scholarly journals Colorectal cancer anatomic distribution patterns remain the same after sessile serrated adenoma/polyp considered cancer precursor: a 9-year comparison study from community-based endoscopy centers

2016 ◽  
Vol 7 (6) ◽  
pp. 917-923 ◽  
Author(s):  
Juliana F. Yang ◽  
Amy E. Noffsinger ◽  
Deepak Agrawal ◽  
Qing-Hua Yang
Keyword(s):  
Colorectal Cancer ◽  
Distribution Patterns ◽  
Comparison Study ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Community Based ◽  
Anatomic Distribution

A Novel Pit Pattern Identifies the Precursor of Colorectal Cancer Derived From Sessile Serrated Adenoma

2012 ◽  
Vol 107 (3) ◽  
pp. 460-469 ◽  
Author(s):  
Tomoaki Kimura ◽  
Eiichiro Yamamoto ◽  
Hiro-o Yamano ◽  
Hiromu Suzuki ◽  
Seiko Kamimae ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Pit Pattern ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma

Significant difference of c-type lectin-like receptor 2 between colorectal cancer and polyp subgroups

2021 ◽  
pp. 1-7
Author(s):  
Meng-Lin Zhang ◽  
Wen-Juan Huang ◽  
Chen-Xi Yue ◽  
Ming-Ming Li ◽  
Na Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hyperplastic Polyp ◽  
Colorectal Polyps ◽  
Curve Analysis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Sessile Serrated Adenoma ◽  
Roc Curve Analysis ◽  
Serrated Adenoma ◽  
Node Metastasis ◽  
Significant Difference

BACKGROUND: Platelets play a key role in tumor progression and metastasis. C-type lectin-like receptor 2 (CLEC-2) is the receptor expressed on platelets and the marker of platelet activation. OBJECTIVE: This study aims to determine whether soluble CLEC-2 levels differ between patients with benign colorectal polyps and those with colorectal cancer (CRC). METHODS: We measured plasma soluble CLEC-2 by enzyme-linked immunosorbent assay in 150 patients with colorectal polyps, 150 CRC patients without metastasis, 150 CRC liver metastasis, and 150 control subjects. RESULTS: The CRC patients had higher soluble CLEC-2 levels than patients with colorectal polyps (p< 0.001). Moreover, CRC patients with liver metastases displayed higher CLEC-2 levels than those in CRC patients without metastases (p< 0.001). In the CRC patients, CLEC-2 levels were correlated with lymph node metastasis and advanced stage. In the patients with polyps, there was a significant difference in CLEC-2 levels among patients with hyperplastic polyp, sessile serrated adenoma, and traditional serrated adenoma (p< 0.001). The ROC curve analysis revealed CLEC-2 had an optimal sensitivity of 77.3% and specificity of 94.6% for the screening of CRC, and sensitivity of 71.0% and specificity of 76.7% for the differential diagnosis of colorectal polyps and CRC. CONCLUSIONS: CRC patients have higher CLEC-2 levels than patients with colorectal polyps and healthy controls. Moreover, there is a significant difference in CLEC-2 levels among polyp subtypes. Further research is warranted.

Anatomic Distribution of Sessile Serrated Adenoma/Polyp With and Without Cytologic Dysplasia

2015 ◽  
Vol 139 (3) ◽  
pp. 388-393 ◽  
Author(s):  
Juliana F. Yang ◽  
Shou-Jiang Tang ◽  
Richard H. Lash ◽  
Ruonan Wu ◽  
Qinghua Yang
Keyword(s):  
Distal Colon ◽  
Proximal Colon ◽  
Published Data ◽  
Low Grade ◽  
Ascending Colon ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Anatomic Distribution ◽  
Low Prevalence ◽  
Serrated Adenomas

Context Sessile serrated adenomas/polyps (SSA/Ps) have been increasingly studied during the last 10 years. However, their detailed anatomic distribution pattern has not been studied, especially given newer (broader) criteria for the diagnosis. Objectives To characterize the anatomic distribution of SSA/P with and without cytologic dysplasia and to assess the demographics of these patients in a nationwide database. Design We retrospectively analyzed the database of Miraca Life Sciences Research Institute for a 1-year period. Patients with a diagnosis of SSA/P, SSA/P with low-grade cytologic dysplasia (SSA/P-LGD), SSA/P with high-grade cytologic dysplasia (SSA/P-HGD), or SSA/P with adenocarcinoma (SSA/P-ACA) were retrieved, and patients' age, sex, and specific anatomic location were analyzed. Results A total of 11 201 patients were identified, of which 10 646 (95.0%) had SSA/P, 514 (4.6%) had SSA/P-LGD, 39 (0.35%) had SSA/P-HGD, and 2 (0.018%) had SSA/P-ACA. All SSA/Ps and more advanced lesions were significantly more common in the proximal colon—SSA/P (61.2%), SSA/P-LGD (61.2%), SSA/P-HGD (80%), and SSA/P-ACA (100%)—than in either the transverse (18.8%, 17.8%, 10.0%, and 0%, respectively) or the distal (19.9%, 21.0%, 10.0%, and 0%, respectively) colon, P &lt; .001. Sessile serrated adenoma/polyp with cytologic dysplasia was most commonly found in the ascending colon (LGD, 31.6%) and cecum (HGD, 37.5%). Advanced SSA/Ps were disproportionally more common among older women. Conclusions Sessile serrated adenomas/polyps with and without cytologic dysplasia and carcinoma are predominantly found in the cecum and ascending colon, whereas there is low prevalence in both the transverse and distal colon. Confirmation of previously published data regarding demographics of advanced lesions among a different cohort and including newer (broader) criteria suggests these criteria are valid.

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