scholarly journals BONE MINERAL DENSITY, LUNG FUNCTION, VITAMIN D AND BODY COMPOSITION IN CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS: MULTICENTER STUDY.

2018 ◽  
Author(s):  
Paulina Bravo M. ◽  
Sergio Gerardo Weisstaub ◽  
Paulina Balboa ◽  
Claudia Torrejón ◽  
Rodrigo Bozzo ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cystic Fibrosis ◽  
Vitamin D ◽  
Body Composition ◽  
Lung Function ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Multicenter Study ◽  
Mineral Density

scholarly journals Nutritional factors associated with femoral neck bone mineral density in children and adolescents

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Guo-Hau Gou ◽  
Feng-Jen Tseng ◽  
Sheng-Hao Wang ◽  
Pao-Ju Chen ◽  
Jia-Fwu Shyu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Femoral Neck ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Age Group ◽  
Mineral Density ◽  
Nutrient Intakes ◽  
Nutritional Factors ◽  
Daily Total

Abstract Background Nutritional factors including vitamin D, magnesium, and fat are known to affect bone mineral accrual. This study aimed to evaluate associations between dietary nutrient intakes (both macronutrients and micronutrients) and bone mineral density (BMD) in children and adolescents. Methods Data for this cross-sectional, population-based study were derived from the National Health and Nutrition Examination Survey (NHANES). Participants aged from 8 to 19 years were included. The primary outcome was femoral neck BMD. Results Multivariate analyses revealed that for participants aged 8 to 11, daily sodium intake was significantly and positively associated with femoral neck BMD (B = 0.9 ×  10− 5, p = 0.031); in particular, subgroup analyses by sex found that in male participants aged 8–11, daily total cholesterol intake (B = 5.3 × 10− 5, p = 0.030) and calcium intake (B = − 2.0 × 10− 5, p < 0.05) were significantly associated with femoral neck BMD in a positive and negative manner, respectively, but neither were observed in female participants of this age group. In contrast, daily intakes of vitamin D and magnesium were significantly and positively associated with femoral neck BMD in female participants aged 8–11 (B = 246.8 × 10− 5 and 16.3 × 10− 5, p = 0.017 and 0.033, respectively). For participants aged 16 to 19, daily total fat intake was significantly and negatively associated with femoral neck BMD (B = − 58 × 10− 5, p = 0.048); further stratification by sex found that magnesium and sodium intakes were significantly and positively associated with femoral neck BMD only in females of this age group (B = 26.9 × 10− 5 and 2.1 × 10− 5, respectively; both p < 0.05). However, no significant associations between daily nutrient intakes and femoral neck BMD were identified in participants aged 12–15 before or after subgroup stratification. Conclusion The study found that associations of specific nutrition-related variables with BMD of the femoral neck is dependent upon age and gender.

scholarly journals Bone mineral density and vitamin D concentration: the challenges in taking care of children and adolescents infected with HIV

2017 ◽  
Vol 21 (3) ◽  
pp. 270-275 ◽  
Author(s):  
Fabiana Bononi Carmo ◽  
Maria Teresa Terreri ◽  
Regina Célia de Menezes Succi ◽  
Suenia Vasconcelos Beltrão ◽  
Aida de Fátima Tomé Barbosa Gouvea ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Mineral Density ◽  
Taking Care

scholarly journals Bone mineral density in young adults: the influence of vitamin D status, biochemical indicators, physical activity and body composition

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Anna Kopiczko ◽  
Monika Łopuszańska-Dawid ◽  
Karol Gryko
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Vitamin D ◽  
Body Composition ◽  
Total Cholesterol ◽  
Bone Mineral ◽  
Activity Levels ◽  
Fat Percentage ◽  
Mineral Density ◽  
Physical Activity Levels

Abstract Summary The aim of the study was to assess the associations of bone mineral density and bone mass with physical activity levels, vitamin D, phosphorus, magnesium, total cholesterol and triglyceride concentration and body composition in young women and men. Physical activity has the most significant effect on bone status especially in men. Purpose The aim of the study was to assess the associations of bone mineral density and bone mass with physical activity levels, vitamin D, phosphorus, magnesium, total cholesterol and triglyceride concentration and body composition in young women and men. Methods One hundred subjects aged 19–24 years were included. Bone mineral density (BMD) in distal and proximal parts was evaluated by forearm densitometry. Body composition was analysed with the use of JAWON-Medical-x-scan. The following biochemical indicators were analysed: 25(OH) D and 1,25(OH)2D, magnesium, phosphorus, total cholesterol and triglycerides. Physical activity levels were assessed by interview. Results Significant correlations between BMD and physical activity, skeletal muscle mass and body fat percentage were revealed in men. Among women, considerably weaker correlations of BMD with body composition and physical activity were noted than in men. BMD in the distal part correlated only with lean body mass, soft lean mass and body fat percentage. The strongest relationship between physical activity and bone mineral status parameters was noted for BMD in men. In women, physical activity did not affect BMD. Conclusions Physical activity has the most significant effect on bone status especially in men.

