scholarly journals A new fructose-free, resistant-starch type IV-enriched enteral formula improves glycaemic control and cardiovascular risk biomarkers when administered for six weeks to elderly diabetic patients

2017 ◽  
Vol 34 (1) ◽  
pp. 73 ◽  
Author(s):  
María Dolores Mesa García ◽  
Cruz Erika García-Rodríguez ◽  
María de la Cruz Rico ◽  
Concepción María Aguilera ◽  
Milagros Pérez-Rodríguez ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Glycaemic Control ◽  
Resistant Starch ◽  
Diabetic Patients ◽  
Type Iv ◽  
Enteral Formula ◽  
Risk Biomarkers

scholarly journals Diabetes Management – Lowering Cardiovascular Risk

2014 ◽  
Vol 9 (1) ◽  
pp. 7
Author(s):  
Dan Gaiţă ◽  
Svetlana Moşteoru ◽  
Laurence Sperling ◽  
◽  
◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Glycaemic Control ◽  
Multidisciplinary Approach ◽  
Diabetes Management ◽  
Microvascular Complications ◽  
Diabetic Patients ◽  
High Cardiovascular Risk ◽  
Hypoglycaemic Agents ◽  
Artery Disease ◽  
Shed Light

Diabetes mellitus is one of the most common diseases to plague the present day. Sixty percent of mortality in diabetic patients is caused by coronary artery disease. Numerous studies have shown that improving glycaemic control helps manage microvascular complications. On the other hand, some studies have shed light on the fact that a too tight glycaemic control can have adverse effects, especially on patients with high cardiovascular risk. Thus ‘the lower the better’ attitude should be exchanged for ‘the earliest the best’ attitude. A multidisciplinary approach should therefore be undertaken in order to achieve a proper management of the cardiovascular risk for diabetic patients. This includes using hypoglycaemic agents, antihypertensive medication and statins to balance the myriad of cardiovascular risk factors.

Postprandial glucose, insulin and gastrointestinal hormones in healthy and diabetic subjects fed a fructose-free and resistant starch type IV-enriched enteral formula

2012 ◽  
Vol 52 (6) ◽  
pp. 1569-1578 ◽  
Author(s):  
Cruz Erika García-Rodríguez ◽  
María Dolores Mesa ◽  
Josune Olza ◽  
Gilda Buccianti ◽  
Milagros Pérez ◽  
...  
Keyword(s):  
Resistant Starch ◽  
Gastrointestinal Hormones ◽  
Postprandial Glucose ◽  
Type Iv ◽  
Enteral Formula

scholarly journals Changes in Oxidative Stress and Inflammatory Biomarkers in Fragile Adults over Fifty Years of Age and in Elderly People Exclusively Fed Enteral Nutrition

2016 ◽  
Vol 2016 ◽  
pp. 1-11
Author(s):  
Maria D. Mesa ◽  
Josune Olza ◽  
Carolina Gonzalez-Anton ◽  
Concepcion M. Aguilera ◽  
Rosario Moreno-Torres ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Risk ◽  
Reference Group ◽  
Elderly Subjects ◽  
Enteral Diet ◽  
Plasma Antioxidant Capacity ◽  
Antioxidant Defence System ◽  
Enteral Formula ◽  
Risk Biomarkers ◽  
Plasma Antioxidant

