AB150. 73. Systematic review & meta-analysis of randomised control trials comparing stapled haemorrhoidectomy (SH) versus transanal haemorrhoidal dearterialization (THD) for treatment of haemorrhoidal disease

2018 ◽  
Vol 2 ◽  
pp. AB150-AB150
Author(s):  
Yasir Bashir ◽  
Qurat Ul Ain ◽  
David Mockler ◽  
Emmanuel Eguare
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Haemorrhoidal Disease ◽  
Stapled Haemorrhoidectomy ◽  
Randomised Control Trials ◽  
Transanal Haemorrhoidal Dearterialization

Efficacy of NSAIDs versus radiotherapy for heterotopic ossification prophylaxis following total hip arthroplasty in high-risk patients: a systematic review and meta-analysis

2021 ◽  
pp. 112070002199111
Author(s):  
Jacob Shapira ◽  
Mitchell J Yelton ◽  
Jeffery W Chen ◽  
Philip J Rosinsky ◽  
David R Maldonado ◽  
...  
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Meta Analysis ◽  
Comparable Efficacy ◽  
Total Hip ◽  
High Risk Patients ◽  
Randomised Control Trials ◽  
Risk Patients

Background: The aims of this systematic review were: (1) to investigate the prophylactic effect of radiotherapy (RT) and NSAIDs in high-risk patients following total hip arthroplasty (THA); and (2) to compare the efficacy of non-selective and COX-II selective NSAIDs in preventing post-THA HO, utilising a meta-analysis of randomised control studies. Methods: The PubMed, Embase, and Cochrane Databases were searched for articles regarding HO following THA in March 2019. Studies were included if they contained data regarding HO incidence after THA or contained data regarding HO prophylaxis comparison of NSAIDs and/or RT in terms of dosage or duration. Results: 24 studies reported on populations that were not at high-risk for HO. These studies reported between 47.3% and 90.4% of their patient populations had no HO formation; between 2.8% and 52.7% had mild formation; and between 0.0% and 10.4% had severe formation. A total of 13 studies reported on populations at high-risk for HO. Studies analysing RT in high-risk patients reported between 28.6% and 97.4% of patients developed no HO formation; between 1.9% and 66.7% developed mild HO formation; and between 0.0% and 11.9% developed severe HO formation. Studies analysing NSAID treatment among high-risk populations reported between 76.6% and 88.9% had no HO formation; between 11.1% and 23.4% had mild HO formation, and between 0.0% and 1.8% had severe HO formation. 9 studies were identified as randomised control trials and subsequently used for meta-analysis. The relative risk for COX-II in developing any HO after THA was not significantly different compared to non-selective NSAIDs (RR 1.00; CI, 0.801–1.256; p = 0.489). Conclusions: NSAIDs prophylaxis for HO may have better efficacy than RT in high-risk patients following THA. Non-selective and COX-II selective NSAIDs have comparable efficacy in preventing HO. Factors such as medical comorbidities and side-effect profile should dictate the prophylaxis recommendation.

Sertraline as a treatment for PTSD: a systematic review and meta-analysis

2004 ◽  
Vol 21 (3) ◽  
pp. 100-103 ◽  
Author(s):  
Paul Mooney ◽  
Janette Oakley ◽  
Michael Ferriter ◽  
Raymond Travers
Keyword(s):  
Systematic Review ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Meta Analysis ◽  
Case Series ◽  
Group Differences ◽  
Post Traumatic Stress ◽  
Relevant Research ◽  
Randomised Control Trials ◽  
Post Traumatic

AbstractObjective: Post-traumatic stress disorder (PTSD) is one of the most prevalent psychological disorders. Methods to alleviate its symptoms range from ‘talking therapies’ to pharmaceutical interventions. Our objective was to carry out a systematic review of the effectiveness of sertraline, an SSRI, as a treatment for PTSD.Method: Databases were searched to identify relevant research on sertraline as a treatment for PTSD.Results: Five randomised control trials were identified, along with seven open trials and case series studies.Conclusions: The review and meta-analysis supported the use of sertraline for PTSD though further research on sub-group differences (eg. gender) is required.

scholarly journals Is ultrasound-guided lavage an effective intervention for rotator cuff calcific tendinopathy? A systematic review with a meta-analysis of randomised controlled trials

