scholarly journals Prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in China: logistic regression and random forest analysis

2020 ◽  
Vol 8 (5) ◽  
pp. 226-226 ◽  
Author(s):  
Xi Zhang ◽  
Zonglin Dai ◽  
Eric H. Y. Lau ◽  
Chunping Cui ◽  
He Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Logistic Regression ◽  
Random Forest ◽  
Bone Mineral ◽  
Potential Risk ◽  
Mineral Density ◽  
Bone Mineral Density Loss ◽  
Potential Risk Factors ◽  
Rheumatic Patients

scholarly journals Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

2020 ◽  
Author(s):  
Zhuoran Hu ◽  
Shuiming Xu ◽  
Qingyuan Yang ◽  
Jun Qi ◽  
He Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Young Patients ◽  
Mineral Density ◽  
Female Patients ◽  
Southern Chinese ◽  
Male Patients ◽  
Rheumatic Patients

Abstract Objectives: This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients.Method: A cross-sectional study recruits 1,398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Risk factors for bone loss in rheumatic patients are analyzed by logistic regression.Results: (1) Rheumatic patients are consisted of 40.0% rheumatoid arthritis (RA), 14.7% systemic lupus erythematosus (SLE), 14.2% osteoarthritis (OA), 9.2% ankylosing spondylosis (AS), 7.9% gout, 7.0% primary Sjogren syndrome (pSS), 3.8% systemic sclerosis (SSc), and 3.2% mixed connective tissue disease (MCTD). (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of AS (53.9%, P<0.001) and SLE (39.6%, P=0.034) patients is lower than the healthy controls (18.2%). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients with RA (P<0.001), OA (P=0.02) and SLE (P =0.011) than healthy counterparts. (4) Those with SLE, RA and AS gain the highest odd ratio of ‘score below the expected range for age’, osteopenia and osteoporosis, respectively. (5) Age, female, low BMI and hypovitaminosis D are found negatively associated with bone loss. Dyslipidemia and hyperuricemia could be protective factors.Conclusion: Young patients with AS and SLE have a significant higher occurrence of bone loss, and older patients with RA, OA and SLE had higher prevalence than healthy counterparts. SLE, RA, SSc and AS were founded significant higher risks to develop into bone loss after adjustment. Age, BMI and gender were commonly-associated with bone loss in all age-stratified rheumatic patients. These findings were not markedly different from those of previous studies.

scholarly journals Associations of Serum MicroRNA with Bone Mineral Density in Community-Dwelling Subjects: The Yakumo Study

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Hiroaki Nakashima ◽  
Kei Ando ◽  
Kazuyoshi Kobayashi ◽  
Taisuke Seki ◽  
Shinya Ishizuka ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Bone Mineral ◽  
Logistic Regression Analysis ◽  
Odds Ratio ◽  
Significant Risk ◽  
Mineral Density ◽  
Confidential Interval

Osteoporosis is a disease characterized by deterioration of bone tissue and mass, with an increasing global prevalence. Therefore, the discovery of biomarkers for osteoporosis would help to guide appropriate treatment. Circulating microRNAs (miRNAs) have become increasingly recognized as biomarkers for detecting diseases. However, few studies have investigated the association of circulating miRNA with osteoporosis in the general population. The aim of this study was to identify miRNA associated with osteoporosis in a general resident health check-up for potential use as an osteoporosis biomarker. We conducted a cross-sectional study as part of a health check-up program and recruited 352 volunteers (139 men, 213 women, mean age 64.1±9.6 years). Osteoporosis was diagnosed according to the WHO classification. Twenty-two candidate microRNAs were screened through real-time quantitative PCR, and miRNAs associated with osteoporosis were analyzed using logistic regression analysis including other risk factors. In total, 95 females and 30 males were diagnosed with osteoporosis with bone mineral density tests (BMD: T‐score<−2.5). We found that miR195 was significantly lower in females, while miR150 and miR222 were significantly higher in males. The results of the logistic regression analysis indicated that in females, higher age and lower miR195 (odds ratio: 0.45, 95% confidential interval: 0.03–0.98) were significant risk factors for lower BMD, while the presence of a smoking habit and lower miR150 (odds ratio: 1.35, 95% confidential interval: 1.02–1.79) were significant risk factors for osteoporosis. Serum levels of miR195 and miR150 are independently associated with low bone mineral density in females and males, respectively.

scholarly journals Discordance between Spinal and Hip Bone Mineral Density Values in Patients with Lumbar Scoliosis – Experience of a Single Institute

