CT images showing multiple liver metastases pre-treatment on left hand panel and resolution of liver disease on right hand panel 4 weeks after pelvic radiation therapy and chemotherapy

ASVIDE ◽  
2017 ◽  
Vol 4 ◽  
pp. 514-514
Author(s):  
Moss Bruton Joe ◽  
Julian J. Lum ◽  
Peter H. Watson ◽  
R. Petter Tonseth ◽  
John Paul McGhie ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Liver Disease ◽  
Liver Metastases ◽  
Ct Images ◽  
Hand Panel ◽  
Pelvic Radiation ◽  
Left Hand ◽  
Left Hand Panel ◽  
Pre Treatment ◽  
Multiple Liver Metastases

scholarly journals Simple calculation using anatomical features on pre-treatment verification CT for bladder volume estimation during radiation therapy for rectal cancer

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Nalee Kim ◽  
Hong In Yoon ◽  
Jin Sung Kim ◽  
Woong Sub Koom ◽  
Jee Suk Chang ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cone Beam Ct ◽  
Ct Images ◽  
Volume Estimation ◽  
Bladder Volume ◽  
Cone Beam ◽  
Anatomical Features ◽  
Treatment Verification ◽  
Pre Treatment ◽  
Bladder Scanner

Abstract Background Despite detailed instruction for full bladder, patients are unable to maintain consistent bladder filling during a 5-week pelvic radiation therapy (RT) course. We investigated the best bladder volume estimation procedure for verifying consistent bladder volume. Methods We reviewed 462 patients who underwent pelvic RT. Biofeedback using a bladder scanner was conducted before simulation and during treatment. Exact bladder volume was calculated by bladder inner wall contour based on CT images (Vctsim). Bladder volume was estimated either by bladder scanner (Vscan) or anatomical features from the presacral promontory to the bladder base and dome in the sagittal plane of CT (Vratio). The feasibility of Vratio was validated using daily megavoltage or kV cone-beam CT before treatment. Results Mean Vctsim was 335.6 ± 147.5 cc. Despite a positive correlation between Vctsim and Vscan (R2 = 0.278) and between Vctsim and Vratio (R2 = 0.424), Vratio yielded more consistent results than Vscan, with a mean percentage error of 26.3 (SD 19.6, p < 0.001). The correlation between Vratio and Vctsim was stronger than that between Vscan and Vctsim (Z-score: − 7.782, p < 0.001). An accuracy of Vratio was consistent in megavoltage or kV cone-beam CT during treatment. In a representative case, we can dichotomize for clinical scenarios with or without bowel displacement, using a ratio of 0.8 resulting in significant changes in bowel volume exposed to low radiation doses. Conclusions Bladder volume estimation using personalized anatomical features based on pre-treatment verification CT images was useful and more accurate than physician-dependent bladder scanners. Trial registration Retrospectively registered.

Pelvic radiation therapy combined with hepatic artery chemotherapy for resected rectal carcinoma with liver metastases

1996 ◽  
Vol 34 (1) ◽  
pp. 155-159
Author(s):  
John M. Robertson ◽  
Christine Cha ◽  
James C. Andrews ◽  
William D. Ensminger ◽  
Theodore S. Lawrence
Keyword(s):  
Radiation Therapy ◽  
Liver Metastases ◽  
Hepatic Artery ◽  
Rectal Carcinoma ◽  
Pelvic Radiation ◽  
Hepatic Artery Chemotherapy

scholarly journals Benefit of replanning in MR-guided online adaptive radiation therapy in the treatment of liver metastasis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Michael Mayinger ◽  
Roman Ludwig ◽  
Sebastian M. Christ ◽  
Riccardo Dal Bello ◽  
Alex Ryu ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Liver Metastases ◽  
Organs At Risk ◽  
Treatment Plan ◽  
Target Volume ◽  
Target Coverage ◽  
Adaptive Replanning ◽  
Pre Treatment ◽  
Grade 3 ◽  
Dosimetric Analysis

