scholarly journals Platelet lysate for COVID-19 pneumonia—a newer adjunctive therapeutic avenue

2021 ◽  
Vol 8 ◽  
pp. 11-11
Author(s):  
Madhan Jeyaraman ◽  
Sathish Muthu ◽  
Manish Khanna ◽  
Rashmi Jain ◽  
Talagavadi Channaiah Anudeep ◽  
...  
Keyword(s):  
Platelet Lysate ◽  
Therapeutic Avenue

scholarly journals Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair

2019 ◽  
Vol 14 (3) ◽  
pp. 034104 ◽  
Author(s):  
Raquel Costa-Almeida ◽  
Isabel Calejo ◽  
Roberta Altieri ◽  
Rui M A Domingues ◽  
Emanuele Giordano ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Platelet Lysate ◽  
Cell Delivery

scholarly journals Human platelet lysate delivered via an ocular wound chamber for the treatment of corneal epithelial injuries

2021 ◽  
Vol 206 ◽  
pp. 108493
Author(s):  
Gina L. Griffith ◽  
Andrew W. Holt ◽  
Elof Eriksson ◽  
Anthony J. Johnson ◽  
Jennifer S. McDaniel
Keyword(s):  
Human Platelet ◽  
Platelet Lysate ◽  
Corneal Epithelial ◽  
Human Platelet Lysate

scholarly journals The Effect of a Polyester Nanofibrous Membrane with a Fibrin-Platelet Lysate Coating on Keratinocytes and Endothelial Cells in a Co-Culture System

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 457
Author(s):  
Andreu Blanquer ◽  
Jana Musilkova ◽  
Elena Filova ◽  
Johanka Taborska ◽  
Eduard Brynda ◽  
...  
Keyword(s):  
Wound Healing ◽  
Endothelial Cells ◽  
Chronic Wounds ◽  
Human Keratinocytes ◽  
Skin Wound ◽  
Platelet Lysate ◽  
Therapeutic Approaches ◽  
Skin Wound Healing ◽  
New Therapeutic Approaches ◽  
Proliferation And Differentiation

Chronic wounds affect millions of patients worldwide, and it is estimated that this number will increase steadily in the future due to population ageing. The research of new therapeutic approaches to wound healing includes the development of nanofibrous meshes and the use of platelet lysate (PL) to stimulate skin regeneration. This study considers a combination of a degradable electrospun nanofibrous blend of poly(L-lactide-co-ε-caprolactone) and poly(ε-caprolactone) (PLCL/PCL) membranes (NF) and fibrin loaded with various concentrations of PL aimed at the development of bioactive skin wound healing dressings. The cytocompatibility of the NF membranes, as well as the effect of PL, was evaluated in both monocultures and co-cultures of human keratinocytes and human endothelial cells. We determined that the keratinocytes were able to adhere on all the membranes, and their increased proliferation and differentiation was observed on the membranes that contained fibrin with at least 50% of PL (Fbg + PL) after 14 days. With respect to the co-culture experiments, the membranes with fibrin with 20% of PL were observed to enhance the metabolic activity of endothelial cells and their migration, and the proliferation and differentiation of keratinocytes. The results suggest that the newly developed NF combined with fibrin and PL, described in the study, provides a promising dressing for chronic wound healing purposes.

scholarly journals Platelet-Lysate-Expanded Mesenchymal Stromal Cells for the Treatment of Resistant GVHD

2011 ◽  
Vol 17 (2) ◽  
pp. S169
Author(s):  
G. Lucchini ◽  
E. Dander ◽  
A. Rovelli ◽  
A. Balduzzi ◽  
S. Bonanomi ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Platelet Lysate
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