2018 ◽  
Vol 18 (2) ◽  
pp. 121-124
Author(s):  
Shamim MF Begum ◽  
Nasreen Sultana ◽  
Zeenat Jabin ◽  
Rahima Parveen ◽  
Azmal Kabir Sarker ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Bone Mineral ◽  
Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Multivariate Logistic Regression ◽  
Mineral Density ◽  
Lumbar Scoliosis

Osteoporosis and scoliosis are encountered concurrently. Scoliosis predisposes to osteoporosis but degenerative scoliosis could falsely elevate lumbar bone mineral density measurement leading to discordance. This study was conducted to determine the prevalence of discordance between lumbar spines and hip bone mineral density in patients with lumbar scoliosis and to evaluate the risk factors of discordance. The prevalence of osteoporosis and discordance was determined as major and minor discordance. Old age, age at menopause, sex and BMI were considered as possible risk factors for discordance and were used in multivariate logistic regression analysis.   Discordance between lumbar spines and hip was found in 55 (78.6 %) patients and among them major and minor discordance of T-scores were seen in 18 (25.7%) and 37 (52.9%) respectively. Concordance of T scores was seen in 15 (21.4%). In multivariate logistic regression analysis female sex, age older than 60 years and BMI less than 30 kg/m2 was identified as risk factors for T-score discordance.In lumbar scoliosis the overestimation of lumbar spine may lead to diagnostic dilemma, whereas hip DEXA appears to be more reliable in these cases. In such cases it is in the jurisdiction of the physician to look for possible underlying causes of discordance of T score.Bangladesh J. Nuclear Med. 18(2): 121-124, July 2015

scholarly journals Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

2020 ◽  
Author(s):  
Zhuoran Hu ◽  
Shuiming Xu ◽  
Qingyuan Yang ◽  
Jun Qi ◽  
He Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Lupus Erythematosus ◽  
Hypovitaminosis D ◽  
Mineral Density ◽  
Systemic Lupus ◽  
Male Patients ◽  
Rheumatic Patients

Abstract Objectives: This study was to explore the prevalence of different severities of bone loss and the potential risk factors in rheumatic patients. Method: An analytical cross-sectional study design was performed. For the present study, 1,398 rheumatic patients and 302 healthy subjects were recruited and further accepted for data collection and blood and bone mineral density tests. Risk factors for bone loss in rheumatic patients were further analyzed by using multivariate logistic regression analysis. Results: (1) Rheumatic patients in this study are consisted of 40.0% rheumatoid arthritis, 14.7% systemic lupus erythematosus, 14.2% osteoarthritis, 9.2% ankylosing spondylosis, 7.9% gout, 7.0% primary Sjogren syndrome, 3.8% systemic sclerosis, and 3.2% mixed connective tissue disease. (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of patients is lower than the healthy persons with the same gender and age (34.3% vs 18.2%， P =0.045). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients than healthy counterparts (92.7% vs 87.2%, P =0.017). (4) Regression analysis indicated that compared with a healthy population, those with systemic lupus erythematosus, rheumatoid arthritis and ankylosing spondylosis gained the highest odd ratio of ‘score below the expected range for age’, osteopenia and osteoporosis, respectively. (5) Hypovitaminosis D, ‘CRP elevated’ was commonly-associated with impaired bone mineral density in all rheumatic patients. Conclusion: Bone loss commonly occurs at any age in the setting of rheumatic diseases. Hypovitaminosis D, elevated CRP was probably commonly-associated with impaired BMD in all age groups of rheumatic patients.

Risk factors for bone mineral density loss in pediatric renal transplant patients

2000 ◽  
Vol 4 (2) ◽  
pp. 146-150 ◽  
Author(s):  
Eileen N. Ellis ◽  
Donna Floyd-gimon ◽  
Phillip Berry ◽  
Thomas Wells ◽  
Joanna Seibert ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Renal Transplant ◽  
Bone Mineral ◽  
Mineral Density ◽  
Bone Mineral Density Loss ◽  
Transplant Patients ◽  
Pediatric Renal Transplant ◽  
Renal Transplant Patients

Bone mineral density and associated risk factors: in healthy Indian population

2016 ◽  
Author(s):  
Swati Waghdhare ◽  
Neelam Kaushal ◽  
Rajinder K Jalali ◽  
Divya Vohora ◽  
Sujeet Jha
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Indian Population ◽  
Mineral Density ◽  
Associated Risk Factors
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