Bone mineral density and lean body mass in children and adolescents with cystic fibrosis

Bone ◽  
2009 ◽  
Vol 45 ◽  
pp. S72
Author(s):  
M. van Huis ◽  
J.C. Escher ◽  
P.J.F.M. Merkus ◽  
N. van Eldik ◽  
J.J.E. Hendriks ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cystic Fibrosis ◽  
Children And Adolescents ◽  
Lean Body Mass ◽  
Body Mass ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Bone mineral density and quantitative ultrasound in children and adolescents with cystic fibrosis

2010 ◽  
Vol 9 ◽  
pp. S84 ◽  
Author(s):  
E. Hatziagorou ◽  
A. Christoforidis ◽  
V. Avramidou ◽  
E. Kazantzidou ◽  
F. Kirvassilis ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cystic Fibrosis ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Quantitative Ultrasound ◽  
Mineral Density

scholarly journals Association between Body Composition and Bone Mineral Density in Children and Adolescents: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (22) ◽  
pp. 12126
Author(s):  
Kai-Li Deng ◽  
Wan-Yu Yang ◽  
Jin-Li Hou ◽  
Hui Li ◽  
Hao Feng ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Systematic Review ◽  
Body Composition ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Correlation Coefficients ◽  
Regression Coefficients ◽  
Mineral Density ◽  
Total Body

Background: Bone mass acquisition during growth is a major determinant of the risk of developing osteoporosis later in life. Body composition is an anthropometric determinant of bone mineral density (BMD) and significantly influences its development during childhood and adolescence. Objective: This study aimed to systematically examine the association between body composition and bone mineral density in children and adolescents. Methods: Observational studies addressing this association were identified from PubMed (MEDLINE), Embase, Scopus and the Cochrane Library (up to January 2021). The study populations consisted of healthy children and adolescents. The DerSimonian and Laird method was used to compute pooled estimates of effect size and the respective 95% confidence intervals for upper limbs, femoral neck (FN), lumbar spine (LS) and total body, respectively. Subgroup analyses were further performed based on age, sex and ethnicity. Results: Thirty-one published studies were eligible for inclusion in this systematic review and meta-analysis, including three longitudinal studies. The combined population from all the studies amounted to 21,393 (11,205 males and 10,188 females). The pooled estimates of the correlation coefficients for lean mass (LM) and BMD ranged from 0.53 to 0.74 (p < 0.050), and the pooled regression coefficients ranged from 0.23 to 0.79 for FN, LS and total body (p < 0.050). For fat mass (FM), the pooled correlation coefficients ranged from 0.10 to 0.50 (p < 0.050) and the pooled regression coefficient was only significant for FN BMD with a weak strength (pooled β = 0.07, p < 0.050). The pooled regression coefficients for body fat percentage (BF%) were between −0.54 and −0.04 (p < 0.050). The subgroup analysis revealed a stronger association in Asians than in Caucasians for LM and in males compared to females for BF% (p < 0.050). Conclusions: This systematic review and meta-analysis supports a positive association between LM and BMD. BF% appears to have a deleterious effect on bone acquisition in children and adolescents.

scholarly journals Alendronate Improves Bone Mineral Density in Children and Adolescents Perinatally Infected With Human Immunodeficiency Virus With Low Bone Mineral Density for Age

2019 ◽  
Vol 71 (5) ◽  
pp. 1281-1288 ◽  
Author(s):  
Denise L Jacobson ◽  
Jane C Lindsey ◽  
Catherine Gordon ◽  
Rohan Hazra ◽  
Hans Spiegel ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Human Immunodeficiency Virus ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Whole Body ◽  
Mineral Density ◽  
Safety And Efficacy ◽  
Immunodeficiency Virus ◽  
Perinatally Infected

Abstract Background Children and adolescents with perinatal human immunodeficiency virus (HIV) infection and with low bone mineral density (BMD) may be at higher risk of osteoporosis and fractures in later life than their uninfected peers. Bisphosphonate therapy has been shown to reduce fractures in adults with osteoporosis, but has not been formally studied in youths living with HIV. Methods Fifty-two children and adolescents (aged 11–24 years) perinatally infected with HIV with low lumbar spine (LS) BMD (Z score &lt; −1.5) were randomized to receive once-weekly alendronate or placebo in a double-blind cross-over study designed to assess the safety and efficacy of 48 and 96 weeks of alendronate in the United States and Brazil. All participants received daily calcium carbonate and vitamin D supplementation and were asked to engage in regular weight-bearing exercise. Safety and efficacy are summarized for the initial 48 weeks of the trial. Results Grade 3 or higher abnormal laboratory values, signs, or symptoms developed in 5 of 32 (16%) participants on alendronate and 2 of 18 (11%) on placebo (P &gt; .99). No cases of jaw osteonecrosis, atrial fibrillation, or nonhealing fractures were reported. Mean increases (95% confidence interval) in LS BMD over 48 weeks were significantly larger on alendronate (20% [14%–25%]) than placebo (7% [5%–9%]) (P &lt; .001). Similar improvements were seen for whole body BMD. Conclusions In this small study in children and adolescents perinatally infected with HIV with low LS BMD, 48 weeks of alendronate was well-tolerated, showed no safety concerns, and significantly improved LS and whole body BMD compared to participants on vitamin D/calcium supplementation and exercise alone. Clinical Trials Registration NCT00921557.

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