scholarly journals Differential diagnosis of gastrointestinal stromal tumor by histopathology and immunohistochemistry

2018 ◽  
Vol 3 ◽  
pp. 27-27 ◽  
Author(s):  
Seiichi Hirota
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor

Gastrointestinal Stromal Tumor Presenting as a Recurrent Vaginal Mass

2004 ◽  
Vol 128 (12) ◽  
pp. 1442-1444 ◽  
Author(s):  
Katherine M. Ceballos ◽  
Julie-Ann Francis ◽  
John L. Mazurka
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Gastrointestinal Stromal Tumor ◽  
Interstitial Cell ◽  
Smooth Muscle Tumor ◽  
Stromal Tumor ◽  
Mesenchymal Neoplasms ◽  
Smooth Muscle Neoplasm ◽  
Rectal Involvement ◽  
Vaginal Smooth Muscle

Abstract Gastrointestinal stromal tumors are CD117 (c-Kit)–positive mesenchymal neoplasms with histologic and ultrastructural features of the interstitial cell of Cajal. While tumors outside of the gastrointestinal tract have been described, to our knowledge the case we present is the first such case in the vagina. We describe a 75-year-old woman with a recurrent vaginal gastrointestinal stromal tumor without apparent rectal involvement. This tumor was characterized by short intersecting fascicles of spindled cells, focal necrosis, and 12 to 15 mitoses per 50 high-power fields. Immunohistochemistry revealed diffuse cytoplasmic positivity for CD117 (c-Kit), CD34, vimentin, and h-caldesmon. Tumor cells were negative for S100, desmin, actin, and CAM 5.2. The differential diagnosis in this case included a vaginal smooth muscle tumor. While histologically similar to a smooth muscle neoplasm, the immunohistochemical profile ruled out smooth muscle differentiation. Gastrointestinal stromal tumor should be considered in the differential diagnosis of vaginal mesenchymal neoplasms.

scholarly journals Gastric schwannoma: a benign tumor often misdiagnosed as gastrointestinal stromal tumor

2015 ◽  
Vol 5 (3) ◽  
Author(s):  
Apurva S. Shah ◽  
Pravin M. Rathi ◽  
Vaibhav S. Somani ◽  
Astha M. Mulani
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Rare Case ◽  
Benign Tumor ◽  
Stromal Tumor ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Gastric Schwannoma ◽  
Gastric Mass

Gastric schwannomas are rare mesenchymal tumors that arise from the nerve plexus of gut wall. They present with nonspecific symptoms and are often detected incidentally. Preoperative investigation is not pathognomic and many are therefore misdiagnosed as gastrointestinal stromal tumors. We report a rare case of a 37-year old woman who underwent laparotomy for complex bilateral ovarian cyst with resection of gastric-gastrointestinal stromal tumor preoperatively, but confirmed to have a gastric schwannomas postoperatively. This case underscores the differential diagnosis of submucosal, exophytic gastric mass as schwannoma.

Morphological features useful in the differential diagnosis between undifferentiated carcinoma and gastrointestinal stromal tumor

2020 ◽  
Vol 46 ◽  
pp. 151527
Author(s):  
Bohuslava Vankova ◽  
Kristyna Behenska ◽  
Meret Bauer ◽  
Monika Sedivcova ◽  
Magdalena Daumova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Stromal Tumor ◽  
Undifferentiated Carcinoma ◽  
Morphological Features ◽  
Stromal Tumor

Gastrointestinal Stromal Tumor as Adnexal Tumor Differential Diagnosis: Two Cases

2011 ◽  
Vol 27 (2) ◽  
pp. 99-101
Author(s):  
Nuria-Laia Rodríguez-Mias ◽  
Santiago González-Núñez ◽  
Laura Garcia-De Miguel ◽  
Anna Bláquez-Ventura ◽  
Esther Valladares-Pérez ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Adnexal Tumor

scholarly journals Suture granuloma: a rare differential diagnosis of residual/recurrent gastrointestinal stromal tumor of stomach

2015 ◽  
Vol 5 (1) ◽  
pp. 5-8 ◽  
Author(s):  
Santosh Kumar Singh ◽  
Narayan Kannan ◽  
Rajnish Talwar ◽  
Arvind Kumar Tyagi ◽  
Renu Madan ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Rare Differential Diagnosis

scholarly journals Extra Gastrointestinal Stromal Tumor Pada Ovarium, Kasus Jarang

2020 ◽  
Vol 4 (2) ◽  
pp. 173-182
Author(s):  
Nana Liana ◽  
RZ Nizar ◽  
Aswiyanti Asri ◽  
Hera Novianti ◽  
Andi Friadi
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Stromal Tumor ◽  
Ovarian Tumor ◽  
Stromal Tumor ◽  
Ovarian Malignancy ◽  
Tumor Surgery ◽  
Pathological Anatomy ◽  
History Of ◽  
Gynecological Disorder ◽  
Rule Out

Objective : This article objective is to describe a woman with extra gastrointestinal stromal tumor (extra GIST) in ovary; Method : A case report and literature review; The author reports a woman 54 years old with complaints of swelling in the abdomen. Tumors suspected originate from ovary with an extension to abdominal wall. The patient had history of previous ovarian tumor surgery with pathological anatomy diagnosis was thecoma. Working diagnosis of the patient was residif ovarian malignancy and then suboptimal debulking was performed. Microscopically, ovarian tumors appear cellular and diffuse, partially arranged fascicles. Cells with rounded-spindle nuclei, mitosis ≥ 4 per 10 HPF. The conclusion was malignant thecoma which metastasizes to peritoneum and omentum. Differential diagnosis were GIST and leiomyosarcoma. Immunohistochemistry examination was performed with  Calretinin and CD117 to rule out the differential diagnosis. Calretinin were negative  and CD117 were strongly positively smeared. Based on the morphology and positive CD117 results, diagnosis was extra GIST of ovary.; Conclusion: Extra GIST in the ovary is an unusual location so that it can be misdiagnosed as a gynecological disorder. The differential diagnosis at this location is quite limited including thecoma, fibrothecoma and leiomyosarcoma.Keywords: extra gastrointestinal stromal tumor, ovary, thecoma

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