scholarly journals Resumé of the challenges and burden of living with transplanted hearts for >31 years

2021 ◽  
Vol 11 (1) ◽  
pp. 164-170
Author(s):  
Eva Maria Javier Delmo ◽  
Mariano Francisco del Maria Javier ◽  
Frank Wagner ◽  
Roland Hetzer
Keyword(s):  
Transplanted Hearts

An Adapted Process and Organ Procurement Perspective on Heart Retransplantation for a Healthy Heart’s Third Life

2021 ◽  
pp. 152692482110246
Author(s):  
Darryl C. Nethercot ◽  
Mita Shah ◽  
Lisa M. Stocks ◽  
Jeffrey M. Trageser ◽  
Victor Pretorius ◽  
...  
Keyword(s):  
United States ◽  
Organ Procurement ◽  
The United States ◽  
Matching Process ◽  
Organ Procurement Organizations ◽  
Third Person ◽  
Adapted Process ◽  
United Network ◽  
Transplanted Hearts

As organ procurement organizations nationwide see an increased opportunity to retransplant already transplanted hearts, we would like to share the overview and process of our 2 successful cases. Heart retransplantation increased our cardiac placement rates by 2.64% and 2% in 2015 and 2019, respectively. Spread across a nation that sees over 3500 heart placements annually, a 2% increase would be substantial. Since 2009, our cases stand as the only documented heart retransplantations in the United States. However, United Network for Organ Sharing data shows that potential exists. From a facilitation perspective, we have developed a protocol to ease the matching process. From a surgical perspective, these cases had no complications and saved 2 lives, with each heart now beating in a third person. We hope that by sharing our process and success, we can familiarize fellow organ procurement organizations and transplant communities with this viable opportunity.

MIG/CXCL9 neutralization attenuates chronic rejection of transplanted hearts

2003 ◽  
Vol 22 (1) ◽  
pp. S154
Author(s):  
D Whiting ◽  
S Chun ◽  
H Laks ◽  
J Yun ◽  
X Gan ◽  
...  
Keyword(s):  
Chronic Rejection ◽  
Transplanted Hearts

scholarly journals Favorable medium-term outcome of transplanted hearts selected from marginal donors by pharmacological stress echocardiography

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P5096-P5096
Author(s):  
T. Bombardini ◽  
S. Gherardi ◽  
G. Arpesella ◽  
M. Maccherini ◽  
W. Serra ◽  
...  
Keyword(s):  
Stress Echocardiography ◽  
Pharmacological Stress ◽  
Medium Term ◽  
Term Outcome ◽  
Marginal Donors ◽  
Transplanted Hearts

Proliferative Activity of Myocytes in Transplanted Hearts Investigated Using BrdU

1995 ◽  
Vol 752 (1 Cardiac Growt) ◽  
pp. 111-114
Author(s):  
C. LORETO ◽  
D. ARTICO ◽  
N. FINATO ◽  
C. A. BELTRAMI
Keyword(s):  
Proliferative Activity ◽  
Transplanted Hearts

Chronic rejection of transplanted hearts

2001 ◽  
Vol 6 (3) ◽  
pp. 205-210 ◽  
Author(s):  
James J. Yun ◽  
Michael P. Fischbein ◽  
Hillel Laks ◽  
Abbas Ardehali
Keyword(s):  
Chronic Rejection ◽  
Transplanted Hearts

Humoral factor(s) produced by pressure overload enhance cardiac hypertrophy and natriuretic peptide expression

1997 ◽  
Vol 273 (1) ◽  
pp. H113-H118 ◽  
Author(s):  
T. Iso ◽  
M. Arai ◽  
A. Wada ◽  
K. Kogure ◽  
T. Suzuki ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Natriuretic Peptide ◽  
Aortic Coarctation ◽  
Pressure Overload ◽  
Humoral Factor ◽  
Myosin Isoforms ◽  
Hypertrophic Response ◽  
Cardiac Atrophy ◽  
Transplanted Hearts

Chronic pressure overload is known to increase cardiac mass and expression levels of both atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) mRNAs. Although mechanical stretching of cardiac myocytes could cause these changes, humoral factor(s) secondary to pressure overload may also be involved. To dissociate humoral effects from the effects of mechanical loading on cardiac hypertrophic responses, we examined expression of ANP and BNP at both mRNA and protein levels and proportions of myosin isoforms in transplanted cervical hearts that were mechanically unloaded under conditions with or without hypertension by aortic coarctation. Seven days after transplantation, cardiac atrophy that usually occurs in transplanted hearts without hypertension by coarctation was prevented in the transplanted hearts with hypertension by coarctation. The levels of expression of ANP and BNP mRNAs were increased in the transplanted hearts with relative to those without hypertension by coarctation. The plasma level of angiotensin II was higher in rats with than without hypertension by coarctation. Plasma endothelin-1 levels were not significantly different between the two groups. In addition, levels of expression of ANP and BNP mRNAs were increased in the transplanted hearts without hypertension relative to those in the in situ hearts. The proportion of the V3 myosin isoform was also increased in the transplanted hearts without hypertension relative to the in situ hearts. These results indicate that humoral factor(s) secondary to the pressure overload produced by aortic coarctation enhanced the cardiac hypertrophic response and elevated the levels of mRNAs encoding these embryonic markers. Moreover, our findings regarding ANP and BNP expression in the transplanted hearts provide additional evidence that the fetal genes are reexpressed during the process of cardiac atrophy as well as in cardiac hypertrophy.

scholarly journals 1089-119 Pentoxifylline protects allogenic transplanted hearts

2004 ◽  
Vol 43 (5) ◽  
pp. A195
Author(s):  
Nour Eddine El Mokhtari ◽  
Alexander Reinecke ◽  
Bettina Dresske ◽  
Markus Lins ◽  
Dietmar Krueger ◽  
...  
Keyword(s):  
Transplanted Hearts
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