scholarly journals Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance

2020 ◽  
Vol 8 (6) ◽  
pp. 310-310
Author(s):  
Bao Chen Yang ◽  
Shang Ying Wu ◽  
Po Sing Leung
Keyword(s):  
Pancreatic Islet ◽  
Alcohol Ingestion ◽  
Islet Dysfunction

scholarly journals Loss of ARNT/HIF1β Mediates Altered Gene Expression and Pancreatic-Islet Dysfunction in Human Type 2 Diabetes

Cell ◽  
2005 ◽  
Vol 122 (3) ◽  
pp. 337-349 ◽  
Author(s):  
Jenny E. Gunton ◽  
Rohit N. Kulkarni ◽  
SunHee Yim ◽  
Terumasa Okada ◽  
Wayne J. Hawthorne ◽  
...  
Keyword(s):  
Gene Expression ◽  
Type 2 Diabetes ◽  
Pancreatic Islet ◽  
Altered Gene Expression ◽  
Human Type ◽  
Islet Dysfunction ◽  
Altered Gene

Mitochondria Play a Key Role in Oxidative Stress-induced Pancreatic Islet Dysfunction after Severe Burns

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Xinzhu Liu ◽  
Zhaoxing Liu ◽  
Dawei Li ◽  
Yuezeng Niu ◽  
Wen Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pancreatic Islet ◽  
Severe Burns ◽  
Islet Dysfunction

Loss of β-arrestin2 mediates pancreatic-islet dysfunction in mice

2013 ◽  
Vol 435 (3) ◽  
pp. 345-349 ◽  
Author(s):  
Mingliang Zhang ◽  
Yunxia Zhu ◽  
Kaida Mu ◽  
Ling Li ◽  
Junxi Lu ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Islet Dysfunction

scholarly journals Pericyte control of pancreatic islet blood flow impacts glucose homeostasis

2021 ◽  
Author(s):  
Alejandro Tamayo ◽  
Luciana Mateus Goncalves ◽  
Rayner Rodriguez-Diaz ◽  
Elizabeth Pereira ◽  
Melissa Canales ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pancreatic Islet ◽  
Glucose Homeostasis ◽  
Plasma Insulin ◽  
Hormone Secretion ◽  
Hormonal Responses ◽  
Glucose Levels ◽  
Islet Blood Flow ◽  
Islet Dysfunction

The pancreatic islet depends on blood supply to efficiently sense plasma glucose levels and deliver insulin and glucagon into the circulation. Long thought to be passive conduits of nutrients and hormones, islet capillaries were recently found to be densely covered with contractile pericytes, suggesting local control of blood flow. Here we determined the contribution of islet pericytes to the regulation of islet blood flow, plasma insulin and glucagon levels, and glycemia. Selective optogenetic activation of pericytes in intraocular islet grafts contracted capillaries and diminished blood flow. In awake mice, acute clamping of islet blood flow by optogenetic or pharmacological activation of pericytes disrupted hormonal responses, glycemia, and glucose tolerance. Our findings indicate that pericytes mediate vascular responses in the islet that are required for adequate hormone secretion and glucose homeostasis. Vascular deficiencies commonly seen in the islets of people with type 2 diabetes may impair regulation of islet blood flow and thus precipitate islet dysfunction.

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