We aim to evaluate whether exclusive feeding of an enteral formula enriched withn-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA) affects oxidative stress and the antioxidant defence system and may improve the levels of some relevant inflammatory, and cardiovascular biomarkers in frail adults over fifty years of age and in elderly subjects. Fifty-five patients were divided into two groups and were exclusively fed a newly designed normoproteic and isocaloric enteral formula enriched with eicosapentaenoic (98 mg/d) and docosahexaenoic acids (46 mg/d) (n=26) or a reference enteral diet (n=29). Oxidative, inflammatory and cardiovascular risk biomarkers and red blood cell fatty acid profiles were determined at the beginning and after 90 and 180 days of feeding. Then-3 LC-PUFA percentage tended to be higher (P=0.053) in the experimental group than in the reference group. Administration of then-3 LC-PUFA diet did not increase oxidative stress or modify plasma antioxidant capacity but decreased antioxidant enzymatic activities. MMP-9 plasma concentration decreased with both formulae, whereas tPAI-1 tended to decrease (P=0.116) with the administration of the experimental formula. In conclusion, administration of the newn-3 LC-PUFA-enriched product for 6 months did not negatively alter the oxidative status and improved some cardiovascular risk biomarkers.

PO19-573 EMERGING CARDIOVASCULAR RISK BIOMARKERS IN TYPE 2 DIABETIC PATIENTS WITH SUBCLINICAL ATHEROSCLEROTIC DISEASE

2007 ◽  
Vol 8 (1) ◽  
pp. 157-158
Author(s):  
M.M. Jarabo-Bueno ◽  
A. Lopez-Ruiz ◽  
C. Banyuls-Morant ◽  
J. Yanini ◽  
M.L. Martinez-Triguero ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Atherosclerotic Disease ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Risk Biomarkers ◽  
Type 2 Diabetic

scholarly journals Study of highly sensitive C-reactive protein in type 2 diabetes mellitus and prediction of cardiovascular risk with glycemic status

2019 ◽  
Vol 6 (3) ◽  
pp. 687
Author(s):  
T. Doraickannu ◽  
T. Sechassayana ◽  
S. Vithiavathi ◽  
Momin Varisali
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Risk ◽  
Glycaemic Control ◽  
Inflammatory Markers ◽  
Vital Role ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
Hs Crp

Inflammation plays a vital role in accentuating the formation of atherosclerotic plaque in diabetes mellitus. So, the measurements of inflammatory markers provide a method of assessing cardiovascular risk. Among the inflammatory markers, highly sensitive C-reactive protein (hs-CRP) is used to detect the low-level inflammation when it is within the normal range. Also, hs-CRP measurement may be useful for assessment of the risk of complication in diabetes patients. So, the present study is conducted to measure plasma hs-CRP level in T2DM and to determine adequate glycaemic control reduces hs-CRP level. The objectives of this study were to correlate HbA1c and hs-CRP in T2DM and predict cardiovascular risk with glycaemic status.Methods: Authors took 50 diabetic patients. The investigation includes FBS, PPBS, hs-CRP and HbA1c. hs-CRP is measured by immunoturbidimetry method. The reports were collected and compared with normal reference range.Results: The correlation between hs-CRP levels and HbA1c level after six months show a significant relationship where mean HbA1c values on day 1 and after 6 months were 8.088±1.219 and 7.518±0.693 respectively. The hs-CRP values were 2.508±1.050 on day 1 and 2.15±0.927 after 6 months proving that better glycaemic controls decrease hs-CRP thereby decreasing cardiovascular risk.Conclusions: hs-CRP values are directly related to HbA1c and better glycaemic control reduces risk of CVD.

scholarly journals 112 Safety and biochemical efficacy of sodium–glucose cotransporter 2 inhibitors based on cardiovascular risk profile and volume status in a real-world diabetic population

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Mauro Gitto ◽  
Alexios Kotinas ◽  
Riccardo Terzi ◽  
Angelo Oliva ◽  
Jorgele Zagoreo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Risk ◽  
Glycaemic Control ◽  
Real World ◽  
Glycated Haemoglobin ◽  
Diabetic Patients ◽  
World Population ◽  
High Cardiovascular Risk ◽  
Sodium Glucose Cotransporter ◽  
Tract Infections