Abstract Purpose To assess the effects of daily adaptive MR-guided replanning in stereotactic body radiation therapy (SBRT) of liver metastases based on a patient individual longitudinal dosimetric analysis. Methods Fifteen patients assigned to SBRT for oligometastatic liver metastases underwent daily MR-guided target localization and on-table treatment plan re-optimization. Gross tumor volume (GTV) and organs at risk (OARs) were adapted to the anatomy-of-the-day. A reoptimized plan (RP) and a rigidly shifted baseline plan (sBP) without re-optimization were generated for each fraction. After extraction of DVH parameters for GTV, planning target volume (PTV), and OARs (stomach, duodenum, bowel, liver, heart) plans were compared on a per-patient basis. Results Median pre-treatment GTV and PTV were 14.9 cc (interquartile range (IQR): 7.7–32.9) and 62.7 cc (IQR: 42.4–105.5) respectively. SBRT with RP improved PTV coverage (V100%) for 47/75 of the fractions and reduced doses to the most proximal OARs (D1cc, Dmean) in 33/75 fractions compared to sBP. RP significantly improved PTV coverage (V100%) for metastases within close proximity to an OAR by 4.0% (≤ 0.2 cm distance from the edge of the PTV to the edge of the OAR; n = 7; p = 0.01), but only by 0.2% for metastases farther away from OAR (> 2 cm distance; n = 7; p = 0.37). No acute grade 3 treatment-related toxicities were observed. Conclusions MR-guided online replanning SBRT improved target coverage and OAR sparing for liver metastases with a distance from the edge of the PTV to the nearest luminal OAR < 2 cm. Only marginal improvements in target coverage were observed for target distant to critical OARs, indicating that these patients do not benefit from daily adaptive replanning.

scholarly journals A Concise Review of Pelvic Radiation Therapy (RT) for Rectal Cancer with Synchronous Liver Metastases

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Omer Sager ◽  
Ferrat Dincoglan ◽  
Selcuk Demiral ◽  
Bora Uysal ◽  
Hakan Gamsiz ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Radiation Therapy ◽  
Liver Metastases ◽  
Stage Iv ◽  
Local Tumor Control ◽  
Health Concern ◽  
Treatment Modalities ◽  
Tumor Control ◽  
Pelvic Radiation ◽  
Synchronous Liver Metastases

Background and Objective. Colorectal cancer is a major health concern as a very common cancer and a leading cause of cancer-related mortality worldwide. The liver is a very common site of metastatic spread for colorectal cancers, and, while nearly half of the patients develop metastases during the course of their disease, synchronous liver metastases are detected in 15% to 25% of cases. There is no standardized treatment in this setting and no consensus exists on optimal sequencing of multimodality management for rectal cancer with synchronous liver metastases. Methods. Herein, we review the use of pelvic radiation therapy (RT) as part of potentially curative or palliative management of rectal cancer with synchronous liver metastases. Results. There is accumulating evidence on the utility of pelvic RT for facilitating subsequent surgery, improving local tumor control, and achieving palliation of symptoms in patients with stage IV rectal cancer. Introduction of superior imaging capabilities and contemporary RT approaches such as Intensity Modulated Radiation Therapy (IMRT) and Image Guided Radiation Therapy (IGRT) offer improved precision and toxicity profile of radiation delivery in the modern era. Conclusion. Even in the setting of stage IV rectal cancer with synchronous liver metastases, there may be potential for extended survival and cure by aggressive management of primary tumor and metastases in selected patients. Despite lack of consensus on sequencing of treatment modalities, pelvic RT may serve as a critical component of multidisciplinary management. Resectability of primary rectal tumor and liver metastases, patient preferences, comorbidities, symptomatology, and logistical issues should be thoroughly considered in decision making for optimal management of patients.

De Meester van de Magdalena-legende en de diptiek van Willem van Bibaut

1994 ◽  
Vol 108 (2) ◽  
pp. 73-78 ◽  
Author(s):  
Marc Rudolf De Vrij
Keyword(s):  
Left Breast ◽  
Hand Panel ◽  
Left Hand ◽  
Left Hand Panel ◽  
15Th Century ◽  
Right Hand ◽  
The Right

