Hypothesis: Relaxation Signaling in Human Myometrium

2021 ◽  
Author(s):  
Iain Buxton ◽  
Scott Barnett
Keyword(s):  
Human Myometrium

EXPERIMENTS ON THE ENDOCRINE CONTROL OF THE ACTIVITY OF THE NONPREGNANT HUMAN MYOMETRIUM

1965 ◽  
Vol 49 (3_Suppl) ◽  
pp. S202
Author(s):  
L. Ph. Bengtsson ◽  
G. W. Theobald
Keyword(s):  
Human Myometrium ◽  
Endocrine Control

scholarly journals Roles of endothelin-l(ET-1) and receptors in human myometrium and leiomyoma.

1999 ◽  
Vol 79 ◽  
pp. 57
Author(s):  
Masae Sakamoto ◽  
Shuichi Sakamoto ◽  
Akiko Nagai ◽  
Takeshi Aso ◽  
Hiroshi Masuda ◽  
...  
Keyword(s):  
Human Myometrium

scholarly journals Ethanolic Extracts of Adlay Testa and Hull and Their Active Biomolecules Exert Relaxing Effect on Uterine Muscle Contraction through Blocking Extracellular Calcium Influx in Ex Vivo and In Vivo Studies

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 887
Author(s):  
Yun-Ju Huang ◽  
Yu-Chieh Chen ◽  
Hsin-Yuan Chen ◽  
Yi-Fen Chiang ◽  
Mohamed Ali ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Uterine Contraction ◽  
Calcium Influx ◽  
Ex Vivo ◽  
Ethanolic Extract ◽  
Ethyl Acetate Fraction ◽  
In Vivo Studies ◽  
Human Myometrium ◽  
Writhing Test

Dysmenorrhea is one of the most prevalent disorders in gynecology. Historically, adlay (Coix lachryma-jobi L. var. Ma-yuen Stapf.) has been explored for its anti-tumor, pain relief, anti-inflammatory, and analgesic effects. The aim of this study was to evaluate the effects of adlay seeds on the inhibition of uterine contraction and thus dysmenorrhea relief, in vitro and in vivo. HPLC-MS and GC were used to elucidate the ethyl acetate fraction of adlay testa ethanolic extract (ATE-EA) and ethyl acetate fraction of adlay hull ethanolic extract (AHE-EA). Elucidation yielded flavonoids, phytosterols, and fatty acids. Uterine leiomyomas and normal adjacent myometrial tissue were evaluated by oxytocin- and PG-induced uterine contractility. ATE-EA and AHE-EA suppressed uterine contraction induced by prostaglandin F2 alpha (PGF2α), oxytocin, carbachol, and high-KCl solution ex vivo. In addition, the external calcium (Ca2+) influx induced contraction, and increased Ca2+ concentration was inhibited by ATE-EA and AHE-EA on the uterine smooth muscle of rats. Furthermore, ATE-EA and AHE-EA effectively attenuated the contraction of normal human myometrium tissues more than adjacent uterine leiomyoma in response to PGF2α. 3,5,6,7,8,3′,4′-Heptamethoxyflavone and chrysoeriol produced a remarkable inhibition with values of IC50 = 24.91 and 25.59 µM, respectively. The experimental results showed that treatment with ATE-EA at 30 mg/day effectively decreased the writhing frequency both on the oxytocin-induced writhing test and acetic acid writhing test of the ICR mouse.

The effects of methyl palmitate, a putative regulator from perivascular fat, on the contractility of pregnant human myometrium

Life Sciences ◽  
2014 ◽  
Vol 116 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Denis J. Crankshaw ◽  
Jennifer M. Walsh ◽  
John J. Morrison
Keyword(s):  
Methyl Palmitate ◽  
Human Myometrium ◽  
Perivascular Fat

Expression of connexin-43 in human myometrium and leiomyoma

1993 ◽  
Vol 169 (5) ◽  
pp. 1266-1276 ◽  
Author(s):  
Janet Andersen ◽  
Elizabeth Grine ◽  
Carla L.Y. Eng ◽  
Kun Zhao ◽  
Robert L. Barbieri ◽  
...  
Keyword(s):  
Connexin 43 ◽  
Human Myometrium
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