scholarly journals Changes in laser-evoked potentials during hypnotic analgesia for chronic pain: a pilot study

2018 ◽  
Vol 7 (1) ◽  
pp. 7-16 ◽  
Author(s):  
Giovanna Squintani ◽  
Maria P. Brugnoli ◽  
Emanuela Pasin ◽  
Alessia Segatti ◽  
Elisa Concon ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pilot Study ◽  
Evoked Potentials ◽  
Laser Evoked Potentials ◽  
Hypnotic Analgesia

70. Laser-evoked potentials (LEPs) in chronic pain conditions during hypnotic analgesia

2017 ◽  
Vol 128 (12) ◽  
pp. e432
Author(s):  
A. Matinella ◽  
M.P. Brugnoli ◽  
E. Pasin ◽  
A. Segatti ◽  
E. Concon ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Evoked Potentials ◽  
Laser Evoked Potentials ◽  
Hypnotic Analgesia ◽  
Chronic Pain Conditions

Focal Mechanical Vibration Does not Change Laser-Pain Perception and Laser-Evoked Potentials: A Pilot Study

Pain Practice ◽  
2016 ◽  
Vol 17 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Costanza Pazzaglia ◽  
Filippo Camerota ◽  
Claudia Celletti ◽  
Ileana Minciotti ◽  
Elisa Testani ◽  
...  
Keyword(s):  
Pilot Study ◽  
Evoked Potentials ◽  
Pain Perception ◽  
Mechanical Vibration ◽  
Laser Evoked Potentials

Conditioned pain modulation affects the N2/P2 complex but not the N1 wave: A pilot study with laser‐evoked potentials

2020 ◽  
Author(s):  
Giovanna Squintani ◽  
Andrea Rasera ◽  
Alessia Segatti ◽  
Elisa Concon ◽  
Bruno Bonetti ◽  
...  
Keyword(s):  
Pilot Study ◽  
Evoked Potentials ◽  
Pain Modulation ◽  
Conditioned Pain Modulation ◽  
Laser Evoked Potentials ◽  
N1 Wave

Anterior insula stimulation increases pain threshold in humans: a pilot study

2021 ◽  
pp. 1-6
Author(s):  
Chang-Chia Liu ◽  
Shayan Moosa ◽  
Mark Quigg ◽  
W. Jeffrey Elias
Keyword(s):  
Chronic Pain ◽  
Evoked Potentials ◽  
Pain Threshold ◽  
The United States ◽  
Anterior Insula ◽  
Heat Pain ◽  
Laser Evoked Potentials ◽  
Intracranial Eeg ◽  
Heat Pain Threshold ◽  
Stimulation Of

OBJECTIVE Chronic pain results in an enormous societal and financial burden. Opioids are the mainstay of treatment, but opioid abuse has led to an epidemic in the United States. Nonpharmacological treatment strategies like deep brain stimulation could be applied to refractory chronic pain if safe and effective brain targets are identified. The anterior insula is a putative mediator of pain-related affective-motivational and cognitive-evaluative cerebral processing. However, the effect of anterior insula stimulation on pain perception is still unknown. Here, the authors provide behavioral and neurophysiological evidence for stimulating the anterior insula as a means of potential therapeutic intervention for patients with chronic pain. METHODS Six patients with epilepsy in whom intracerebral electrodes had been implanted for seizure localization were recruited to the study. The direct anterior insula stimulations were performed in the inpatient epilepsy monitoring unit while subjects were fully awake, comfortable, and without sedating medications. The effects of anterior insula stimulation were assessed with quantitative sensory testing for heat pain threshold, nociceptive-specific cutaneous laser-evoked potentials, and intracranial electroencephalogram (EEG) recordings. Control stimulation of noninsular brain regions was performed to test stimulation specificity. Sham stimulations, in which no current was delivered, were also performed to control for potential placebo effects. The safety of these stimulations was evaluated by bedside physicians, real-time intracranial EEG monitoring, and electrocardiogram recordings. RESULTS Following anterior insula stimulations, the heat pain threshold of each patient significantly increased from baseline (p < 0.001) and correlated with stimulation intensity (regression analysis: β = 0.5712, standard error 0.070, p < 0.001). Significant changes in ongoing intracranial EEG frequency band powers (p < 0.001), reduction in laser pain intensity, and attenuated laser-evoked potentials were also observed following stimulations. Furthermore, the observed behavioral and neurophysiological effects persisted beyond the stimulations. Subjects were not aware of the stimulations, and there were no cardiovascular or untoward effects. CONCLUSIONS Additional, nonpharmacological therapies are imperative for the future management of chronic pain conditions and to mitigate the ongoing opioid crisis. This study suggests that direct stimulation of the anterior insula can safely alter cerebral pain processing in humans. Further investigation of the anterior insula as a potential target for therapeutic neuromodulation is underway.