AbstractWithin the range of works attributed to the Master of the Magdalen Legend are a number of Madonnas generally considered to date back to the last decade of the 15th century. All of these pictures are comparatively small and show a rather chubby type of Madonna with the Child slightly out of proportion. The golden backgrounds are punctuated. All these pictures are by the same hand, and are considered to date from the earliest period of the artist's activity. One of these paintings, now in the Mayer-Van den Bergh Museum in Antwerp, shows the Madonna holding the Child at her left breast. There is a second version of this painting on the left-hand panel of a diptych formerly in the Wetzlar collection in Amsterdam. The right-hand panel bears the portrait of a Carthusian monk, and is inscribed Guilelmus bibaucis primas tot [ius] Ordinis Carthusiemum. 1523.. The sitter has been identified as Willem of Bibaut (1484 1535), who became abbot of the Grand Chartreuse monastery in Grenoble in 1521. The portrait was probably painted to commemorate that event. Given that the stylistically very different paintings belonging to the Magdalen altarpiece which gave the artist his name date from the same period, the Madonnas can no longer be regarded as early paintings by the Master of the Magdalen Legend. Apparently they are the work of another artist.

scholarly journals Complete Response of Liver Metastasis of Gastric Cancer Treated by S-1 Chemoradiotherapy: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Tomonori Miyazawa ◽  
Kazuyu Ebe ◽  
Norihiko Koide ◽  
Nobuhiro Fujita
Keyword(s):  
Gastric Cancer ◽  
Computed Tomography ◽  
Radiation Therapy ◽  
Case Report ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Distal Gastrectomy ◽  
Complete Response ◽  
Complete Disappearance ◽  
Multiple Liver Metastases

This paper presents a case of suspected liver metastasis of gastric cancer and a virtual complete response to S-1 chemoradiotherapy. A 69-year-old man underwent distal gastrectomy for gastric cancer in 2008. Multiple liver metastases occurred in 2009. He underwent 15 courses of S-1 therapy and radiation therapy (37.5 Gy). Abdominal computed tomography showed virtual complete disappearance of liver metastasis after chemoradiotherapy. Hence, this case was interpreted as a complete response. No sign of recurrence was noted 18 months after complete response was confirmed. S-1 chemoradiotherapy is likely to be effective in treating patients with liver metastases of gastric cancer.

scholarly journals Benefit of Replanning in MR-guided Online Adaptive Radiation Therapy in the Treatment of Liver Metastasis

2021 ◽  
Author(s):  
Michael Mayinger ◽  
Roman Ludwig ◽  
Sebastian M. Christ ◽  
Riccardo Dal Bello ◽  
Alex Ryu ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Liver Metastases ◽  
Organs At Risk ◽  
Treatment Plan ◽  
Target Volume ◽  
Target Coverage ◽  
Adaptive Replanning ◽  
Pre Treatment ◽  
Grade 3 ◽  
Dosimetric Analysis

Abstract Purpose: To assess the effects of daily adaptive MR-guided replanning in stereotactic body radiation therapy (SBRT) of liver metastases based on a patient individual longitudinal dosimetric analysis. Methods: Fifteen patients assigned to SBRT for oligometastatic liver metastases underwent daily MR-guided target localization and on-table treatment plan re-optimization. Gross tumor volume (GTV) and organs at risk (OARs) were adapted to the anatomy-of-the-day. A reoptimized plan (RP) and a rigidly shifted baseline plan (sBP) without re-optimization were generated for each fraction. After extraction of DVH parameters for GTV, planning target volume (PTV), and OARs (stomach, duodenum, bowel, liver, heart) plans were compared on a per-patient basis.Results: Median pre-treatment GTV and PTV were 14.9 cc (interquartile range (IQR): 7.7 – 32.85) and 62.7 cc (IQR: 42.4 – 105.5) respectively. SBRT with RP improved PTV coverage (V100%) for 47/75 of the fractions and reduced doses to the most proximal OARs (D1cc, Dmean) in 33/75 fractions compared to sBP. RP significantly improved PTV coverage (V100%) for metastases within close proximity to an OAR by 4.0 % (≤ 0.2 cm distance; n = 7; p = 0.01), but only by 0.2% for metastases farther away from OAR (> 2 cm distance; n = 7; p = 0.37). No acute grade 3 treatment-related toxicities were observed.Conclusion: MR-guided online replanning SBRT improved target coverage and OAR sparing for liver metastases with a distance of more < 2 cm to the nearest luminal OAR. Only marginal improvements in target coverage were observed for target distant to critical OARs, indicating that these patients do not benefit from daily adaptive replanning.

The evolving role of pelvic radiation therapy

2003 ◽  
Vol 13 (2) ◽  
pp. 109-120 ◽  
Author(s):  
Terence Roberts ◽  
Mack Roach
Keyword(s):  
Radiation Therapy ◽  
Pelvic Radiation
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