2019 ◽  
Vol 5 (1) ◽  
pp. e000506 ◽  
Author(s):  
Simon Lafrance ◽  
Patrick Doiron-Cadrin ◽  
Marie Saulnier ◽  
Martin Lamontagne ◽  
Nathalie J Bureau ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rotator Cuff ◽  
Corticosteroid Injection ◽  
Meta Analysis ◽  
Bibliographic Databases ◽  
Ultrasound Guided ◽  
Calcific Tendinopathy ◽  
Shockwave Therapy ◽  
Randomised Control Trials

BackgroundRotator cuff calcific tendinopathy is characterised by the deposition of hydroxyapatite crystals in one of the rotator cuff tendons and can be managed by ultrasound-guided lavage. However, evidence regarding the efficacy of ultrasound-guided lavage for rotator cuff calcific tendinopathy remains inconclusive. The aim of this systematic review and meta-analysis is to update the available evidence on the efficacy of ultrasound-guided lavage in adults with rotator cuff calcific tendinopathy.MethodsA literature search was conducted up to April 2018 in four bibliographic databases to identify randomised control trials that compared ultrasound-guided lavage alone with other interventions to treat rotator cuff calcific tendinopathy. Randomised control trials were assessed with the Cochrane Risk of Bias Tool. Meta-analyses and/or qualitative synthesis of the evidence were performed.ResultsThree randomised control trials were included. Pooled results for pain (n=226) indicated that ultrasound-guided lavage may significantly decrease pain when compared with shockwave therapy, with a mean difference of −1.98 out of 10 points (95% CI −2.52 to −1.45) in the short term and of −1.84 (95% CI −2.63 to −1.04) in the long term. Based on one trial (n=25), ultrasound-guided lavage significantly improved function when compared with shockwave therapy (p<0.05). Based on another trial (n=48), the addition of ultrasound-guided lavage to a corticosteroid injection significantly improves function in the long term (p<0.05).ConclusionFor individuals with rotator cuff calcific tendinopathy, low-quality evidence suggests that ultrasound-guided lavage is more effective than shockwave therapy or a corticosteroid injection alone. Future trials could modify the present conclusions.Trial registration numberCRD42018095858.

scholarly journals The effect of walking on risk factors for cardiovascular disease: An updated systematic review and meta-analysis of randomised control trials

2015 ◽  
Vol 72 ◽  
pp. 34-43 ◽  
Author(s):  
Elaine M. Murtagh ◽  
Linda Nichols ◽  
Mohammed A. Mohammed ◽  
Roger Holder ◽  
Alan M. Nevill ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Cardiovascular Disease ◽  
Meta Analysis ◽  
Randomised Control Trials

Marginal Accuracy of Milled Versus Cast Cobalt Chromium Alloys in Long Span Implant-Supported Frameworks: A Systematic Review and Meta-analysis

2020 ◽  
Vol 11 (2) ◽  
pp. 120-127
Author(s):  
Simone Shah ◽  
Deepak Nallaswamy ◽  
Dhanraj Ganapathy
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Cobalt Chromium ◽  
Exclusion Criteria ◽  
Long Span ◽  
Electronic Search ◽  
Chromium Alloys ◽  
Randomised Control Trials ◽  
Larger Sample

Aim: To assess if milled cobalt chromium (Co-Cr) alloy offers significantly better marginal accuracy than cast Co-Cr alloy for screw-retained long-span dental implant framework. Materials and Methods: A search PICO was formulated using suitable keywords and an electronic search was initiated. The databases of PubMed, Cochrane Library, Google Scholar and Embase were searched for related articles. Bibliographies of randomised control trials and reviews, identified in the electronic search, were analysed for studies published outside the electronically searched journals. Electronic search identified 26 studies. A total of 16 studies were eliminated after reading the abstracts. Out of the remaining 10 studies, 3 were eliminated based on the inclusion and exclusion criteria, and finally 7 studies were finalised for systematic review. Results Data were extracted from the included studies and analysed. The obtained data were suitable for meta-analysis, which showed an overall effect size z = 4.97 ( P < .001) at 95% CI showing a significant statistical difference between milled and cast Co-Cr frameworks. Conclusion: Milled cobalt chromium frameworks are significantly more accurate than cast frameworks for long-span implant-supported frameworks used in dental prosthetic rehabilitation. More randomized controlled trials need to be conducted with a larger sample size to get a more authentic conclusion in a clinical scenario.

