scholarly journals Chemical biomarkers of exposure and early damage from potentially carcinogenic airborne pollutants

2019 ◽  
Vol 3 ◽  
pp. 5-5 ◽  
Author(s):  
Kai Luo ◽  
Irina Stepanov ◽  
Stephen S. Hecht
Keyword(s):  
Airborne Pollutants ◽  
Biomarkers Of Exposure ◽  
Chemical Biomarkers ◽  
Early Damage

APPLICATION OF THE EARLY DAMAGE DIAGNOSTICS TECHNIQUE TO EXAMINATION OF THE AVIATION PANEL

2019 ◽  
Vol 85 (6) ◽  
pp. 53-63 ◽  
Author(s):  
I. E. Vasil’ev ◽  
Yu. G. Matvienko ◽  
A. V. Pankov ◽  
A. G. Kalinin
Keyword(s):  
Acoustic Emission ◽  
Damage Detection ◽  
High Speed ◽  
Early Stage ◽  
Video Data ◽  
High Speed Video ◽  
Damage Diagnostics ◽  
Subsurface Defect ◽  
Sensitive Coating ◽  
Early Damage

The results of using early damage diagnostics technique (developed in the Mechanical Engineering Research Institute of the Russian Academy of Sciences (IMASH RAN) for detecting the latent damage of an aviation panel made of composite material upon bench tensile tests are presented. We have assessed the capabilities of the developed technique and software regarding damage detection at the early stage of panel loading in conditions of elastic strain of the material using brittle strain-sensitive coating and simultaneous crack detection in the coating with a high-speed video camera “Video-print” and acoustic emission system “A-Line 32D.” When revealing a subsurface defect (a notch of the middle stringer) of the aviation panel, the general concept of damage detection at the early stage of loading in conditions of elastic behavior of the material was also tested in the course of the experiment, as well as the software specially developed for cluster analysis and classification of detected location pulses along with the equipment and software for simultaneous recording of video data flows and arrays of acoustic emission (AE) data. Synchronous recording of video images and AE pulses ensured precise control of the cracking process in the brittle strain-sensitive coating (tensocoating)at all stages of the experiment, whereas the use of structural-phenomenological approach kept track of the main trends in damage accumulation at different structural levels and identify the sources of their origin when classifying recorded AE data arrays. The combined use of oxide tensocoatings and high-speed video recording synchronized with the AE control system, provide the possibility of definite determination of the subsurface defect, reveal the maximum principal strains in the area of crack formation, quantify them and identify the main sources of AE signals upon monitoring the state of the aviation panel under loading P = 90 kN, which is about 12% of the critical load.

Aflatoxins biosynthesis, toxicity and intervention strategies: A review

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Developing Countries ◽  
Molecular Basis ◽  
Genetic Regulation ◽  
Intervention Strategies ◽  
Historical Background ◽  
Economic Losses ◽  
Factors Affecting ◽  
Biomarkers Of Exposure ◽  
Food Commodities

Aflatoxins (AFTs) are toxic products of fungal metabolism, associated with serious health consequences and substantial economic losses to agriculture, livestock and poultry sectors, particularly in the developing countries. This review outlines the current information on AFTs in terms of historical background, classification, relative occurrence and co-existence with other mycotoxins in various food commodities. The phenomenon of aflatoxin (AFT) biosynthesis has been elucidated with reference to molecular basis, genetic regulation and factors affecting the AFT production. Moreover, the in vivo disposition kinetics, toxicological action and toxico-pathological consequences of AFTs have also been highlighted. Currently employed strategies for the detection and detoxification of AFTs, biomarkers of exposure assessment, potential economic impact and regulatory considerations regarding the AFTs have been emphasized.

