AB079. P051. Blockage of CTR1-dependent copper absorption increases autophagy to resist apoptosis of pancreatic ductal carcinoma cells

2018 ◽  
Vol 1 (1) ◽  
pp. AB079-AB079
Author(s):  
Sheng Tai ◽  
Chun-Bo Teng
Keyword(s):  
Ductal Carcinoma ◽  
Carcinoma Cells ◽  
Pancreatic Ductal Carcinoma ◽  
Copper Absorption

Proteomic analysis of pancreatic ductal carcinoma cells treated with 5-aza-2'-deoxycytidine

2003 ◽  
Vol 24 (24) ◽  
pp. 4291-4303 ◽  
Author(s):  
Daniela Cecconi ◽  
Hubert Astner ◽  
Massimo Donadelli ◽  
Marta Palmieri ◽  
Edoardo Missiaglia ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Ductal Carcinoma ◽  
Carcinoma Cells ◽  
Pancreatic Ductal Carcinoma

scholarly journals The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells

2019 ◽  
Vol 17 (9) ◽  
pp. 1815-1827 ◽  
Author(s):  
Erika Parasido ◽  
George S. Avetian ◽  
Aisha Naeem ◽  
Garrett Graham ◽  
Michael Pishvaian ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Carcinoma Cells ◽  
Pancreatic Ductal Carcinoma ◽  
Paclitaxel Resistance

Proteomic Analysis of Pancreatic Ductal Carcinoma Cells after Combined Treatment with Gemcitabine and Trichostatin A

2005 ◽  
Vol 4 (6) ◽  
pp. 1909-1916 ◽  
Author(s):  
Daniela Cecconi ◽  
Massimo Donadelli ◽  
Aldo Scarpa ◽  
Alberto Milli ◽  
Marta Palmieri ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Ductal Carcinoma ◽  
Trichostatin A ◽  
Combined Treatment ◽  
Carcinoma Cells ◽  
Pancreatic Ductal Carcinoma

scholarly journals Ca2+ Signaling and Its Potential Targeting in Pancreatic Ductal Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3085
Author(s):  
Louay Bettaieb ◽  
Maxime Brulé ◽  
Axel Chomy ◽  
Mel Diedro ◽  
Malory Fruit ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Exocrine Pancreas ◽  
Ductal Carcinoma ◽  
Ductal Adenocarcinoma ◽  
Molecular Devices ◽  
Pancreatic Ductal Carcinoma ◽  
Aberrant Expression ◽  
Common Cause ◽  
Cancer Hallmarks ◽  
Cancer Mutations

Pancreatic cancer (PC) is a major cause of cancer-associated mortality in Western countries (and estimated to be the second cause of cancer deaths by 2030). The main form of PC is pancreatic adenocarcinoma, which is the fourth most common cause of cancer-related death, and this situation has remained virtually unchanged for several decades. Pancreatic ductal adenocarcinoma (PDAC) is inherently linked to the unique physiology and microenvironment of the exocrine pancreas, such as pH, mechanical stress, and hypoxia. Of them, calcium (Ca2+) signals, being pivotal molecular devices in sensing and integrating signals from the microenvironment, are emerging to be particularly relevant in cancer. Mutations or aberrant expression of key proteins that control Ca2+ levels can cause deregulation of Ca2+-dependent effectors that control signaling pathways determining the cells’ behavior in a way that promotes pathophysiological cancer hallmarks, such as enhanced proliferation, survival and invasion. So far, it is essentially unknown how the cancer-associated Ca2+ signaling is regulated within the characteristic landscape of PDAC. This work provides a complete overview of the Ca2+ signaling and its main players in PDAC. Special consideration is given to the Ca2+ signaling as a potential target in PDAC treatment and its role in drug resistance.

scholarly journals Anti-proliferative role of recombinant lethal toxin of Bacillus anthracis on primary mammary ductal carcinoma cells revealing its therapeutic potential

Oncotarget ◽  
2017 ◽  
Vol 8 (22) ◽  
pp. 35835-35847 ◽  
Author(s):  
Rekha Khandia ◽  
Bramhadev Pattnaik ◽  
Katherukamem Rajukumar ◽  
Atul Pateriya ◽  
Sandeep Bhatia ◽  
...  
Keyword(s):  
Bacillus Anthracis ◽  
Ductal Carcinoma ◽  
Therapeutic Potential ◽  
Lethal Toxin ◽  
Carcinoma Cells ◽  
Mammary Ductal Carcinoma

scholarly journals Efficacy of contrast-enhanced harmonic endoscopic ultrasonography in the diagnosis of pancreatic ductal carcinoma

