scholarly journals The efficacy and safety of capecitabine-based versus S-1-based chemotherapy for metastatic or recurrent gastric cancer: a systematic review and meta-analysis of clinical randomized trials

2020 ◽  
Vol 9 (3) ◽  
pp. 883-894
Author(s):  
Zhijun Feng ◽  
Peijing Yan ◽  
Xiaofeng Hou ◽  
Jie Feng ◽  
Xiaodong He ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Randomized Trials ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Recurrent Gastric Cancer

scholarly journals The efficacy and safety of S-1-based regimens in the first-line treatment of advanced gastric cancer: a systematic review and meta-analysis

2016 ◽  
Vol 19 (3) ◽  
pp. 696-712 ◽  
Author(s):  
Emil ter Veer ◽  
Nadia Haj Mohammad ◽  
Paul Lodder ◽  
Lok Lam Ngai ◽  
Mary Samaan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Advanced Gastric Cancer ◽  
Meta Analysis ◽  
Line Treatment ◽  
Efficacy And Safety ◽  
First Line ◽  
First Line Treatment

scholarly journals Efficacy and Safety of Brucea javanica Oil Emulsion Injection in the Treatment of Gastric Cancer: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Xinmiao Wang ◽  
Heping Wang ◽  
Luchang Cao ◽  
Jingyuan Wu ◽  
Taicheng Lu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Conventional Therapy ◽  
Meta Analysis ◽  
Performance Status ◽  
Biomedical Literature ◽  
Therapeutic Effects ◽  
Efficacy And Safety ◽  
Oil Emulsion ◽  
Brucea Javanica

Background: Gastric cancer (GC) is one of the most common digestive tract cancers and ranks fifth in the incidence of malignant tumors worldwide. Brucea javanica oil emulsion injection (BJOEI), a Chinese patent medicine extracted from Brucea javanica (Yadanzi in Chinese Pinyin), is widely used as an adjuvant treatment for GC in China. This systematic review and meta-analysis aimed to evaluate the available data on the efficacy and safety of BJOEI in the treatment of GC and assess the quality of the synthesized evidence.Methods: A comprehensive search was performed on PubMed, EMBASE, CENTRAL, Web of Science, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang database and Chinese Scientific Journals Database (VIP database), and other potential resources, such as the Chinese Clinical Trial Registry (ChiCTR) and ClinicalTrials.gov from their inception to July 31, 2021. Randomized controlled trials (RCTs) comparing the therapeutic effects of BJOEI combined with conventional therapy to those of conventional therapy alone were included. We used RevMan 5.3 for data analysis and quality evaluation of the included studies and assessed the evidence quality based on the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria.Results: Eighteen RCTs involving 1,210 patients were included, and the meta-analysis results demonstrated that compared with the control group (conventional therapy), the experimental group (BJOEI combined with conventional therapy) showed a significantly improved overall response rate (ORR) (risk ratio [RR] = 1.52, 95% CI: 1.36–1.69, P < 0.00001), clinical benefit rate (CBR) (RR = 1.17, 95% CI: 1.11–1.23, P < 0.00001), performance status (RR = 1.72, 95% CI: 1.46–2.01, P < 0.00001), and reduced incidence of the following adverse drug reactions (ADRs): neutropenia, leukopenia, nausea and vomiting, diarrhea, liver damage, hand-foot syndrome, and peripheral sensory nerve toxicity. Subgroup analysis showed that the BJOEI intervention could significantly improve the ORR and CBR in patients with GC when combined with FOLFOX4, XELOX, and other chemotherapeutics.Conclusion: The evidence presented in this study supports the fact that BJOEI combined with conventional chemotherapy provides a statistically significant and clinically important effect in the improvement of ORR, CBR, performance status, and ADR reduction in patients with GC. To further support this conclusion, more rigorously designed, large-scale, and multicenter RCTs are needed in the future.

scholarly journals 870 The Efficacy and Safety of Endoscopic Submucosal Dissection for Early Gastric Cancer in Patients With Cirrhosis: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 114 (1) ◽  
pp. S504-S505
Author(s):  
Passisd Laoveeravat ◽  
Abhilash Perisetti ◽  
Wasawat Vutthikraivit ◽  
Mauricio Garcia-Saenz-de-Sicilia ◽  
Shashank Garg ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Submucosal Dissection
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