scholarly journals AB023. Ultrastable gold nanoparticles as a drug delivery system for ocular therapy

2019 ◽  
Vol 4 ◽  
pp. AB023-AB023
Author(s):  
Florence Masse ◽  
Pascale Desjardins ◽  
Mathieu Ouellette ◽  
Camille Couture ◽  
Mahmoud Mohamed Omar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ocular Therapy

scholarly journals Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery System

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 2929 ◽  
Author(s):  
Florence Masse ◽  
Pascale Desjardins ◽  
Mathieu Ouellette ◽  
Camille Couture ◽  
Mahmoud Mohamed Omar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Colloidal Stability ◽  
Corneal Epithelial ◽  
Transmission Electron ◽  
Human Corneal Epithelial Cells ◽  
The Impact ◽  
Ocular Therapy

Nanotechnologies are increasingly being developed for medical purposes. However, these nanomaterials require ultrastability for better control of their pharmacokinetics. The present study describes three types of ultrastable gold nanoparticles stabilized by thiolated polyethylene glycol groups remaining intact when subjected to some of the harshest conditions described thus far in the literature, such as autoclave sterilization, heat and freeze-drying cycles, salts exposure, and ultracentrifugation. Their stability is characterized by transmission electron microscopy, UV-visible spectroscopy, and dynamic light scattering. For comparison purposes, two conventional nanoparticle types were used to assess their colloidal stability under all conditions. The ability of ultrastable gold nanoparticles to encapsulate bimatoprost, a drug for glaucoma treatment, is demonstrated. MTS assays on human corneal epithelial cells is assessed without changing cell viability. The impact of ultrastable gold nanoparticles on wound healing dynamics is assessed on tissue engineered corneas. These results highlight the potential of ultrastable gold nanoparticles as a drug delivery system in ocular therapy.

Bovine serum albumin/gold nanoparticles as a drug delivery system for Curcumin: experimental and computational studies

2019 ◽  
Vol 38 (15) ◽  
pp. 4644-4654 ◽  
Author(s):  
Bahareh Khodashenas ◽  
Mehdi Ardjmand ◽  
Mazyar Sharifzadeh Baei ◽  
Ali Shokuhi Rad ◽  
Azim Akbarzadeh Khiyavi
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bovine Serum ◽  
Computational Studies

Thermo-responsive gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) core–corona nanoparticles as a drug delivery system

2014 ◽  
Vol 5 (18) ◽  
pp. 5289-5299 ◽  
Author(s):  
Ji Liu ◽  
Christophe Detrembleur ◽  
Marie Hurtgen ◽  
Antoine Debuigne ◽  
Marie-Claire De Pauw-Gillet ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
System P

Preparation of thermo-responsive poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) copolymer-stabilized gold nanoparticles for drug delivery.

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