Renal transplant recipients suffer significantly more complications but not mortality after breast cancer surgery and benefit from treatment at transplant centers

De novo breast cancer in renal transplant recipients

Transplantation Proceedings ◽

10.1016/s0041-1345(02)03063-4 ◽

2002 ◽

Vol 34 (5) ◽

pp. 1778-1779 ◽

Cited By ~ 10

Author(s):

J.F Buell ◽

M.J Hanaway ◽

J Trofe ◽

T.G Gross ◽

T.M Beebe ◽

...

Keyword(s):

Breast Cancer ◽

Renal Transplant ◽

De Novo ◽

Renal Transplant Recipients ◽

Transplant Recipients

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Liver Transplant Recipients Incur More Costly Care When Undergoing Treatment for Breast Cancer

10.21203/rs.3.rs-706435/v1 ◽

2021 ◽

Author(s):

Gregory Veillette ◽

Maria Castaldi ◽

Sacha A Roberts ◽

Afshin Parsikia ◽

Ankur Choubey ◽

...

Keyword(s):

Breast Cancer ◽

Multivariate Analysis ◽

Risk Factor ◽

Liver Transplant ◽

Independent Risk Factor ◽

Cancer Surgery ◽

Breast Cancer Surgery ◽

Transplant Recipients ◽

Operative Complications ◽

Liver Transplant Recipients

Abstract Purpose The incidence of breast cancer (BC) in solid organ transplant recipients is comparable to the age-matched general population. It is among the three top-most commonly occurring cancers in women after liver transplantation (LT). There is limited information on the management and outcomes of breast cancer in liver transplant recipients (LTR). We aim to evaluate the impact of LT on breast cancer surgery outcomes. Further we compare the outcomes after breast cancer surgery in LTR in transplant versus non-transplant centers. Methods National Inpatient Sample (NIS) database was accessed to identify LTR with BC. Mortality, complications, hospital charges and total length of stay (LOS) were evaluated with multivariate logistic regression testing. Weighted multivariate regression models were employed to compare outcomes at transplant and non-transplant centers. Results Ninety-nine women met inclusion criteria for LT + BC and were compared against a cohort of women with BC without LT (n = 736,527). LT + BC had lower performance status as confirmed via higher Elixhauser Comorbidity Index (20.5% vs.10.2%, p < 0001). There were significantly more complications in the LT cohort when compared to the non-LTR (15.0% vs. 8.2%, p = 0.012). However, on multivariate analysis, LT was not an independent risk factor for post-operative complications following breast cancer surgery (OR 1.223, p = 0.480). Cost associated with breast cancer care was significantly higher in those with LT (2.621, p < 0.001). Breast conservation surgery in LT had shorter LOS as compared to BC alone (OR 0.568, p 0.027) in all hospitals. Conclusion LT does not increase short-term mortality when undergoing breast cancer surgery. Although there were significantly more complications in the LT cohort when compared to the non-LTR (15.0% vs. 8.2%, p = 0.012), on multivariate analysis, LT was not an independent risk factor for post-operative complications following breast cancer surgery. Additionally, breast cancer treatment is more costly in LTR.

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Liver Transplantation Does Not Increase Morbidity or Mortality in Women Undergoing Surgery for Breast Cancer

10.21203/rs.3.rs-928737/v1 ◽

2021 ◽

Author(s):

Gregory Veillette ◽

Maria Castaldi ◽

Sacha Roberts ◽

Afshin Parsikia ◽

Ankur Choubey ◽

...

Keyword(s):

Breast Cancer ◽

Liver Transplantation ◽

Multivariate Analysis ◽

Risk Factor ◽

Independent Risk Factor ◽

Cancer Surgery ◽

Breast Cancer Surgery ◽

Transplant Recipients ◽

Cancer Management ◽

Breast Cancer Management

Abstract Purpose The incidence of breast cancer (BC) in solid organ transplant recipients is comparable to the age-matched general population. The rate of reported de novo breast cancer following liver transplantation (LT) varies. Further, there is limited information on the management and outcomes of breast cancer in liver transplant recipients (LTR). We aim to evaluate the impact of LT on breast cancer surgery outcomes. Further we compare the outcomes after breast cancer surgery in LTR in transplant versus non-transplant centers. Methods National Inpatient Sample (NIS) database was accessed to identify LTR with BC. Mortality, complications, hospital charges and total length of stay (LOS) were evaluated with multivariate logistic regression testing. Weighted multivariate regression models were employed to compare outcomes at transplant and non-transplant centers. Results Ninety-nine women met inclusion criteria for LT + BC and were compared against a cohort of women with BC without LT (n=736,527). LT + BC had lower performance status as confirmed via higher Elixhauser Comorbidity Index (20.5% vs.10.2%, p < 0001). There were significantly more complications in the LT cohort when compared to the non-LTR (15.0% vs. 8.2%, p=0.012). However, on multivariate analysis, LT was not an independent risk factor for post-operative complications following breast cancer surgery (OR 1.223, p=0.480). Cost associated with breast cancer care was significantly higher in those with LT (2.621, p<0.001). Breast conservation surgery in LT had shorter LOS as compared to BC alone (OR 0.568, p 0.027) in all hospitals. Conclusion LT does not increase short-term mortality when undergoing breast cancer surgery. Although there were significantly more complications in the LT cohort when compared to the non-LTR (15.0% vs. 8.2%, p=0.012), on multivariate analysis, LT was not an independent risk factor for postoperative complications following breast cancer surgery. Additionally, breast cancer treatment is more costly in LTR. Breast cancer management in LTR at non-transplant centers incurred higher charges but no difference in complication rate, nor LOS when compared to breast cancer management in LTR at transplant centers.

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