Resection of an Ewing’s sarcoma of the right distal humerus

ASVIDE ◽  
2019 ◽  
Vol 6 ◽  
pp. 65-65
Author(s):  
Marco Innocenti ◽  
Elena Lucattelli ◽  
Mattia Brogi ◽  
Francesca Totti ◽  
Domenico Andrea Campanacci
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Distal Humerus ◽  
The Right

scholarly journals A case of Extraskeletal Ewing's sarcoma arising from the right chest wall.

1999 ◽  
Vol 38 (6) ◽  
pp. 613-614 ◽  
Author(s):  
Hirofumi SAKURAI ◽  
Akiko KOBAYASHI ◽  
Tetsurou ICHIKAWA ◽  
Hiroshi HASHIMOTO
Keyword(s):  
Chest Wall ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Extraskeletal Ewing’S Sarcoma ◽  
The Right

Brain and bone scans in primary Ewing's sarcoma of the petrous bone

1976 ◽  
Vol 44 (5) ◽  
pp. 608-612 ◽  
Author(s):  
Pete M. Fitzer ◽  
William R. Steffey
Keyword(s):  
Bone Scan ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Petrous Bone ◽  
Diagnosis And Treatment ◽  
Content Type ◽  
Brain Scan ◽  
Bone Scans ◽  
The Right ◽  
Fine Print

✓ The authors present a case in which primary Ewing's sarcoma of the right petrous pyramid in a 9-year-old girl showed no uptake on a 99mTc-pertechnetate nuclide angiogram. Intense uptake was present on a 99mTc-polyphosphate bone scan, but a static brain scan was only minimally abnormal. The diagnosis and treatment of Ewing's sarcoma are reviewed.

scholarly journals Delayed Diagnosis of Ewing's Sarcoma of the Right Humerus Initially Treated as Chronic Osteomyelitis: A Case Report

2005 ◽  
Vol 13 (1) ◽  
pp. 88-92 ◽  
Author(s):  
BPB Tow ◽  
MH Tan
Keyword(s):  
Case Report ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Chronic Osteomyelitis ◽  
Delayed Diagnosis ◽  
Delay In Diagnosis ◽  
Limited Stage ◽  
History Of ◽  
Anti Inflammatory ◽  
The Right

We report a case of limited stage Ewing's sarcoma which was initially treated as chronic osteomyelitis for 3 years. A 24-year-old man presented with a one-week history of pain in the right arm and fever, with histology suggestive of osteomyelitis of the affected humerus. He developed multiple relapses of pain and fever; each episode responded to antibiotic treatment. A second biopsy was performed 3 years later and confirmed a diagnosis of Ewing's sarcoma. Despite a 3-year delay in diagnosis, the disease remained localised. This case report highlights an atypical facet of the natural history of Ewing's sarcoma: a response to antibiotic and anti-inflammatory agents, and the limited stage of the disease despite a misdiagnosis of 3 years. This suggests the possibility that anti-inflammatory agents exert an inhibitory effect on the tumour growth. We also highlight the newer histologic and immunologic staining used in the diagnosis of Ewing's sarcoma.

scholarly journals Ewing's sarcoma with distant metastasis: A brief note on management and emerging therapies

2019 ◽  
Vol 9 (3) ◽  
Author(s):  
Girish Gulab Meshram ◽  
Neeraj Kaur ◽  
Kanwaljeet Singh Hura
Keyword(s):  
High Risk ◽  
Distant Metastasis ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Molecular Targets ◽  
Chemotherapeutic Agents ◽  
Young Population ◽  
Emerging Therapies ◽  
The Right ◽  
High Risk Case

Ewing’s sarcoma is an aggressive fatal malignancy of bones and soft-tissue. It predominantly affects the young population, with a worldwide incidence of three cases per million. The pelvis, extremities, and ribs are the most common sites. We present a case of massive Ewing’s sarcoma of the right femur with metastasis to bones and lungs. The patient was treated with chemotherapy. However, he succumbed to his illness before completion of therapy. In conclusion, Ewing’s sarcoma with distant metastasis is a high risk case with poor prognosis. Integrating novel molecular targets with conventional chemotherapeutic agents holds a promise for high-risk Ewing’s sarcoma patients.

Electron Microscopy of Extraskeletal Neoplasm Resembling Ewing's Sarcoma

1976 ◽  
Vol 34 ◽  
pp. 236-237
Author(s):  
B. N. SUD
Keyword(s):  
Electron Microscopy ◽  
Soft Tissues ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Viable Cells ◽  
Necrotic Tumor ◽  
Poorly Differentiated ◽  
Children And Young Adults ◽  
The Right ◽  
Paravertebral Region

Review of 39 cases of sarcomas involving soft tissues, especially of the lower extremity and paravertebral region of children and young adults, disclosed a uniform histologic picture that was indistinguishable from that of Ewing's sarcoma of bone (1). Biopsy of a soft tissue tumor of the right thigh of a ten year old boy was studied by light microscopy and diagnosed as poorly differentiated sarcoma, probably extra skeletal Ewing's sarcoma (2). A portion of the biopsy was processed for electron microscopy to elucidate the ultrastructural pathology.The specimen revealed a neoplasm, consisting of sheets of viable as well as necrotic tumor cells. The viable cells had a single large rounded, oval or kidney- shaped nucleus with one or more dense nucleoli and chromatin with occasional clumping along the periphery and also in the interior.

