scholarly journals Evaluation of platelet-rich plasma from diabetic donors shows increased platelet vascular endothelial growth factor release

2019 ◽  
Vol 6 ◽  
pp. 43-43 ◽  
Author(s):  
Karina ◽  
Komang Ardi Wahyuningsih ◽  
Siti Sobariah ◽  
Iis Rosliana ◽  
Imam Rosadi ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Platelet Rich Plasma ◽  
Vascular Endothelial ◽  
Growth Factor Release ◽  
Endothelial Growth Factor ◽  
Factor Release

scholarly journals Assessment of Vascular Endothelial Growth Factor in Fresh versus Frozen Platelet Rich Plasma

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Nada Hosny ◽  
Fikry Goubran ◽  
Basma BadrEldin Hasan ◽  
Noha Kamel
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Calcium Gluconate ◽  
Platelet Rich Plasma ◽  
Vascular Endothelial ◽  
High Concentration ◽  
Significant Difference ◽  
Growth Factor Release ◽  
Endothelial Growth Factor ◽  
Vegf Release

Platelet rich plasma (PRP) is hemoconcentration with platelets concentration above baseline values and high concentration of many growth factors. The aim of this study was to assess freezing effect on vascular endothelial growth factor (VEGF) release from PRP using two different activation methods to simplify its use in different clinical applications. PRP was prepared using two-centrifugation steps method from 12 qualified blood donors. VEGF concentrations were measured in fresh PRP and after freezing/thawing for one and three weeks with two methods of activation using (i) calcium gluconate and (ii) calcium gluconate and thrombin. Platelets count was significantly increased compared to baseline whole blood values in all fresh and frozen PRP samples (p value was <0.05). No significant difference was found between VEGF concentrations after activating fresh and frozen-thawed PRP samples for one and three weeks by calcium alone or calcium with thrombin, and also no significant difference was found when freezing period was extended from one to three weeks. Our results showed that platelets count does not correlate with variable levels of VEGF. PRP could be prepared once and preserved frozen for at least three weeks for the next treatment sessions and activation with thrombin addition to calcium will not augment the growth factor release.

Sirolimus Toxicity and Vascular Endothelial Growth Factor Release From Islet and Renal Cell Lines

2007 ◽  
Vol 83 (12) ◽  
pp. 1635-1638 ◽  
Author(s):  
Matthew Laugharne ◽  
Sarah Cross ◽  
Sarah Richards ◽  
Charlotte Dawson ◽  
Laura Ilchyshyn ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cell Lines ◽  
Renal Cell ◽  
Vascular Endothelial ◽  
Growth Factor Release ◽  
Endothelial Growth Factor ◽  
Renal Cell Lines ◽  
Factor Release
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