scholarly journals Long term responders to palliative chemotherapy for advanced biliary tract cancer

2017 ◽  
Vol 8 (2) ◽  
pp. 352-360 ◽  
Author(s):  
Mark K. Doherty ◽  
Mairéad G. McNamara ◽  
Priya Aneja ◽  
Emma McInerney ◽  
Stephanie Moignard ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Palliative Chemotherapy ◽  
Tract Cancer

scholarly journals Long-term responders to palliative chemotherapy for advanced biliary tract cancer.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 391-391 ◽  
Author(s):  
Mark Doherty ◽  
Mairead G McNamara ◽  
Priya Aneja ◽  
Anne M. Horgan ◽  
Raymond Woo-Jun Jang ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Palliative Chemotherapy ◽  
Progression Free Survival ◽  
Analysis Data ◽  
First Line ◽  
Tract Cancer ◽  
Tumour Shrinkage ◽  
Third Line

391 Background: Standard palliative chemotherapy (PC) in patients (pts) with Advanced Biliary Tract Cancer (ABTC) since publication of ABC-02 study in 2010 is cisplatin/gemcitabine (cis/gem), with median overall survival (OS) of 11.7 months. Prior to this, institutional standard was gemcitabine/fluoropyrimidine combination. From the ABC-02 study, 8 cycles of PC is standard. Some pts benefit from continuing PC longer than 8 cycles. Methods: Pts treated for ABTC in Princess Margaret Cancer Centre between 06/1987 and 09/2015, receiving > 8 cycles of PC were included for analysis. Data was collected on demographics, clinicopathologic features, PC regimen, toxicities, and survival. Results: Of 553 pts who received PC, 119 pts met inclusion criteria of PC > 8 cycles. Median age was 60 (range 27-80). Site of tumour was ampullary in 11, distal bile duct in 14, gallbladder in 28, intrahepatic in 37, perihilar in 26, and unspecified in 3 pts. 61 (51%) required biliary stenting. 30 (25%) had definitive surgical resection at diagnosis, while 89 (75%) presented with ABTC. First-line PC regimens were cis/gem in 44 and gemcitabine/capecitabine in 62. Other regimens included gemcitabine and 5-fluorouracil alone or combined. Median time on first line PC was 10 months, with median of 12 cycles (range 9-47). 22 pts (19%) had treatment breaks > 8 weeks then restarted same PC. Any tumour shrinkage was seen in 73 pts (61%). The majority of pts discontinued PC due to disease progression (69), however 16 stopped due to toxicity such as thrombocytopenia, neutropenia, fatigue and neuropathy. At time of analysis, 103 pts had progressive disease, with median progression free survival of 11.8 months. 51 and 21 pts received second and third line chemotherapy, respectively. 27 pts are alive; median OS for the whole group was 22 months (95%CI 18.7-27.3 months). Conclusions: A cohort of ABTC pts continued to derive benefit from chemotherapy beyond 8 cycles, with median OS considerably greater than that seen in clinical trials. Toxicities were mostly manageable, with treatment breaks from PC for relief of side-effects observed. Further exploration of factors prognostic and predictive for continued benefit from PC will be explored and updated at presentation.

scholarly journals Skeletal muscle depletion predicts survival of patients with advanced biliary tract cancer undergoing palliative chemotherapy

Oncotarget ◽  
2017 ◽  
Vol 8 (45) ◽  
pp. 79441-79452 ◽  
Author(s):  
Kyoung-Min Cho ◽  
Hyunkyung Park ◽  
Do-Youn Oh ◽  
Tae-Yong Kim ◽  
Kyung Hun Lee ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Palliative Chemotherapy ◽  
Tract Cancer

scholarly journals 195 – Comparison of Short- and Long-Term Outcomes Between Anatomical Subtypes of Resected Biliary Tract Cancer in a Western High-Volume Center

