Resection of a pulmonary bulla with a rim of normal lung tissue using an endoscopic stapler

ASVIDE ◽  
2017 ◽  
Vol 4 ◽  
pp. 459-459
Author(s):  
Pankaj Kumar Garg ◽  
Sai Yendamuri
Keyword(s):  
Lung Tissue ◽  
Normal Lung Tissue ◽  
Normal Lung ◽  
Endoscopic Stapler

scholarly journals Metformin Protects against Radiation-Induced Acute Effects by Limiting Senescence of Bronchial-Epithelial Cells

2021 ◽  
Vol 22 (13) ◽  
pp. 7064
Author(s):  
Christine Hansel ◽  
Samantha Barr ◽  
Alina V. Schemann ◽  
Kirsten Lauber ◽  
Julia Hess ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Lung Tissue ◽  
Cellular Stress ◽  
Lung Epithelial Cells ◽  
Normal Lung Tissue ◽  
Normal Lung ◽  
Metformin Treatment ◽  
Acute Effects ◽  
Lung Epithelial ◽  
Radiation Induced

Radiation-induced damage to normal lung parenchyma remains a dose-limiting factor in thorax-associated radiotherapy (RT). Severe early and late complications with lungs can increase the risk of morbidity in cancer patients after RT. Herein, senescence of lung epithelial cells following RT-induced cellular stress, or more precisely the respective altered secretory profile, the senescence-associated secretory phenotype (SASP), was suggested as a central process for the initiation and progression of pneumonitis and pulmonary fibrosis. We previously reported that abrogation of certain aspects of the secretome of senescent lung cells, in particular, signaling inhibition of the SASP-factor Ccl2/Mcp1 mediated radioprotection especially by limiting endothelial dysfunction. Here, we investigated the therapeutic potential of a combined metformin treatment to protect normal lung tissue from RT-induced senescence and associated lung injury using a preclinical mouse model of radiation-induced pneumopathy. Metformin treatment efficiently limited RT-induced senescence and SASP expression levels, thereby limiting vascular dysfunctions, namely increased vascular permeability associated with increased extravasation of circulating immune and tumor cells early after irradiation (acute effects). Complementary in vitro studies using normal lung epithelial cell lines confirmed the senescence-limiting effect of metformin following RT finally resulting in radioprotection, while fostering RT-induced cellular stress of cultured malignant epithelial cells accounting for radiosensitization. The radioprotective action of metformin for normal lung tissue without simultaneous protection or preferable radiosensitization of tumor tissue might increase tumor control probabilities and survival because higher radiation doses could be used.

scholarly journals Normal lung tissue complication probability in MR-Linac and conventional radiotherapy

2020 ◽  
Vol 25 (6) ◽  
pp. 961-968
Author(s):  
Somayeh Gholami ◽  
Francesco Longo ◽  
Sara Shahzadeh ◽  
Hassan Ali Nedaie ◽  
Ryan Sharp ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Normal Lung Tissue ◽  
Normal Lung ◽  
Conventional Radiotherapy

EP-1149: Influence of histology and smoking status on PD-L1, PD1 and CTLA4 expression of tumor vs. normal lung tissue in NSCLC

2014 ◽  
Vol 111 ◽  
pp. S37
Author(s):  
K. Reynders ◽  
E. Wauters ◽  
J. Vansteenkiste ◽  
H. Decaluwé ◽  
K. Nackaerts ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Smoking Status ◽  
Normal Lung Tissue ◽  
Normal Lung

AbnormalFHIT transcripts found in both lung cancer and normal lung tissue

1999 ◽  
Vol 24 (2) ◽  
pp. 105-111 ◽  
Author(s):  
Yoshio Tokuchi ◽  
Yasuhito Kobayashi ◽  
Shin-ichi Hayashi ◽  
Moriaki Hayashi ◽  
Keiji Tanimoto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Tissue ◽  
Normal Lung Tissue ◽  
Normal Lung

Abstract 530: Contribution of fibroblasts isolated from primary lung cancers and normal lung tissue to tumor growth

2011 ◽  
Author(s):  
Francesca Andriani ◽  
Giulia Bertolini ◽  
Roberto Caserini ◽  
Sara Bursomanno ◽  
Patrizia Gasparini ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Tissue ◽  
Normal Lung Tissue ◽  
Normal Lung ◽  
Lung Cancers
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