Long term outcomes of stereotactic conformal radiation therapy in the treatment of benign and low-grade brain tumors

2017 ◽  
Vol 6 (S9) ◽  
pp. S1489-S1490
Author(s):  
Jayant S. Goda ◽  
Tejpal Gupta ◽  
Rakesh Jalali
Keyword(s):  
Radiation Therapy ◽  
Brain Tumors ◽  
Low Grade ◽  
Long Term Outcomes ◽  
Conformal Radiation Therapy

Stereotactic conformal radiation therapy in the treatment of benign and low-grade brain tumors

2017 ◽  
Vol 6 (S7) ◽  
pp. S1200-S1204
Author(s):  
James D. Byrne ◽  
Trevor J. Royce ◽  
Jay S. Loeffler
Keyword(s):  
Radiation Therapy ◽  
Brain Tumors ◽  
Low Grade ◽  
Conformal Radiation Therapy

scholarly journals Growth Hormone Secretion After Conformal Radiation Therapy in Pediatric Patients With Localized Brain Tumors

2011 ◽  
Vol 29 (36) ◽  
pp. 4776-4780 ◽  
Author(s):  
Thomas E. Merchant ◽  
Susan R. Rose ◽  
Christina Bosley ◽  
Shengjie Wu ◽  
Xiaoping Xiong ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Radiation Therapy ◽  
Radiation Dose ◽  
Brain Tumors ◽  
Pediatric Patients ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Low Grade ◽  
Conformal Radiation Therapy ◽  
Gh Secretion

Purpose Growth hormone deficiency (GHD) after radiation therapy negatively affects growth and development and quality of life in children with brain tumors. Patients and Materials Between 1997 and 2008, 192 pediatric patients with localized primary brain tumors (ependymoma, n = 88; low-grade glioma, n = 51; craniopharyngioma, n = 28; high-grade glioma, n = 23; and other tumor types, n = 2) underwent provocative testing of GH secretion by using the secretogogues arginine and l-dopa before and after (6, 12, 36, and 60 months) conformal radiation therapy (CRT). A total of 664 arginine/l-dopa test procedures were performed. Results Baseline testing revealed preirradiation GHD in 22.9% of tested patients. On the basis of data from 118 patients, peak GH was modeled as an exponential function of time after CRT and mean radiation dose to the hypothalamus. The average patient was predicted to develop GHD with the following combinations of the time after CRT and mean dose to the hypothalamus: 12 months and more than 60 Gy; 36 months and 25 to 30 Gy; and 60 months and 15 to 20 Gy. A cumulative dose of 16.1 Gy to the hypothalamus would be considered the mean radiation dose required to achieve a 50% risk of GHD at 5 years (TD50/5). Conclusion GH secretion after CRT can be predicted on the basis of dose and time after irradiation in pediatric patients with localized brain tumors. These findings provide an objective radiation dose constraint for the hypothalamus.

Intensity-modulated radiation therapy versus 3D conformal radiation therapy for squamous cell carcinoma of the anal canal.

2013 ◽  
Vol 31 (4_suppl) ◽  
pp. 494-494 ◽  
Author(s):  
Michael Chuong ◽  
Jessica Freilich ◽  
Sarah Hoffe ◽  
William J. Fulp ◽  
Jill Weber ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Anal Cancer ◽  
Intensity Modulated Radiation Therapy ◽  
Long Term Outcomes ◽  
Conformal Radiation Therapy ◽  
Free Survival ◽  
Intensity Modulated ◽  
3D Conformal Radiation Therapy ◽  
Grade 3

494 Background: The emergence of intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer has dramatically lowered the incidence of severe toxicity while maintaining excellent long-term outcomes. We compared our institutional experience using 3D conformal radiation therapy (3DCRT) versus IMRT for anal cancer. Methods: We performed a single-institution retrospective review of all non-metastatic squamous cell carcinoma anal cancer patients treated between 2000-2011 using definitive chemoradiation with curative intent. Results: This study included 89 consecutive anal cancer patients (37 3DCRT, 52 IMRT). Median follow-up for all patients, IMRT patients alone, and CRT patients alone was 26.5 months (range, 3.5-133.6), 20 months (range, 3.5-125.5), and 61.9 months (range, 7.6-133.6), respectively. Three-year overall survival (OS), progression free survival (PFS), locoregional control (LRC), and colostomy free survival (CFS) were 91.1%, 82.3%, 90.8%, and 91.3% in the IMRT cohort and 86.1%, 72.5%, 91.9%, and 93.7% for the 3DCRT patients (all p>0.1). More patients in the 3DCRT group required a treatment break (11 vs. 4; p=0.006), although the difference in median treatment break duration was not significant (12.2 vs. 8.0 days; p=0.35). Survival outcomes did not differ based on whether a treatment break was required (all p>0.1). Acute grade ≥3 non-hematologic toxicity was significantly decreased in the IMRT cohort (21.1 vs. 59.5%; p<0.0001). Acute grade ≥3 skin toxicity was significantly worse in the 3DCRT group (p<0.0001) while an improvement in late grade ≥3 GI toxicity was observed in the IMRT patients (p=0.012). Conclusions: This is the largest retrospective review comparing 3DCRT and IMRT for definitive treatment of anal cancer. In contrast to previously published data, this study demonstrates that while long-term outcomes do not significantly differ based on RT technique, a marked decrease in adverse effects and the need for a treatment break can be achieved using IMRT.

scholarly journals Dynamic imaging response following radiation therapy predicts long-term outcomes for diffuse low-grade gliomas

2012 ◽  
Vol 14 (4) ◽  
pp. 496-505 ◽  
Author(s):  
J. Pallud ◽  
J.-F. Llitjos ◽  
F. Dhermain ◽  
P. Varlet ◽  
E. Dezamis ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Dynamic Imaging ◽  
Low Grade ◽  
Long Term Outcomes ◽  
Low Grade Gliomas ◽  
Imaging Response
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