Biomarkers of exposure and effect in the armoured catfish Hoplosternum littorale during a rice production cycle

2021 ◽  
pp. 117356
Author(s):  
Noelia Fantón ◽  
Jimena Cazenave ◽  
Melina P. Michlig ◽  
María R. Repetti ◽  
Andrea Rossi
Keyword(s):  
Rice Production ◽  
Production Cycle ◽  
Biomarkers Of Exposure ◽  
Armoured Catfish ◽  
Hoplosternum Littorale

scholarly journals Tezepelumab: A Potential New Biological Therapy for Severe Refractory Asthma

2021 ◽  
Vol 22 (9) ◽  
pp. 4369
Author(s):  
Corrado Pelaia ◽  
Giulia Pelaia ◽  
Claudia Crimi ◽  
Angelantonio Maglio ◽  
Luca Gallelli ◽  
...  
Keyword(s):  
Randomized Clinical Trials ◽  
Human Monoclonal Antibody ◽  
Airway Epithelial Cells ◽  
Lymphoid Cells ◽  
Airway Epithelial ◽  
Airborne Pollutants ◽  
Group 2 ◽  
Efficacy Profile ◽  
Refractory Asthma

Thymic stromal lymphopoietin (TSLP) is an innate cytokine, belonging to the group of alarmins, which plays a key pathogenic role in asthma by acting as an upstream activator of cellular and molecular pathways leading to type 2 (T2-high) airway inflammation. Released from airway epithelial cells upon tissue damage induced by several noxious agents including allergens, viruses, bacteria, and airborne pollutants, TSLP activates dendritic cells and group 2 innate lymphoid cells involved in the pathobiology of T2-high asthma. Tezepelumab is a fully human monoclonal antibody that binds to TSLP, thereby preventing its interaction with the TSLP receptor complex. Preliminary results of randomized clinical trials suggest that tezepelumab is characterized by a good safety and efficacy profile in patients with severe, uncontrolled asthma.

scholarly journals Toxic metals in toenails as biomarkers of exposure: A review

2021 ◽  
Vol 197 ◽  
pp. 111028
Author(s):  
Inmaculada Salcedo-Bellido ◽  
Enrique Gutiérrez-González ◽  
Esther García-Esquinas ◽  
Nerea Fernández de Larrea-Baz ◽  
Ana Navas-Acien ◽  
...  
Keyword(s):  
Toxic Metals ◽  
Biomarkers Of Exposure

scholarly journals Cytotoxic Effects of N,N-Diethyl-Meta-Toluamide (DEET) on Sinonasal Epithelia

OTO Open ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 2473974X2110092
Author(s):  
Jivianne T. Lee ◽  
Saroj Basak
Keyword(s):  
Cell Viability ◽  
Chronic Rhinosinusitis ◽  
Morphological Changes ◽  
Environmental Toxicants ◽  
Cytotoxic Effects ◽  
Airborne Pollutants ◽  
Cell Monitoring ◽  
History Of ◽  
And Control ◽  
Dose Dependent

Although the etiology of chronic rhinosinusitis remains unknown, environmental factors including airborne pollutants and toxicants are postulated to contribute to its pathogenesis. However, the precise pathomechanisms with which environmental toxicants may contribute to chronic rhinosinusitis are not fully understood. The purpose of this pilot study is to examine the cytotoxic effects of N,N-diethyl- meta-toluamide (DEET), a commonly used pesticide, on sinonasal epithelial cells (SNECs). Sinus mucosa was obtained from 3 subjects without a history of chronic rhinosinusitis. Cultured SNECs were exposed to various concentrations of DEET (0-5 mM) for 6 days. Cell viability, proliferation, and morphologic changes were assessed using the MTT colorimetric dye assay and the Incucyte Live Cell Monitoring System. Statistically significant dose-dependent reduction in cell viability and proliferation was observed between exposure and control groups ( P < .05) at all concentrations tested. Dose-dependent cellular morphological changes were also seen. These findings indicate that DEET exposure induces dose-dependent cytotoxicity in sinonasal epithelia.

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