2019 ◽  
Vol 156 (6) ◽  
pp. S-1386
Author(s):  
Eva Roos ◽  
Marin Strijker ◽  
Lotte C. Franken ◽  
Olivier R. Busch ◽  
Jeanin E. Van Hooft ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
High Volume ◽  
Long Term Outcomes ◽  
Tract Cancer ◽  
High Volume Center ◽  
Short And Long Term

scholarly journals Comparison of short- and long-term outcomes between anatomical subtypes of resected biliary tract cancer in a Western high-volume center

HPB ◽  
2020 ◽  
Vol 22 (3) ◽  
pp. 405-414 ◽  
Author(s):  
Eva Roos ◽  
Marin Strijker ◽  
Lotte C. Franken ◽  
Olivier R. Busch ◽  
Jeanin E. van Hooft ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
High Volume ◽  
Long Term Outcomes ◽  
Tract Cancer ◽  
High Volume Center ◽  
Short And Long Term

Patient-Reported Outcomes of Patients With Advanced Biliary Tract Cancers Receiving Gemcitabine Plus Capecitabine: A Multicenter, Phase II Trial of the Swiss Group for Clinical Cancer Research

2008 ◽  
Vol 26 (22) ◽  
pp. 3702-3708 ◽  
Author(s):  
Dieter Koeberle ◽  
Piercarlo Saletti ◽  
Markus Borner ◽  
Daniela Gerber ◽  
Daniel Dietrich ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Patient Reported Outcomes ◽  
Palliative Chemotherapy ◽  
Hematologic Toxicity ◽  
Karnofsky Performance Score ◽  
Pain Intensity Score ◽  
Tract Cancer ◽  
Number Of Patients ◽  
Patient Reported

Purpose To evaluate the effects of palliative chemotherapy with gemcitabine plus capecitabine (GemCap) on patient-reported outcomes measured using clinical benefit response (CBR) and quality-of-life (QOL) measures in patients with advanced biliary tract cancer. Patients and Methods Patients had to manifest symptoms of advanced biliary tract cancer and have at least one of the following: impaired Karnofsky performance score (60 to 80), average analgesic consumption ≥ 10 mg of morphine equivalents per day, and average pain intensity score of ≥ 20 mm out of 100 mm. Treatment consisted of oral capecitabine 650 mg/m2 twice daily on days 1 through 14 plus gemcitabine 1,000 mg/m2 as a 30-minute infusion on days 1 and 8 every 3 weeks until progression. The primary end point was the number of patients categorized as having a CBR or stable CBR (SCBR) during the first three treatment cycles. Results Forty-four patients were enrolled (bile duct cancer, n = 36; gallbladder cancers, n = 8). The main grade 3 or 4 adverse events included hematologic toxicity and fatigue. After three cycles, 36% of patients achieved a CBR, and 34% achieved an SCBR. Over the full course of treatment, 57% of patients achieved a CBR, and 18% achieved an SCBR. Improved QOL was observed in patients with a CBR or SCBR. The objective response rate was 25%. Median time to progression and overall survival times were 7.2 months and 13.2 months, respectively. Conclusion Chemotherapy with GemCap is well tolerated and effective and leads to a high CBR rate. Patient-reported outcomes are useful for evaluating the effects of palliative chemotherapy in patients with biliary tract cancer.

The impact of age and comorbidity in advanced or recurrent biliary tract cancer receiving palliative chemotherapy

2020 ◽  
Vol 35 (10) ◽  
pp. 1828-1835
Author(s):  
Naminatsu Takahara ◽  
Yousuke Nakai ◽  
Kei Saito ◽  
Takashi Sasaki ◽  
Yukari Suzuki ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Palliative Chemotherapy ◽  
Tract Cancer ◽  
The Impact

scholarly journals Outcomes in patients receiving palliative chemotherapy for advanced biliary tract cancer

JHEP Reports ◽  
2021 ◽  
pp. 100417
Author(s):  
Felix Thol ◽  
Simon Johannes Gairing ◽  
Carolin Czauderna ◽  
Thomas Thomaidis ◽  
Thomas Gamstätter ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Palliative Chemotherapy ◽  
Tract Cancer
Sign in / Sign up

Export Citation Format

Share Document