Laser-evoked potentials to noxious stimulation during hypnotic analgesia and distraction of attention suggest different brain mechanisms of pain control

2001 ◽  
Vol 38 (5) ◽  
pp. 768-776 ◽  
Author(s):  
Marc Friederich ◽  
Ralf H. Trippe ◽  
Mustafa ozcan ◽  
Thomas Weiss ◽  
Holger Hecht ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Pain Control ◽  
Noxious Stimulation ◽  
Laser Evoked Potentials ◽  
Hypnotic Analgesia

Effect of single dose Erenumab on cortical responses evoked by cutaneous a-delta fibers: A pilot study in migraine patients

Cephalalgia ◽  
2021 ◽  
pp. 033310242199634
Author(s):  
Marina de Tommaso ◽  
Marianna Delussi ◽  
Eleonora Gentile ◽  
Katia Ricci ◽  
Silvia Giovanna Quitadamo ◽  
...  
Keyword(s):  
Single Dose ◽  
Pilot Study ◽  
Clinical Outcome ◽  
Evoked Potentials ◽  
Evoked Potential ◽  
Laser Evoked Potentials ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Cortical Responses ◽  
The Right

Background Erenumab is a monoclonal antibody against calcitonin gene-related peptide receptors, which showed efficacy in migraine attack prevention. The aims of the present pilot study were to i) evaluate the effect of single dose of Erenumab 70 mg on laser evoked potentials from trigeminal and brachial stimulation in a cohort of migraine patients; ii) correlate the neurophysiological changes with clinical outcome after 3 months’ treatment. Methods Laser evoked potentials were recorded by 61 electroencephalogram channels before (T0), 1 h (T1) and 7 days after (T2) Erenumab 70 mg injection, stimulating the left and right forehead and the right hand. Laser evoked potential control 1 h after the injection served as placebo session. Results Seventeen migraine patients were evaluated. The N1 and N2 component obtained from the right and left trigeminal stimulation diminished in amplitude at T2, compared to T0 and T1 conditions. N2 habituation reduction slightly recovered at T2. Laser evoked potential changes did not correlate with clinical improvement after 3 months of Erenumab treatment. Conclusions A single dose of Erenumab has a mild inhibitory effect on cortical responses evoked from trigeminal cutaneous a-delta fibers. Though this phenomenon was not predictive of the clinical outcome, it confirms a wide representation of calcitonin gene-related peptide receptors on trigeminal afferents.

Quantitative Sensory Testing in Animal Models of Chronic Pain: A Pilot Study

2018 ◽  
Author(s):  
B. Monteiro ◽  
M. Moreau ◽  
C. Otis ◽  
L. De Lorimier ◽  
J. Pelletier ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pilot Study ◽  
Animal Models ◽  
Quantitative Sensory Testing ◽  
Sensory Testing

Suggestion and Pain in Migraine: A Study by Laser Evoked Potentials

2012 ◽  
Vol 11 (2) ◽  
pp. 110-126 ◽  
Author(s):  
Marina de Tommaso ◽  
Antonio Federici ◽  
Giovanni Franco ◽  
Katia Ricci ◽  
Marta Lorenzo ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Laser Evoked Potentials
Sign in / Sign up

Export Citation Format

Share Document