scholarly journals Protective effects of recombinant human brain natriuretic peptide on the myocardial injury induced by acute carbon monoxide poisoning

2020 ◽  
Vol 10 (6) ◽  
pp. 1785-1794
Author(s):  
Na Li ◽  
Xun Gao ◽  
Weizhan Wang ◽  
Pu Wang ◽  
Baoyue Zhu
Keyword(s):  
Carbon Monoxide ◽  
Human Brain ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Myocardial Injury ◽  
Carbon Monoxide Poisoning ◽  
Protective Effects ◽  
Acute Carbon Monoxide Poisoning

scholarly journals Buyanghuanwu decoction inhibited TLR4-induced activation of nuclear factor-kappa B in acute carbon monoxide poisoning rats

2015 ◽  
Author(s):  
Weirong Li ◽  
Xiuwei Wang ◽  
Zhen Guan ◽  
Yufei Zheng ◽  
Xiaodong Zhang ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Nuclear Factor Kappa B ◽  
Carbon Monoxide Poisoning ◽  
Intragastric Administration ◽  
Protective Effects ◽  
Hippocampal Region ◽  
Acute Carbon Monoxide Poisoning ◽  
Tnf Α ◽  
Delayed Encephalopathy ◽  
Optimal Treatment Strategy

Acute carbon monoxide poisoning (ACMP) is one of the most common types of poisoning worldwide, and may result in delayed encephalopathy, however, its pathogenesis remains obscure and there is no optimal treatment strategy for the patients with ACMP. Here, we developed the ACMP rat model to observe the protective effects of Buyanghuanwu decoction (BYHWD) on hippocampal neuron. BYHWD (per 5 g/kg) were intragastric administration to rats twice each day for 28 days after ACMP. In ACMP + BYHWD group rats, the neuronal injury in the hippocampal region was significantly less than that of ACMP group’s. BYHWD of intragastric administration also markedly decreased the expression of the TLR4, MyD88, NF-κB P65 after acute carbon monoxide poisoning (P<0.05). TNF-α、IL-1β protein level in ACMP + BYHWD group was lower than that of ACMP group (P<0.05). Our results suggested that decreased the activation of TLR4- NF-κB signal pathway due to BYHWD may partially account for its effect of neuroprotection standing against ACMP, and inhibited the inflammatory reaction to promote the ability recovery of learning and memory in ACMP rats.

scholarly journals Myocardial Injury and Fibrosis From Acute Carbon Monoxide Poisoning

2021 ◽  
Author(s):  
Dong-Hyuk Cho ◽  
Sung Min Ko ◽  
Jung-Woo Son ◽  
Eung Joo Park ◽  
Yong Sung Cha
Keyword(s):  
Carbon Monoxide ◽  
Myocardial Injury ◽  
Carbon Monoxide Poisoning ◽  
Acute Carbon Monoxide Poisoning

scholarly journals Myocardial injury was associated with neurological sequelae of acute carbon monoxide poisoning in Taiwan

2018 ◽  
Vol 81 (8) ◽  
pp. 682-690 ◽  
Author(s):  
Mau-Sheng Lin ◽  
Chun-Chi Lin ◽  
Chen-Chang Yang ◽  
Shu-Chuan Weng ◽  
Shun-Mu Wang ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Myocardial Injury ◽  
Carbon Monoxide Poisoning ◽  
Neurological Sequelae ◽  
Acute Carbon Monoxide Poisoning

Usefulness of N-terminal pro-B-type natriuretic peptide (NT-ProBNP) as a marker for cardiotoxicity and comparison with echocardiography in paediatric carbon monoxide poisoning

2020 ◽  
Vol 30 (8) ◽  
pp. 1103-1108
Author(s):  
Caner Turan ◽  
Eser Dogan ◽  
Ali Yurtseven ◽  
Eylem Ulas Saz
Keyword(s):  
Carbon Monoxide ◽  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Natriuretic Peptide ◽  
Myocardial Injury ◽  
Carbon Monoxide Poisoning ◽  
Left Ventricular ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction

AbstractObjectives:To demonstrate the usefulness of N-Terminal Pro-B-Type natriuretic peptide (NT-proBNP) as an early biomarker of carbon monoxide-induced myocardial injury in children. It also aimed to identify the correlation between NT-proBNP and left ventricular systolic dysfunction findings shown by echocardiography.Methods:Prospective, observational study conducted at a paediatric emergency department between October 2017 and April 2019 which involved children aged 0–17 years. The patients were divided into three groups based on severity; mild, moderate and severe groups. The patient characteristics, carboxyhaemoglobin, CK-MB Mass (CKMB-M), troponin-T, and NT-proBNP levels were measured, and echocardiography was performed and left ventricular ejection fraction was measured.Results:Sixty-nine patients and 60 healthy controls were included. Male gender, younger age, higher carboxyhaemoglobin levels, and altered mental status were found as independent predictors of carbon monoxide-induced myocardial injury. If the cut-off value for NT-proBNP level is >480 pg/ml, the sensitivity–specificity for decreased left ventricular ejection fraction, which is the strongest carbon monoxide-induced myocardial injury sign, were 100–96%, respectively. A high negative correlation was found between NT-proBNP levels and left ventricular ejection fraction (r = −0.769, p < 0.01) in the carbon monoxide poisoning group, and there was a positive correlation between the carboxyhaemoglobin and NT-proBNP levels (r = 0.583, p < 0.01).Conclusion:Echocardiography is an ideal tool and very sensitive, but its routine use is limited due to its non-availability. An increased level of NT-proBNP (>480pg/ml) may be useful as an ideal biomarker for early detection of carbon monoxide-induced myocardial injury sign and reduced left ventricular ejection fraction which is the most crucial point in making a decision on hyperbaric oxygen therapy.

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