Significant impact of cryopreserved amniotic membrane on acute ocular Stevens-Johnson syndrome and toxic epidermal necrolysis

2016 ◽  
Vol 1 ◽  
pp. 33-33
Author(s):  
Anny M. S. Cheng ◽  
Scheffer C. G. Tseng
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Amniotic Membrane ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome

Management of Acute Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Utilizing Amniotic Membrane and Topical Corticosteroids

2010 ◽  
Vol 149 (2) ◽  
pp. 203-213.e2 ◽  
Author(s):  
Maya C. Shammas ◽  
Edward C. Lai ◽  
Jayati S. Sarkar ◽  
Jennifer Yang ◽  
Christopher E. Starr ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Amniotic Membrane ◽  
Stevens Johnson Syndrome ◽  
Topical Corticosteroids ◽  
Johnson Syndrome

scholarly journals Clinical Aspects of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis With Severe Ocular Complications in Brazil

2021 ◽  
Vol 8 ◽  
Author(s):  
Tais Hitomi Wakamatsu ◽  
Myrna Serapião dos Santos ◽  
Telma Pereira Barreiro ◽  
Ana Estela Besteti Pires Ponce Sant'Anna ◽  
Fabíola Murta ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Amniotic Membrane ◽  
Ocular Surface ◽  
Minor Salivary Gland ◽  
European Ancestry ◽  
Stevens Johnson Syndrome ◽  
Clinical Aspects ◽  
Ocular Complications ◽  
Gram Positive ◽  
Johnson Syndrome

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute and potentially fatal inflammatory vesiculobullous reactions that affect the skin and mucous membranes, and which are most often triggered by particular medications and infections. In Brazil, the drugs most frequently associated with TEN and SJS include cold medicine such as dipyrone and NSAIDs, followed by carbamazepine, phenobarbital, penicillin, and allopurinol. Genetic variations have been found to increase the risk of SJS/TEN in response to triggering factors such as medications. The most closely associated genes found in Brazilian cold-medicine-related SJS/TEN patients with severe ocular complications are HLA-A*66:01 in those of mixed African and European ancestry and HLA-B*44:03 and HLA-C*12:03 in those of solely European ancestry. Our classification system for grading ocular surface complication severity in SJS/TEN patients revealed the most severe complications to be limbal stem cell deficiency and dry eye. Changes to the conjunctival flora have also been observed in SJS/TEN patients. Our group identified bacterial colonization in 95% of the eyes (55.5% of which were gram-positive cocci, 25.5% of which were gram-negative bacilli, and 19% of which were gram-positive bacilli). Several new treatment options in the acute and chronic ocular management of the SJS/TEN patients have been described. This article highlights some Brazilian institutions' contributions to ocular surface care in both the acute phase (including the use of amniotic membrane transplantation) and the chronic phase (such as eyelid margin and fornix reconstruction, minor salivary gland transplantation, amniotic membrane and limbal transplantation, scleral contact lenses, anti-angiogenic eyedrops for corneal neovascularization, ex-vivo cultivated limbal epithelium transplantation, conjunctival-limbal autografting, oral mucosa transplantation, and keratoprosthesis).

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