scholarly journals Long-term outcome after bilateral adrenalectomy in Cushing’s disease with focus on Nelson’s syndrome

2019 ◽  
Author(s):  
Ana C. Cohen ◽  
Dolores Clifton Goldney ◽  
Karina Danilowicz ◽  
Marcos Manavela ◽  
María A. Rossi ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Bilateral Adrenalectomy ◽  
Cushing's Disease ◽  
Nelson’S Syndrome ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Nelson's Syndrome

Favorable long-term outcome of bilateral adrenalectomy in Cushing's disease

2014 ◽  
Author(s):  
Andrea Osswald ◽  
Eva Plomer ◽  
Christina Dimopoulou ◽  
Monika Milian ◽  
Rainer Blaser ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Bilateral Adrenalectomy ◽  
Cushing's Disease ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Nelson's Syndrome

2007 ◽  
Vol 51 (8) ◽  
pp. 1392-1396 ◽  
Author(s):  
Alia Munir ◽  
John Newell-Price
Keyword(s):  
Cushing’S Disease ◽  
Pituitary Tumour ◽  
Bilateral Adrenalectomy ◽  
Cushing's Disease ◽  
Treatment Modalities ◽  
Pituitary Mass ◽  
Nelson’S Syndrome ◽  
Nelson's Syndrome ◽  
Great Heterogeneity ◽  
The One

Nelson's syndrome is a potentially severe complication of bilateral adrenalectomy performed in the treatment of Cushing's disease, and its management remains difficult. Of all of the features of Nelson's syndrome, the one that causes most concern is the development of a locally aggressive pituitary tumour, which, unusually for pituitary disease, may occasionally cause death from the tumour itself. This feature is especially pertinent given the increasing use in Cushing's disease of laparoscopic bilateral adrenal surgery as a highly effective treatment modality to control cortisol-excess. Despite numerous studies and reports, there is no formal consensus of what defines Nelson's syndrome. Thus, some will define Nelson's syndrome according to the classical description with an evolving pituitary mass after bilateral adrenalectomy, whereas others will rely on increasing plasma ACTH levels, even in the absence of a clear pituitary mass lesion on MRI. These factors need to be borne in mind when considering the reports of Nelson's syndrome, as there is great heterogeneity, and it is likely that overall the modern 'Nelson's syndrome' represents a different disease entity from that of the last century. In the present paper, clinical and epidemiological features of Nelson's syndrome, as well as its treatment modalities, are reviewed.

Nelson’s syndrome after bilateral adrenalectomy for Cushing’s disease

Surgery ◽  
2007 ◽  
Vol 141 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Alejandra Gil-Cárdenas ◽  
Miguel F. Herrera ◽  
Araceli Díaz-Polanco ◽  
Juan Manuel Rios ◽  
Juan Pablo Pantoja
Keyword(s):  
Cushing’S Disease ◽  
Bilateral Adrenalectomy ◽  
Cushing's Disease ◽  
Nelson’S Syndrome ◽  
Nelson's Syndrome

MEGAVOLTAGE PITUITARY IRRADIATION IN THE MANAGEMENT OF CUSHING'S DISEASE AND NELSON'S SYNDROME: LONG-TERM FOLLOW-UP

1989 ◽  
Vol 31 (3) ◽  
pp. 309-323 ◽  
Author(s):  
T. A. HOWLETT ◽  
P. N. PLOWMAN ◽  
J. A. H. WASS ◽  
L. H. REES ◽  
A. E. JONES ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Nelson’S Syndrome ◽  
Nelson's Syndrome ◽  
Long Term Follow Up ◽  
Pituitary Irradiation

Long-term outcome of trans-sphenoidal surgery for Cushing’s disease in Indian patients

2018 ◽  
Vol 161 (1) ◽  
pp. 119-127 ◽  
Author(s):  
S. Saini ◽  
J. Kanwar ◽  
S. Gupta ◽  
S. Behari ◽  
E. Bhatia ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Indian Patients

Long Term Outcome in a Cohort of Patients with Cushing’s Disease Treated at a Single Center in the Netherlands.

2010 ◽  
pp. P1-276-P1-276
Author(s):  
G van den Berg ◽  
EW Hoving ◽  
MN Kerstens ◽  
MM van der Klauw ◽  
LC Meiners ◽  
...  
Keyword(s):  
The Netherlands ◽  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Single Center ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Long-term outcome in patients after treatment for Cushing’s disease in childhood

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0226033
Author(s):  
Katarzyna Pasternak-Pietrzak ◽  
Elżbieta Moszczyńska ◽  
Marcin Roszkowski ◽  
Karolina Kot ◽  
Elżbieta Marczak ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Transsphenoidal surgery for Cushing's disease: a review of success rates, remission predictors, management of failed surgery, and Nelson's Syndrome

2007 ◽  
Vol 23 (3) ◽  
pp. 1-6 ◽  
Author(s):  
Daniel F. Kelly
Keyword(s):  
Cushing’S Disease ◽  
Transsphenoidal Surgery ◽  
Remission Rate ◽  
Cushing's Disease ◽  
Surgical Morbidity ◽  
Nelson’S Syndrome ◽  
Nelson's Syndrome ◽  
Radio Therapy ◽  
Transsphenoidal Adenomectomy

✓ Cushing's disease is a serious endocrinopathy that, if left untreated, is associated with significant morbidity and mortality rates. After diagnostic confirmation of Cushing's disease has been made, transsphenoidal adenomectomy is the treatment of choice. When a transsphenoidal adenomectomy is performed at experienced transsphenoidal surgery centers, long-term remission rates average 80% overall, surgical morbidity is low, and the mortality rate is typically less than 1%. In patients with well-defined noninvasive microadenomas, the long-term remission rate averages 90%. For patients in whom primary surgery fails, treatment options such as bilateral adrenalectomy, stereotactic radiotherapy or radiosurgery, total hypophysectomy, or adrenolytic medical therapy need to be carefully considered, ideally in a multidisciplinary setting. The management of Nelson's Syndrome often requires both transsphenoidal surgery and radio-therapy to gain disease control.

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