinical outcomes of pancreatic cancer patients using circulating nucleic acids

2019 ◽  
Vol 4 ◽  
pp. 2-2
Author(s):  
Kunihiro Tsuchida
Keyword(s):  
Pancreatic Cancer ◽  
Nucleic Acids ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Circulating Nucleic Acids

scholarly journals P31-7 Clinical outcomes of cerebral infarction associated with Trousseau’s syndrome in advanced pancreatic cancer patients

2021 ◽  
Vol 32 ◽  
pp. S350
Author(s):  
Tomoyo Oguri ◽  
Hiroyuki Takeda ◽  
Kumiko Umemoto ◽  
Ayako Doi ◽  
Hiroyuki Arai ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cerebral Infarction ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Advanced Pancreatic Cancer ◽  
Trousseau’S Syndrome

scholarly journals Impact of KRAS Mutations on Clinical Outcomes in Pancreatic Cancer Patients Treated with First-line Gemcitabine-Based Chemotherapy

2011 ◽  
Vol 10 (10) ◽  
pp. 1993-1999 ◽  
Author(s):  
Seung Tae Kim ◽  
Do Hyoung Lim ◽  
Kee-Taek Jang ◽  
Taekyu Lim ◽  
Jeeyun Lee ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
First Line ◽  
Kras Mutations

Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine

2012 ◽  
Vol 13 (9) ◽  
pp. 1023-1035 ◽  
Author(s):  
Hye In Woo ◽  
Ka-Kyung Kim ◽  
Hangseok Choi ◽  
Seonwoo Kim ◽  
Kee-Taek Jang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Genetic Polymorphisms ◽  
Therapeutic Response

scholarly journals Clinical nutrition as part of the treatment pathway of pancreatic cancer patients: an expert consensus

2021 ◽  
Author(s):  
A. Carrato ◽  
L. Cerezo ◽  
J. Feliu ◽  
T. Macarulla ◽  
E. Martín-Pérez ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Health Care Professionals ◽  
Unmet Need ◽  
Screening Tools ◽  
Therapeutic Management ◽  
Care Process ◽  
Nutritional Screening

Abstract Purpose Malnutrition is a common problem among pancreatic cancer (PC) patients that negatively impacts on their quality of life (QoL) and clinical outcomes. The main objective of this consensus is to address the role of Medical Nutrition Therapy (MNT) into the comprehensive therapeutic management of PC patients. Methods A Spanish multidisciplinary group of specialists from the areas of Medical Oncology; Radiation Oncology; Endocrinology and Nutrition; and General Surgery agreed to assess the role of MNT as part of the best therapeutic management of PC patients. Results The panel established different recommendations focused on nutritional screening and nutritional screening tools, MNT strategies according to PC status, and MNT in palliative treatment. Conclusions There is an unmet need to integrate nutritional therapy as a crucial part of the multimodal care process in PC patients. Health authorities, health care professionals, cancer patients, and their families should be aware of the relevance of nutritional status and MNT on clinical outcomes and QoL of PC patients.

scholarly journals Genetic variability of the ABCC2 gene and clinical outcomes in pancreatic cancer patients

2019 ◽  
Vol 40 (4) ◽  
pp. 544-550 ◽  
Author(s):  
Manuel Gentiluomo ◽  
Paula Puchalt García ◽  
Alice Alessandra Galeotti ◽  
Renata Talar-Wojnarowska ◽  
Christine Tjaden ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Genetic Variability ◽  
Cancer Patients ◽  
Clinical Outcomes

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios at the time of chemoradiation to predict survival in resected pancreatic cancer patients.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 452-452
Author(s):  
Vanessa Xu ◽  
Enid Choi ◽  
Alexandra Hanlon ◽  
William Regine ◽  
Michael David Chuong
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Significant Relationship ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Cox Proportional Hazards ◽  
Borderline Resectable ◽  
Curative Intent ◽  
Lymphocyte Ratio

452 Background: Higher pre-treatment neutrophil-to-lymphocyte ratio (NLR) and lower platelet-to-lymphocyte ratio (PLR) are independent predictors for worse survival in cancer patients. The effect of chemoradiation (CRT) on NLR and PLR in pancreatic cancer patients who also undergo surgical resection has not been reported. Methods: A retrospective review was performed of pancreatic cancer patients treated at our institution with CRT either prior to or after surgery with curative intent. Overall survival was evaluated using Kaplan-Meier method. Univariate and multivariate Cox regression models were applied to evaluate the independent prognostic significance of NLR and PLR. Results: After excluding patients who did not have surgery, who received palliative radiation doses, or who had incomplete medical records, 81 out of 282 patients remained with median age 62 years (35-86). Of these, 24 (29.6%) were borderline resectable (BR) and received preoperative CRT while 57 (70.4%) received adjuvant CRT. Median total dose and number of fractions were 50.4 Gy (30-59.4) and 28 (5-33), respectively. Median pre-CRT and post-CRT NLR were 2.9 and 7.8, respectively. Median pre-CRT and post-CRT PLR were 211.3 and 457.5, respectively. Most patients had a decrease in NLR (85.2%) and PLR (72.8%) after CRT, with median changes of -4.95 for NLR and -178.33 for PLR. Cox proportional hazards analysis showed a trend towards significance for pre-CRT NLR (p=.08) regarding OS. A significant relationship was found between relapse free survival and both pre-CRT NLR (p=0.02) and PLR (p=0.01). The difference or percent change of neither NLR nor PLR was found to correlate with clinical outcomes. Conclusions: This is the first study to evaluate the effect of CRT on NLR and PLR in resected pancreas cancer patients. Similar to other reports, our data indicate that a significant relationship exists between NLR, PLR, and clinical outcomes. Identification of clinically meaningful NLR and PLR cut-off points for resected pancreatic cancer patients who also receive CRT is needed.

Abstract 2599: Circulating nucleic acids as biomarkers of prognosis and chemorefractory status in metastatic pancreatic cancer

2018 ◽  
Author(s):  
Vincent Bernard ◽  
Dong U. Kim ◽  
F. Anthony San Lucas ◽  
Jonathan Castillo ◽  
Kelvin Allenson ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Nucleic Acids ◽  
Metastatic Pancreatic Cancer ◽  
Circulating Nucleic Acids
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