2016 ◽  
Vol 22 (3) ◽  
pp. 198 ◽  
Author(s):  
Toshiyuki Uekitani ◽  
Seiji Kaino ◽  
Hirofumi Harima ◽  
Shigeyuki Suenaga ◽  
Manabu Sen-yo ◽  
...  
Keyword(s):  
Endoscopic Ultrasonography ◽  
Ductal Carcinoma ◽  
Pancreatic Ductal Carcinoma ◽  
Contrast Enhanced

scholarly journals The CHARACTERIZATION OF SYNERGISTIC EFFECT OF CRILIN AND NANOCURCUMIN ON TREATMENT FOR 7, 12 DIMETHYLBENZ [A] ATHRACENE (DMBA)-INDUCED BREAST CANCER MICE

2018 ◽  
Vol 34 (1) ◽  
pp. 61
Author(s):  
Gia-Buu Tran
Keyword(s):  
Breast Cancer ◽  
Synergistic Effect ◽  
Tumor Volume ◽  
Ductal Carcinoma ◽  
Inhibitory Effect ◽  
Carcinoma Cells ◽  
Herbal Remedies ◽  
Surrounding Tissue ◽  
Neoplastic Disease

Breast cancer is the neoplastic disease which is characterized by unregulated ductal and lobular hyperplasia. Some herbal remedies have been researched and proved the inhibitory effect on breast cancer such as, Crilin-extracted from Cirnum latifolum and curcumin-isolated from Cucuma longa. However, the synergistic effect of crilin and nanocurcumin have not been studied yet. In this study, we established the mouse model of breast cancer induced by DMBA and evaluated the effectiveness of combination of crilin and nanocurcumin on treatment of breast cancer. After 12 weeks, co-administration of crilin and nanocurcumin inversed alteration of body weight, the number of erythrocytes and leukocytes induced by DMBA. Furthermore, the synergistic effect of crilin and nanocucumin on reduction of tumor volume was proven. Histological analysis revealed that co-administration of crilin and nanocurcumin inhibited invasion of mammary ductal carcinoma cells into surrounding tissue, recovered lobular cells structure, and diminished leukocyte composition. Thereby, the combination of crilin and nanocurcumin recovers immune system and prevent the development of breast cancer.

scholarly journals Cutaneous Malassezia: Commensal, Pathogen, or Protector?

2021 ◽  
Vol 10 ◽  
Author(s):  
Shree Harsha Vijaya Chandra ◽  
Ramasamy Srinivas ◽  
Thomas L. Dawson ◽  
John E. Common
Keyword(s):  
Rational Design ◽  
Health Knowledge ◽  
Ductal Carcinoma ◽  
Genetic Manipulation ◽  
Seborrheic Dermatitis ◽  
Treatment Options ◽  
Pancreatic Ductal Carcinoma ◽  
Skin Microbiome ◽  
Targeted Interventions ◽  
Host Microbe Interactions

The skin microbial community is a multifunctional ecosystem aiding prevention of infections from transient pathogens, maintenance of host immune homeostasis, and skin health. A better understanding of the complex milieu of microbe-microbe and host-microbe interactions will be required to define the ecosystem’s optimal function and enable rational design of microbiome targeted interventions. Malassezia, a fungal genus currently comprising 18 species and numerous functionally distinct strains, are lipid-dependent basidiomycetous yeasts and integral components of the skin microbiome. The high proportion of Malassezia in the skin microbiome makes understanding their role in healthy and diseased skin crucial to development of functional skin health knowledge and understanding of normal, healthy skin homeostasis. Over the last decade, new tools for Malassezia culture, detection, and genetic manipulation have revealed not only the ubiquity of Malassezia on skin but new pathogenic roles in seborrheic dermatitis, psoriasis, Crohn’s disease, and pancreatic ductal carcinoma. Application of these tools continues to peel back the layers of Malassezia/skin interactions, including clear examples of pathogenicity, commensalism, and potential protective or beneficial activities creating mutualism. Our increased understanding of host- and microbe-specific interactions should lead to identification of key factors that maintain skin in a state of healthy mutualism or, in turn, initiate pathogenic changes. These approaches are leading toward development of new therapeutic targets and treatment options. This review discusses recent developments that have expanded our understanding of Malassezia’s role in the skin microbiome, with a focus on its multiple roles in health and disease as commensal, pathogen, and protector.

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