scholarly journals Comparative assessment of qualitative and quantitative perfusion with dual-energy CT and planar and SPECT-CT V/Q scanning in patients with chronic thromboembolic pulmonary hypertension

2018 ◽  
Vol 8 (4) ◽  
pp. 414-422 ◽  
Author(s):  
Rahul D. Renapurkar ◽  
Michael A. Bolen ◽  
Sankaran Shrikanthan ◽  
Jennifer Bullen ◽  
Wadih Karim ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Dual Energy ◽  
Comparative Assessment ◽  
Dual Energy Ct ◽  
Qualitative And Quantitative ◽  
Quantitative Perfusion ◽  
Thromboembolic Pulmonary Hypertension

scholarly journals Comparison of dual-energy computer tomography and dynamic contrast-enhanced MRI for evaluating lung perfusion defects in chronic thromboembolic pulmonary hypertension

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0251740
Author(s):  
Tawfik Moher Alsady ◽  
Till F. Kaireit ◽  
Lea Behrendt ◽  
Hinrich B. Winther ◽  
Karen M. Olsson ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Perfusion Defect ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Dual Energy ◽  
Lung Perfusion ◽  
Dual Energy Ct ◽  
Pulmonary Endarterectomy ◽  
Thromboembolic Pulmonary Hypertension ◽  
Perfusion Defects ◽  
Ct And Mri

Objectives To evaluate the agreement in detecting pulmonary perfusion defects in patients with chronic thromboembolic pulmonary hypertension using dual-energy CT and dynamic contrast-enhanced MRI. Second, to compare both imaging modalities in monitoring lung perfusion changes in these patients after undergoing pulmonary endarterectomy. Methods 20 patients were examined with CT and MRI before and/or after pulmonary endarterectomy. Estimated perfusion defect percentage from both modalities was compared in a lobe-based analysis. Spatial agreement of perfusion defect maps was also assessed. Results A significant correlation between CT and MRI based perfusion defect percentage was calculated in all lung lobes (r > 0.78; p < 0.001). In addition, a good spatial agreement between perfusion defect maps was found (mean spatial overlap for the whole lung was 68.2%; SD = 6.9). Both CT and MRI detected improvements in pulmonary perfusion after pulmonary endarterectomy: 8% and 7% decrease in whole lung perfusion defect percentage (p = 0.007 and 0.004), respectively. In a lobe-wise analysis, improvements were statistically significant only in lower lobes using both modalities (reduction in defect percentage ranged from 16–29%; p < 0.02). Conclusions Dual-energy CT is an alternative to MRI in monitoring chronic thromboembolic pulmonary hypertension. Both imaging modalities provided comparable estimations of perfusion defects and could detect similar improvement in lung perfusion after pulmonary endarterectomy.

scholarly journals Сomputed tomography in assessing the severity of patients with chronic thromboembolic pulmonary hypertension

2021 ◽  
Vol 27 (3) ◽  
pp. 333-340
Author(s):  
K. A. Pishchulov ◽  
M. A. Simakova ◽  
D. V. Karpova ◽  
O. M. Moiseeva
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Venous Blood ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Artery Aneurysm ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Mixed Venous Blood ◽  
Thromboembolic Pulmonary Hypertension ◽  
Score Index

Objective. To evaluate the role of computed tomography in the assessment of chronic thromboembolic pulmonary hypertension (CTEPH) severity. Design and methods. We included 41 patients. Chest dual-energy CT-computed tomographic angiography was performed according to the standard protocol and in some cases Dual Energy mode was used. The patients were divided into 2 groups: with proximal and distal types of pulmonary artery lesions. Results. Quanadli index and Score index showed a significant negative correlation with the value of cardiac output (CO) (r = –0,591, p < 0,05; r = –0,531, p < 0,001, respectively), mixed venous blood saturation (SvO2) (r = –0,457, p = 0,065; r = –0,595, p < 0,001, respectively). For the Score index, significant negative correlations were established with both the CO value: r = –0,531, p < 0,001, the SvO2 r = –0,595, p < 0,001, and with the N-terminal pro-B type natriuretic peptide (NTproBNP) value (r = –0,537, p = 0,003). Correlations are also found in the analysis within the compared groups. The Quanadli index correlated with the mean pressure in the pulmonary artery in the group with the proximal type of lesion (r = 0,825, p = 0,012). Pulmonary artery aneurysms were detected in 39 % (n = 16) patients. There was a positive correlation between the presence of a pulmonary artery aneurysm and the functional class of CTEPH (r = 0,526, p = 0,007) in patients with the distal lesion. Conclusions. Quanadli and Score indices are promising tools for CTEPH severity assessment.

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