scholarly journals AB060. SOH21AS258. The prognostic value of metabolomics with genomic single nucleotide polymorphism cross-talk for colorectal cancer recurrence and 5-year overall survival

2021 ◽  
Vol 5 ◽  
pp. AB060-AB060
Author(s):  
Christina Fleming ◽  
Helen Mohan ◽  
Donal Peter O’Leary ◽  
Jennifer Kirwan ◽  
Henry Redmond
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Single Nucleotide Polymorphism ◽  
Cross Talk ◽  
Prognostic Value ◽  
Cancer Recurrence ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Colorectal Cancer Recurrence

Association of rs7372209 single nucleotide polymorphism in gene for miRNA-26a-1 with tumor localization and disease outcome in patients with colorectal cancer from Bulgaria.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13656-e13656
Author(s):  
Galya Mihaylova ◽  
Desislava Ivanova ◽  
Oscan Tasinov ◽  
Neshe Nazifova-Tasinova ◽  
Veneta Petrova ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Overall Survival ◽  
Single Nucleotide Polymorphism ◽  
Healthy Volunteers ◽  
Predictive Biomarker ◽  
High Serum ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Expression Levels

e13656 Background: A retrospective study was carried out to investigate the association of functional rs7372209 single nucleotide polymorphism (SNP) in the 5'- region of pri-miRNA- 26a1 gene with a risk of colorectal cancer (CRC) in a Bulgarian population, to evaluate its role as a potential prognostic or predictive biomarker for the disease and to studied its affection on the expression of miRNA-26a-1 in patients with CRC. Methods: 101 patients with colorectal metastatic disease and 90 healthy volunteers, all Caucasians from Bulgaria, were genotyped for rs7372209 SNP by qPCR method. The expression levels of miRNA-26a in sera also have been determined. U6 was used as endogenous constitutively expressed control. Relative gene expression was calculated using 2−∆∆Ct method. Results: TT genotype in rs7372209 SNP was significantly overrepresented in CRC patients with right-sided colon cancer when compared with CRC patients with left-sided colon cancer, and rectal cancer (33% vs. 8%, OR = 6.13, 95% CI: 1.56–23.97, p = 0.009). Patients with TT genotype in rs7372209 SNP had significantly (p = 0.041) longer mean overall survival (OS) of 26 months (95% CI: 21.76–34.18) as compared to those with CT and CC genotypes – 19 months (95% CI: 16.43–22.20). Expression levels of miR-26a in sera were significantly higher in CRC patients compared to healthy volunteers. The ROC analysis revealed that miR-26a can effectively discriminate between CRC patients and the healthy volunteers (AUC = 0.830, 95% CI: 0.77–0.89, p < 0.001). Patients with TT genotype in rs7372209 SNP had a numeric lower mean level of miR-26a-1 – 4.702 in comparison with patients that harboring CT or CC genotype – 6.507. Conclusions: Our data suggest that high serum levels of miR-26a-1 are potentially useful as a diagnostic biomarker for CRC. Although, that patients with ТТ genotype had often more aggressive right-sided colon cancer they had longer mean overall survival than patients harboring CT or CC genotype of rs7372209.

scholarly journals EP-2306: Prognostic value of PCI and single nucleotide polymorphism rs4803455 of TGFß1 gene in SCLC

2018 ◽  
Vol 127 ◽  
pp. S1272-S1273
Author(s):  
P. Ayala ◽  
J. Cacicedo ◽  
D. Delgado ◽  
J.M. Nieto-Guerrero ◽  
D. Herrero ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Prognostic Value ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals Single Nucleotide Polymorphism Facilitated Down-Regulation of the Cohesin Stromal Antigen-1: Implications for Colorectal Cancer Racial Disparities

Neoplasia ◽  
2018 ◽  
Vol 20 (3) ◽  
pp. 289-294 ◽  
Author(s):  
Somenath Datta ◽  
Richard M. Sherva ◽  
Mart De La Cruz ◽  
Michelle T. Long ◽  
Priya Roy ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Single Nucleotide Polymorphism ◽  
Racial Disparities ◽  
Nucleotide Polymorphism ◽  
Down Regulation ◽  
Single Nucleotide

scholarly journals A single nucleotide polymorphism in the human PIGK gene associates with low PIGK expression in colorectal cancer patients

2012 ◽  
Vol 41 (4) ◽  
pp. 1405-1410 ◽  
Author(s):  
SANTANU DASGUPTA ◽  
PRODIPTO PAL ◽  
NITAI D. MUKHOPADHYAY ◽  
YUMEI FU ◽  
EDWARD A. RATOVITSKI ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Single Nucleotide Polymorphism ◽  
Cancer Patients ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Colorectal Cancer Patients
Sign in / Sign up

Export Citation Format

Share Document