scholarly journals Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A

2021 ◽  
pp. 21027
Author(s):  
Sachiko Komatsu ◽  
Keyword(s):  
Cyclosporin A ◽  
Electrochemical Detection ◽  
Nitroxyl Radical ◽  
Electrochemical Evaluation

scholarly journals Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A

2020 ◽  
Author(s):  
Sachiko Komatsu ◽  
Yusuke Sasano ◽  
Kyoko Sugiyama ◽  
Kazuhiro Watanabe ◽  
Masayuki Kumano ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Electrochemical Detection ◽  
Nitroxyl Radical ◽  
Alcohol Concentration ◽  
Oxidation Potential ◽  
Nitroxyl Radicals ◽  
Hydroxyl Group ◽  
Acetonitrile Solution ◽  
Oxidation Current ◽  
Electrochemical Evaluation

Nitroxyl radical catalysts oxidize alcohols under an applied electric potential. It is possible to quantify the alcohol concentration from the resulting oxidation current. In this work, we evaluated the catalytic activity of nitroxyl radicals (or their corresponding hydroxylamines), including 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) as representative nitroxyl radicals, acetoamido-TEMPO, which shows higher oxidation potential than TEMPO owing to the acetoamido group, AZADO, Nor-AZADO, and NNO as less-hindered bicyclic nitroxyl radicals, and NHPI as an N,N-diacyl-type hydroxylamine, in acetonitrile solution. TEMPO, AZADO and NNO were also evaluated for their ability to oxidize alcohols in organic solvents, and their reactivity was compared with the electrochemical response. The most active NNO was used for electrochemical detection of cyclosporin A, a drug with a hydroxyl group.

scholarly journals A local redox cycling-based electrochemical chip device with nanocavities for multi-electrochemical evaluation of embryoid bodies

Lab on a Chip ◽  
2015 ◽  
Vol 15 (23) ◽  
pp. 4404-4414 ◽  
Author(s):  
Yusuke Kanno ◽  
Kosuke Ino ◽  
Hitoshi Shiku ◽  
Tomokazu Matsue
Keyword(s):  
Electrochemical Detection ◽  
Cell Activity ◽  
Redox Cycling ◽  
Embryoid Bodies ◽  
Electrochemical Evaluation

We developed a local redox cycling-based electrochemical (LRC-EC) device with nanocavities for multi-electrochemical detection of cell activity.

1869: Combined Therapy of FR167653 and Cyclosporin A Significantly Prolonged Animal Survival in ratRenal Allografts

2004 ◽  
Vol 171 (4S) ◽  
pp. 493-494
Author(s):  
Haruhito Azuma ◽  
Shiro Takahara ◽  
Takashi Wada ◽  
Takeshi Sakamoto ◽  
Akihiko Okuyama ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Combined Therapy ◽  
Animal Survival
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