scholarly journals AB088. P060. Safety assessment of standardized pancreatectomy in patients with solid pseudopapillary tumor and pancreatic ductal adenocarcinoma: retrospective case-control study in a single center

2018 ◽  
Vol 1 (1) ◽  
pp. AB088-AB088
Author(s):  
Peng Wang ◽  
Jishu Wei ◽  
Kai Zhang ◽  
Qiuyang Chen ◽  
Tongtai Liu ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Safety Assessment ◽  
Case Control Study ◽  
Case Control ◽  
Ductal Adenocarcinoma ◽  
Solid Pseudopapillary Tumor ◽  
Single Center ◽  
Retrospective Case ◽  
Control Study

scholarly journals Modulated Electro-Hyperthermic (mEHT) Treatment in the Therapy of Inoperable Pancreatic Cancer Patients—A Single-Center Case-Control Study

Diseases ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 81
Author(s):  
Flora Greta Petenyi ◽  
Tamas Garay ◽  
Dorottya Muhl ◽  
Blanka Izso ◽  
Adam Karaszi ◽  
...  
Keyword(s):  
Overall Survival ◽  
Case Control Study ◽  
Case Control ◽  
Ductal Adenocarcinoma ◽  
Favorable Effect ◽  
Prospective Clinical Study ◽  
Single Center ◽  
Retrospective Case ◽  
Oncological Treatment ◽  
Control Study

Our present oncological treatment arsenal has limited treatment options for pancreatic ductal adenocarcinoma (PDAC). Extended reviews have shown the benefits of hyperthermia for PDAC, supporting the perspectives with the improvements of the treatment possibilities. METHODS: A retrospective single-center case-control study was conducted with the inclusion of 78 inoperable PDAC patients. Age-, sex-, chemotherapy-, stage-, and ascites formation-matched patients were assigned to two equal groups based on the application of modulated electro-hyperthermia (mEHT). The EHY2030 mEHT device was used. RESULTS: A trend in favor of mEHT was found in overall survival (p = 0.1420). To further evaluate the potential beneficial effects of mEHT, the presence of distant metastasis or ascites in the patients’ oncological history was investigated. Of note, mEHT treatment had a favorable effect on patients’ overall survival in metastatic disease (p = 0.0154), while less abdominal fluid responded to the mEHT treatment in a more efficient way (p ≤ 0.0138). CONCLUSION: mEHT treatment was associated with improved overall survival in PDAC in our single-center retrospective case-control study. The outcome measures encourage us to design a randomized prospective clinical study to further confirm the efficiency of mEHT in this patient cohort.

scholarly journals Vitamin C and Vitamin E Mitigate the Risk of Pancreatic Ductal Adenocarcinoma from Meat-Derived Mutagen Exposure in Adults in a Case-Control Study

2019 ◽  
Vol 149 (8) ◽  
pp. 1443-1450 ◽  
Author(s):  
Donghui Li ◽  
Hongwei Tang ◽  
Peng Wei ◽  
Jiali Zheng ◽  
Carrie R Daniel ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Vitamin E ◽  
Vitamin C ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Case Control Study ◽  
Case Control ◽  
Ductal Adenocarcinoma ◽  
Dietary Vitamin ◽  
Total Vitamin ◽  
Control Study

ABSTRACT Background Previous studies have found that meat-derived mutagens increase, and vitamin C or E decrease, the risk of pancreatic cancer. Objective The aim of this study was to determine whether intake of vitamin C or E modulates the association between meat-derived mutagen exposure and risk of pancreatic cancer. Design We conducted a case-control study in 1321 patients with pathologically confirmed pancreatic ductal adenocarcinoma (PDAC) and 1061 healthy controls (aged 28–88 y). Cases and controls were frequency-matched by age, sex, and race/ethnicity. Mutagen intake was assessed using a meat preparation questionnaire. Intakes of vitamin C, E, and other dietary components were assessed via a food-frequency questionnaire in a subset of 811 cases and 818 controls. ORs and 95% CIs were estimated in multivariable-adjusted logistic regression models. Results The risk of PDAC was not associated with meat intake but was associated with consumption of well-done grilled or barbecued chicken (OR: 1.57; 95% CI: 1.18, 2.09; P = 0.001). Intake of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline was associated with increased PDAC risk (Ptrend = 0.047). Participants in the highest, as compared with the lowest, quintile of 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (PhIP) intake experienced a 38% increased risk of PDAC (95% CI: 1.00, 1.90; P = 0.048). Intakes of total vitamin C or E from food and supplements or from supplements alone were each inversely associated with PDAC risk. Stratified analyses showed differential associations for PhIP intake and PDAC risk, such that risk increased among individuals with lower intake of vitamin C or E and decreased among those with higher vitamin intake. Significant interactions of dietary vitamin C, dietary vitamin E, and total vitamin E with PhIP intake were detected (Pinteraction = 0.023, <0.001, and 0.013, respectively). Conclusions Consistent with experimental evidence, this study of 811 cases and 818 controls has shown that high intake of dietary vitamin C or E mitigates the risk of PhIP-related PDAC.

Efficacy of venlafaxine for the relief of taxane and oxaliplatin-induced acute neurotoxicity: a single-center retrospective case–control study

2015 ◽  
Vol 24 (5) ◽  
pp. 2085-2091 ◽  
Author(s):  
Tulay Kus ◽  
Gokmen Aktas ◽  
Gokay Alpak ◽  
Mehmet Emin Kalender ◽  
Alper Sevinc ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Single Center ◽  
Retrospective Case ◽  
Acute Neurotoxicity ◽  
Control Study

scholarly journals Clinical characteristics and survival analysis in critical and non-critical patients with COVID-19 in Wuhan, China: a single-center retrospective case control study

2020 ◽  
Author(s):  
Ran Tian ◽  
Wei Wu ◽  
Chunyao Wang ◽  
Haiyu Pang ◽  
Zhiyu Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Large Scale ◽  
Case Control Study ◽  
Case Control ◽  
Hospital Death ◽  
Single Center ◽  
Retrospective Case ◽  
Critical Patients ◽  
Qsofa Score ◽  
Control Study

Abstract Since the outbreak of COVID-19 in China at the end of 2019, the world has experienced a large-scale epidemic caused by the SARS-CoV-2. Epidemiological and clinical course of COVID-19 patients have been reported, but there have been few analyses about the characteristics, predictive risk factors and outcomes of critical patients. In this single-center retrospective case-control study, 90 adult inpatients hospitalized at Tongji Hospital (Wuhan, China) were included. Demographic, clinical, laboratory test and treatment data were obtained and compared between critical and non-critical patients. We found that compared with non-critical patients, the critical patients had higher SOFA score and qSOFA scores. Critical patients had lower lymphocyte and platelet count, elevated D-dimer, decreased fibrinogen, and elevated high-sensitivity C-reactive protein (hsCRP) and interleukin-6(IL-6). More critical patients received treatment including antibiotics, anticoagulation, corticosteroid and oxygen therapy than non-critical ones. Multivariable regression showed higher qSOFA score and elevation of IL-6 were related to critical patients. Antibiotic usage and anticoagulation were associated with decreased in-hospital mortality. And critical grouping contributed greatly to in-hospital death. Critical COVID-19 patients have a more severe clinical cours. qSOFA score and elevation of IL-6 are risk factors for critical condition. Non-critical grouping, positive antibiotic application and anticoagulation may be beneficial for patient survival.

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