scholarly journals Acceptance, adherence and dropout rates of individuals with COPD approached in telehealth interventions: a protocol for systematic review and meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. e026794 ◽  
Author(s):  
Saeed Mardy Alghamdi ◽  
Tania Janaudis-Ferreira ◽  
Rehab Alhasani ◽  
Sara Ahmed
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Hospital Readmissions ◽  
Dropout Rates ◽  
Cochrane Library ◽  
Chronic Obstructive ◽  
Related Factors ◽  
Obstructive Pulmonary Disease ◽  
Randomised Control Trials ◽  
The Impact

IntroductionTelehealth interventions have the potential of improving exacerbation and health outcomes for individuals with chronic obstructive pulmonary disease (COPD), by delivering care in between clinical visits. However, the precise impact on avoiding exacerbation and reducing the incidence of hospital readmissions remains inconclusive. This lack of knowledge on the effectiveness of telehealth for COPD care might be due to non-adherence or partial adherence to intervention programmes and/or the withdrawal of participants over the course of previous studies.ObjectivesTo conduct a systematic review of trials of telehealth interventions (including randomised control trials (RCT), crossover and pre-post studies) to: (1) estimate the acceptance, adherence and dropout rates; (2) identify the reasons for dropout from telehealth interventions among individuals with COPD; (3) evaluate the impact of trial-related, sociodemographic and intervention-related factors on the acceptance, adherence and dropout rates and (4) estimate the extent to which the acceptance, adherence and dropout rates impact outcomes in comparison with usual monitoring.Methods and analysisA systematic literature review of four databases from earliest records to November 2018 will be carried out using CINAHL, Medline (Ovid), Cochrane Library and Embase. Randomised and non-randomised control studies will be included, in addition to crossover and pre-studies post-studies comparing telehealth with standard monitoring among individuals with COPD only. Two independent reviewers will screen all relevant abstracts and full-text studies to determine eligibility, assess the risk of bias and extract the data using structured forms. If the included studies are sufficiently homogenous in terms of interventions, populations and objectives, a meta-analysis will be performed.Ethics and disseminationEthical considerations are not required for this research.Trial registration numberCRD42017078541.

scholarly journals The efficacy and safety of liraglutide in the obese, non-diabetic individuals: a systematic review and meta-analysis

2019 ◽  
Vol 19 (3) ◽  
pp. 2591-2599
Author(s):  
Pei Zhang ◽  
Yu Liu ◽  
Yuan Ren ◽  
Jie Bai ◽  
Guangzhen Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Weight Loss ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
End Points ◽  
Safe Treatment ◽  
Randomised Control Trials ◽  
Safety Assessments ◽  
Treatment Of Obesity

Background: Liraglutide has been shown to improve glucose tolerance and lose weight in individuals with type 2 diabetes. To date, no meta-analysis of liraglutide’s safety and efficacy in individuals without diabetes has been conducted.Objectives: The aim of this study is to carry out a meta-analysis to assess the efficacy and safety of liraglutide in the obese, non-diabetic individuals.Methods: A literature review was performed to identify all published randomised control trials (RCT) of liraglutide for the treatment of obesity in non-diabetic individuals. The search included the following databases: EMBASE, MEDLINE and the Cochrane Controlled Trials Register.Results: We included five publications involving a total of 4,754 patients that compared liraglutide with placebo and found that liraglutide to be an effective and safe treatment for weight loss in individuals without diabetes. Primary efficacy end points: mean weight loss (MD = -5.52, 95% CI = -5.93 to -5.11, p<0.00001); lost more than 5% of body weight (OR = 5.46, 95% CI=3.57 to 8.34, p<0.00001) and key secondary efficacy end points: SBP decreased (the MD = -2.56, 95% CI = -3.28 to -1.84, p<0.00001). Safety assessments included the proportion of individuals who were withdrawn due to AE (OR = 2.85, 95% CI= 0.84 to 9.62, p=0.009), and nausea indicated that liraglutide was well tolerated. Conclusion: This systematic review and meta-analysis indicates that liraglutide to be an effective and safe treatment for weight loss in the obese, non-diabetic individuals.Keywords: liraglutide, weight loss, meta-analysis.

scholarly journals β-Blockers in sepsis: protocol for a systematic review and meta-analysis of randomised control trials

BMJ Open ◽  
2016 ◽  
Vol 6 (6) ◽  
pp. e012466 ◽  
Author(s):  
Erick H Duan ◽  
Simon J W Oczkowski ◽  
Emilie Belley-Cote ◽  
Richard Whitlock ◽  
Francois Lamontagne ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Randomised Control Trials ◽  
Β Blockers
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