scholarly journals YAP-dependent metabolic remodeling in local lymph node boosts the function of cancer cells

Biotarget ◽  
2019 ◽  
Vol 3 ◽  
pp. 14-14 ◽  
Author(s):  
Toshihide Kashihara ◽  
Daniela Zablocki ◽  
Junichi Sadoshima
Keyword(s):  
Lymph Node ◽  
Cancer Cells ◽  
Metabolic Remodeling ◽  
Local Lymph Node

scholarly journals The Expression of Bcl-2 and BID in Gastric Cancer Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Mariusz Gryko ◽  
Anna Pryczynicz ◽  
Konrad Zareba ◽  
Bogusław Kędra ◽  
Andrzej Kemona ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Lymph Node ◽  
Cancer Cells ◽  
Clinicopathological Parameters ◽  
Gastric Cancer Cells ◽  
Study Objective ◽  
Node Metastases ◽  
Local Lymph Node ◽  
T4 Gastric Cancer

Background.Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence ofHelicobacter pyloriinfection, and patients’ survival.Materials and Methods.The study involved 88 patients operated on for gastric cancer. The expressions of Bcl-2 and BID were determined immunohistochemically.Results.Positive Bcl-2 expression was found in 55.7% and, BID in 53.6% of patients. The Bcl-2 expression correlated with stage pT3 and T4 gastric cancerP<0.05, with the intestinal type according to LaurenP<0.001, ulcerated type according to Bormann’s classificationP<0.01, and with local lymph node metastasesP<0.05.Conclusion.The Bcl-2 protein plays a key role in the process of gastric cancer formation and is associated with the growth of definite types of gastric cancer.

Interlaboratory Evaluation of the Local Lymph Node Assay with 25 Chemicals and Comparison with Guinea Pig Test Data

1991 ◽  
Vol 1 (1) ◽  
pp. 30-43 ◽  
Author(s):  
D. A. Basketter ◽  
E. W. Scholes ◽  
I. Kimber ◽  
P. A. Botham ◽  
J. Hilton ◽  
...  
Keyword(s):  
Lymph Node ◽  
Guinea Pig ◽  
Test Data ◽  
Local Lymph Node Assay ◽  
Local Lymph Node

scholarly journals HAND2-AS1 inhibits invasion and metastasis of cervical cancer cells via microRNA-330-5p-mediated LDOC1

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Shengcai Chen ◽  
Jing Wang
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Cells ◽  
Cell Counting ◽  
Luciferase Reporter ◽  
Invasion And Metastasis ◽  
Node Metastasis ◽  
Cervical Cancer Cells ◽  
Associated Proteins

Abstract Background Cervical cancer is a serious disease with complicated pathogenesis and thus there is an urgent need to find novel targets for the treatment. Recently, long non-coding RNAs (lncRNAs) have emerged as critical factors in tumorigenesis. In this study, we aimed to investigate the mechanism of HAND2 antisense RNA 1 (HAND2-AS1) on the invasion and metastasis of cervical cancer cells. Methods The expression patterns of HAND2-AS1, microRNA-330-5p (miR-330-5p) and leucine zipper down-regulated in cancer 1 (LDOC1) in cervical cancer were characterized by RT-qPCR and western blot analysis. Dual luciferase reporter assay and RIP were applied to verify relationship between HAND2-AS1, miR-330-5p and LDOC1. Fluorescence in situ hybridization (FISH) was used to detect the subcellular localization of HAND2-AS1. Besides, viability, invasion and migration ability of HeLa cells were investigated by cell counting kit-8 (CCK-8) and Transwell assays respectively. Hematoxylin–eosin staining was performed for lymph node metastasis detection. In addition, the tumor growth in nude mice was evaluated. Results Low expression of HAND2-AS1 and LDOC1, and high expression of miR-330-5p were detected in cervical cancer tissues and cells. It was found that binding of HAND2-AS1 to miR-330-5p results in upregulation of LDOC1 expression. Also, overexpressed HAND2-AS1 and LDOC1 or down-regulated miR-330-5p inhibited expression of proliferation-associated proteins Ki-67, PCNA, migration-associated proteins N-cad and invasion-related proteins MMP-2, MMP-9 as well as lymph node metastasis. Moreover, HAND2-AS1 inhibited tumor formation and lymph node metastasis by binding to miR-330-5p in vivo. Conclusion HAND2-AS1 promotes LDOC1 expression by competitively binding to miR-330-5p and consequently inhibiting cervical cancer cell invasion and metastasis. This could facilitate development of therapeutic strategies against cervical cancer.

scholarly journals Cancer Cells Regulate Lymphocyte Recruitment and Leukocyte-Endothelium Interactions in the Tumor-Draining Lymph Node

2005 ◽  
Vol 65 (24) ◽  
pp. 11639-11648 ◽  
Author(s):  
Virginie Carrière ◽  
Renaud Colisson ◽  
Carine Jiguet-Jiglaire ◽  
Elisabeth Bellard ◽  
Gérard Bouche ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cancer Cells ◽  
Draining Lymph Node ◽  
Tumor Draining Lymph Node

Investigation of the Dermal Sensitizing Potential of Traditional Medical Extracts in Local Lymph Node Assays

2009 ◽  
Vol 234 (3) ◽  
pp. 306-313 ◽  
Author(s):  
Lei Lv ◽  
Guang-Yan Yan ◽  
Ying-Lan Zhao ◽  
Xiao-Juan He ◽  
Xing Jiang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Local Lymph Node
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