Abstract Aims Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have become a first-line cardiovascular medication. However, their potential side effects still limit a widespread use in real-world clinical practice. Further, there is uncertainty about the mechanisms mediating SGLT2i-associated cardiovascular benefit. Methods We performed a retrospective analysis on consecutive diabetic patients who were prescribed a SGLT2i in a tertiary referral centre. Patients who completed at least 1 year of treatment were included in the data analysis. Changes in glycated haemoglobin, weight and haematocrit were evaluated and compared across two cardiovascular risk categories, defined through the inclusion criteria of three large randomized clinical trials. Additionally, a modified clinical score (mH2FPEF) was applied to detect the probability of heart failure with preserved ejection fraction (HFpEF). Results Of the 459 patients screened from 2015 to 2020, 312 completed 1 year of treatment (68.0%), 92 interrupted the treatment prematurely (20.0%) and 55 were lost to follow-up (12.0%). The most common causes of drug discontinuation were genital or urinary tract infections (9.4%) and poor glycaemic control (5%). At 1 year, a significant reduction in glycated haemoglobin concentration (−0.6 ± 1.4%, P < 0.001) and body weight (2.4 ± 4.6 Kg, P < 0.001) was observed and was comparable between patients at high vs. low cardiovascular risk. Haematocrit increase at 1 year (2.3 ± 3.3%, P < 0.001) was more marked in patients with high cardiovascular risk and low baseline haematocrit. Among patients with no established heart failure (N = 295), 156 (52.9%) had >50% probability of HFpEF (mH2FPEF ≥3). Conclusions In a real-world population of diabetic patients, SGLT2i were well-tolerated at 1 year and led to improved glycaemic control and weight loss. Haematocrit increase was more consistent in patients with high cardiovascular risk and signs of fluid overload, indicating the potentially beneficial role of euvolemic restoration. More than half of these diabetic patients had a high likelihood of unrecognized HFpEF.

scholarly journals Effectiveness of Brisk Walking Exercise on Glycaemic Control and Cardio-Vascular Risk Factors in Patients with Type 2 Diabetes

2020 ◽  
Vol 10 (4-s) ◽  
pp. 53-62
Author(s):  
Dalila LAKHDAR ◽  
Mustapha DIAF ◽  
Méghit Boumediene KHALED
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Glycaemic Control ◽  
Physical Performance ◽  
Biochemical Parameters ◽  
Diabetic Patients ◽  
Brisk Walking ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Objective: Our aim is to evaluate the effect of brisk walking exercise on anthropometric characteristics, blood parameters, physical performance and cardiovascular risk in Algerian type 2 diabetic patients. Methods: A comparative interventional study was performed in Mascara (north-western Algeria) on patients with type 2 diabetes. All participants were subjected to a physical activity program that consisted of brisk walking sessions during seven months. Anthropometric characteristics, biochemical parameters, physical performance and cardiovascular risk indices were evaluated and compared between the two genders.  Results: Fifty-three (22 men and 31 women) type 2 diabetic patients with were involved in the study. The mean age of all participants was 50.86±11.07 years. No difference between the two genders was observed with respect to age, anthropometrics, systolic blood pressure, maximal oxygen consumption (VO2max) and all biochemical parameters and lipid ratios. A gradual decrease in most anthropometric, clinical, biochemical parameters, and blood pressure levels have been disclosed after seven-month (28 weeks) of follow-up of the brisk walking programme. Higher significant decreases (p<0.001) in fasting, post-effort and postprandial blood glycaemia were observed in both genders during all stages of our study. No significant differences were showed on lipid ratios; moreover, the majority of lipid ratios values were within the normal thresholds. The entirely recorded values of VO2max, body mass index (BMI) and heart rate were slightly higher in females comparing to males with both levels of glycated haemoglobin. Conclusion: The practice of three brisk walking sessions per week at a rate of 30 minutes each has beneficial impact on anthropometric parameters, biochemical parameters, physical performance, glycaemic control and on the reduction of cardiovascular risk in type 2 diabetic patients of both genders. Keywords: Brisk walking, Type 2 diabetes, Glycaemic control, Blood parameters, Cardiovascular risk

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