scholarly journals PRIMARY EWING'S SARCOMA OF THE NASAL CAVITY IN PEDIATRIC PRACTICE

2021 ◽  
Vol 06 (01) ◽  
pp. 102-103
Author(s):  
Bekisheva Aigul Bekisheva Aigul ◽  
Makhneva Anna Makhneva Anna ◽  
Bulegenova Minira Bulegenova Minira ◽  
Abyov Galyjan Abyov Galyjan ◽  
Remkulova Mahabbat Remkulova Mahabbat
Keyword(s):  
Differential Diagnosis ◽  
Nasal Cavity ◽  
Tumor Cells ◽  
Paranasal Sinuses ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Diagnostic Methods ◽  
Pelvic Bone ◽  
Radiological Features ◽  
The Right

Introduction: Ewing's sarcoma (ES) is an aggressive tumor occuring more frequently in childhood and adolescence, mainly observed during the first three decades of life. Microscopically consists of small round cells, with a high nuclear cytoplasmic index, originating from primitive neuroectodermal cells. Most often such tumor occurs in early childhood or adolescence. [1] Ewing's sarcoma refers to tumors of the bone tissue : the limbs, ribs, and pelvic bone, but also it may occur in soft tissues, which means any localization in the human body. Among extra-skeletal localities, ES rarely occurs in the head and neck (2-3% of all ES) and extremely rare in the nasal cavity or paranasal sinuses [1,2,3]. Diagnosis the primary of ES nasal localization is complex and mainly depends on histopathological research, as visual diagnostic methods (x-ray, CT, MRI) do not identify the type of tumor. MRI examination of tumors of such localization may suggest a malignant nature, so further differential diagnosis should exclude the following: malignant lymphoma, rhabdomyosarcoma, moderately differentiated carcinomas, and ES. These tumors have common radiological features, so they require additional research [4,5]. From abovementioned, the following clinical case of primary Ewing's sarcoma in the nasal cavity in a 14-year-old girl seemed to be interesting . The patient complained on the difficulty of breathing, swelling in the right half of the nose wing. MRI showed a large neopasm of the facial skull on the right (pterygoid and subterranean fossa, right half of the nose, nasopharynx, latticed bone and paranasal sinuses). Histological examination of the samples revealed a solid neoplastic tissue consisting of monomorphic small circular or oval cells with a high nuclear-cytoplasmic index. Some exapnsion of the tumor cells around the vessels was observed, while part of epithelial lining and glandular structures were preserved in the same places. Foci of necrosis and extensive hemorrhages were visualized. The immunohistochemical study with the CD99 antibody showed a total positive membrane reaction with the closure of the stained membranes ( with the presence of membranes ring staining ). The reaction with anti Fli1 revealed total nuclear staining of tumor cells, except for the stromal cells. Thus: as primary Ewing's sarcoma affects the sinus tract very rarely, diagnosis of the tumor in this location is difficult. MRI and other visual methods in these cases are not informative, because a number of tumors have common radiological features, that make the differential diagnosis very difficult. In this regard, the pathomorphological study including immunohistochemical research is the main method of diagnosing ES.

Solitary extra-skeletal sinonasal metastasis from a primary skeletal Ewing's sarcoma

2011 ◽  
Vol 125 (8) ◽  
pp. 861-864 ◽  
Author(s):  
S M Hayes ◽  
T N Jani ◽  
S M Rahman ◽  
S Jogai ◽  
P G Harries ◽  
...  
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
In Situ Hybridisation ◽  
Immunohistochemical Analysis ◽  
Skeletal Metastasis ◽  
Malignant Tumour ◽  
Positive Staining ◽  
Transnasal Approach ◽  
Atypical Cells ◽  
The Right

AbstractIntroduction:Ewing's sarcoma is a rare, malignant tumour predominantly affecting young adolescent males. We describe a unique case of an isolated extra-skeletal metastasis from a skeletal Ewing's sarcoma primary, arising in the right sinonasal cavity of a young man who presented with severe epistaxis and periorbital cellulitis.Results:Histologically, the lesion comprised closely packed, slightly diffuse, atypical cells with round, hyperchromatic nuclei, scant cytoplasm and occasional mitotic figures, arranged in a sheet-like pattern. Immunohistochemical analysis showed positive staining only for cluster of differentiation 99 glycoprotein. Fluorescent in situ hybridisation identified the Ewing's sarcoma gene, confirming the diagnosis.Management:Complete surgical resection was achieved via a minimally invasive endoscopic transnasal approach; post-operative radiotherapy. Ten months post-operatively, there were no endoscopic or radiological signs of disease.Conclusion:Metastatic Ewing's sarcoma within the head and neck is incredibly rare and can pose significant diagnostic and therapeutic challenges. An awareness of different clinical presentations and distinct histopathological features is important to enable early diagnosis. This case illustrates one potential management strategy, and reinforces the evolving role of endoscopic transnasal approaches in managing sinonasal cavity and anterior skull base tumours.

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