scholarly journals Testosterone replacement therapy: role of pituitary and thyroid in diagnosis and treatment

2016 ◽  
Vol 5 (6) ◽  
pp. 850-858
Author(s):  
Megan Crawford ◽  
Laurence Kennedy
Keyword(s):  
Replacement Therapy ◽  
Diagnosis And Treatment ◽  
Testosterone Replacement ◽  
Testosterone Replacement Therapy

Testosterone Replacement Therapy in Males With Erectile Dysfunction

2011 ◽  
Vol 24 (3) ◽  
pp. 298-306 ◽  
Author(s):  
Bobby C. Jacob
Keyword(s):  
Erectile Dysfunction ◽  
Replacement Therapy ◽  
Common Factor ◽  
Serum Testosterone ◽  
Testosterone Replacement ◽  
Testosterone Replacement Therapy ◽  
Testosterone Deficiency ◽  
Global Estimates ◽  
The Relationship

Erectile dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Endogenous testosterone is critical for normal libido; however, studies have also demonstrated a potentially important role with respect to the erectile process. The prevalence of testosterone deficiency ranges from 1.7% to 35% in patients with ED, and age is a common factor linking ED and testosterone deficiency. By 2025, global estimates are that there will be 356 million men >65 years. Age-associated testosterone deficiency is characterized by symptoms such as ED, and low serum testosterone. Randomized, placebo controlled studies have established the utility of testosterone replacement therapy (TRT) for the restoration of serum testosterone levels to the normal range in hypogonadal males; however, well designed studies are limited with respect to specific evaluation of the role of TRT as monotherapy in improving erectile function. In addition, recent literature suggests a possible role for TRT in combination with phosphodiesterase-5 (PDE-5) inhibitors for men with ED. The following review describes the potential roles of testosterone in erectile physiology, examines the relationship between testosterone deficiency and ED, and reviews published literature evaluating the use of TRT in hypogonadal males with a diagnosis of ED.

scholarly journals Evolution of Guidelines for Testosterone Replacement Therapy

2019 ◽  
Vol 8 (3) ◽  
pp. 410 ◽  
Author(s):  
Hyun Park ◽  
Sun Ahn ◽  
Du Moon
Keyword(s):  
Clinical Practice ◽  
Replacement Therapy ◽  
Clinical Symptoms ◽  
Serum Testosterone ◽  
Diagnosis And Treatment ◽  
Testosterone Replacement ◽  
Testosterone Replacement Therapy ◽  
Testosterone Deficiency ◽  
Developmental Growth

Testosterone is an essential hormone required for the developmental growth and maintenance of the male phenotype during the whole life. With the increasing male life expectancy worldwide and development of adequate testosterone preparations, the prescription of testosterone has increased tremendously. Testosterone replacement should be based on low serum testosterone and related clinical symptoms. In the last two decades, with the accumulation of data, official recommendations have evolved in terms of definition, diagnosis, treatment, and follow-up. In practice, it is better for physicians to follow the Institutional Official Recommendations or Clinical Practice Guideline for an adequate diagnosis and treatment of testosterone deficiency. Currently, four official recommendations are available for diagnosis and treatment of patients with testosterone deficiency. The inconsistencies in the guidelines merely create confusion among the physicians instead of providing clear information. Furthermore, there is no definite method to assess serum testosterone and clinical symptoms. In the era of active testosterone replacement therapy (TRT), physicians’ practice patterns should be consistent with the clinical practice guidelines to avoid the misuse of testosterone. In this review, the author introduces the evolution of clinical guidelines to provide a comprehensive understanding of the differences and controversies with respect to TRT.

scholarly journals A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures

2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Suhaib Radi ◽  
Andrew C. Karaplis
Keyword(s):  
Bone Mass ◽  
Replacement Therapy ◽  
Fragility Fractures ◽  
Testosterone Replacement ◽  
Vertebral Compression Fractures ◽  
Testosterone Replacement Therapy ◽  
Male Hypogonadism ◽  
Mineral Density ◽  
Compression Fractures

While the contributing role of testosterone to bone health is rather modest compared to other factors such as estradiol levels, male hypogonadism is associated with low bone mass and fragility fractures. Along with stimulating physical puberty by achieving virilization and a normal muscle mass and improving psychosocial wellbeing, the goals of testosterone replacement therapy in male hypogonadism also include attainment of age-specific bone mineral density. We report on a 37-year-old man who presented with multiple vertebral compression fractures several years following termination of testosterone replacement therapy for presumed constitutional delay in growth and puberty. Here, we discuss the management of congenital hypogonadotropic hypogonadism with hyposmia (Kallmann syndrome), with which the patient was ultimately diagnosed, the role of androgens in the acquisition of bone mass during puberty and its maintenance thereafter, and outline specific management strategies for patients with hypogonadism and high risk for fragility fractures.

scholarly journals The role of testosterone replacement therapy and statin use, and their combination, in prostate cancer

2021 ◽  
Author(s):  
David S. Lopez ◽  
Danmeng Huang ◽  
Konstantinos K. Tsilidis ◽  
Steven Canfield ◽  
Mohit Khera ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Replacement Therapy ◽  
Testosterone Replacement ◽  
Testosterone Replacement Therapy ◽  
Statin Use
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