Global Variation in the Basic Reproduction Number of COVID-19

2021 ◽  
Author(s):  
Renate Thiede ◽  
Nada Abdelatif ◽  
Inger Fabris-Rotelli ◽  
Raeesa Manjoo-Docrat ◽  
Jennifer Holloway ◽  
...  
Keyword(s):  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Global Variation ◽  
The Basic Reproduction Number

scholarly journals Fractional SIR-Model for Estimating Transmission Dynamics of COVID-19 in India

J ◽  
2021 ◽  
Vol 4 (2) ◽  
pp. 86-100
Author(s):  
Nita H. Shah ◽  
Ankush H. Suthar ◽  
Ekta N. Jayswal ◽  
Ankit Sikarwar
Keyword(s):  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Transmission Rate ◽  
Sir Model ◽  
Time Dependent ◽  
Contact Rate ◽  
Distribution Maps ◽  
Fundamental Parameters ◽  
Different Order ◽  
The Basic Reproduction Number

In this article, a time-dependent susceptible-infected-recovered (SIR) model is constructed to investigate the transmission rate of COVID-19 in various regions of India. The model included the fundamental parameters on which the transmission rate of the infection is dependent, like the population density, contact rate, recovery rate, and intensity of the infection in the respective region. Looking at the great diversity in different geographic locations in India, we determined to calculate the basic reproduction number for all Indian districts based on the COVID-19 data till 7 July 2020. By preparing district-wise spatial distribution maps with the help of ArcGIS 10.2, the model was employed to show the effect of complete lockdown on the transmission rate of the COVID-19 infection in Indian districts. Moreover, with the model's transformation to the fractional ordered dynamical system, we found that the nature of the proposed SIR model is different for the different order of the systems. The sensitivity analysis of the basic reproduction number is done graphically which forecasts the change in the transmission rate of COVID-19 infection with change in different parameters. In the numerical simulation section, oscillations and variations in the model compartments are shown for two different situations, with and without lockdown.

scholarly journals Impact of early detection and vaccination strategy in COVID-19 eradication program in Jakarta, Indonesia

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Dipo Aldila ◽  
Brenda M. Samiadji ◽  
Gracia M. Simorangkir ◽  
Sarbaz H. A. Khosnaw ◽  
Muhammad Shahzad
Keyword(s):  
Mathematical Model ◽  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Vaccination Strategy ◽  
Vaccination Rate ◽  
Rapid Testing ◽  
Social Distancing ◽  
Rapid Spread ◽  
Vaccine Potential ◽  
The Basic Reproduction Number

Abstract Objective Several essential factors have played a crucial role in the spreading mechanism of COVID-19 (Coronavirus disease 2019) in the human population. These factors include undetected cases, asymptomatic cases, and several non-pharmaceutical interventions. Because of the rapid spread of COVID-19 worldwide, understanding the significance of these factors is crucial in determining whether COVID-19 will be eradicated or persist in the population. Hence, in this study, we establish a new mathematical model to predict the spread of COVID-19 considering mentioned factors. Results Infection detection and vaccination have the potential to eradicate COVID-19 from Jakarta. From the sensitivity analysis, we find that rapid testing is crucial in reducing the basic reproduction number when COVID-19 is endemic in the population rather than contact trace. Furthermore, our results indicate that a vaccination strategy has the potential to relax social distancing rules, while maintaining the basic reproduction number at the minimum possible, and also eradicate COVID-19 from the population with a higher vaccination rate. In conclusion, our model proposed a mathematical model that can be used by Jakarta’s government to relax social distancing policy by relying on future COVID-19 vaccine potential.

scholarly journals Mathematical analysis of a measles transmission dynamics model in Bangladesh with double dose vaccination

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Md Abdul Kuddus ◽  
M. Mohiuddin ◽  
Azizur Rahman
Keyword(s):  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Transmission Rate ◽  
Equilibrium Points ◽  
Rank Correlation ◽  
Dynamical Analysis ◽  
Model Parameters ◽  
Progression Rate ◽  
Double Dose ◽  
The Basic Reproduction Number

AbstractAlthough the availability of the measles vaccine, it is still epidemic in many countries globally, including Bangladesh. Eradication of measles needs to keep the basic reproduction number less than one $$(\mathrm{i}.\mathrm{e}. \, \, {\mathrm{R}}_{0}<1)$$ ( i . e . R 0 < 1 ) . This paper investigates a modified (SVEIR) measles compartmental model with double dose vaccination in Bangladesh to simulate the measles prevalence. We perform a dynamical analysis of the resulting system and find that the model contains two equilibrium points: a disease-free equilibrium and an endemic equilibrium. The disease will be died out if the basic reproduction number is less than one $$(\mathrm{i}.\mathrm{e}. \, \, {\mathrm{ R}}_{0}<1)$$ ( i . e . R 0 < 1 ) , and if greater than one $$(\mathrm{i}.\mathrm{e}. \, \, {\mathrm{R}}_{0}>1)$$ ( i . e . R 0 > 1 ) epidemic occurs. While using the Routh-Hurwitz criteria, the equilibria are found to be locally asymptotically stable under the former condition on $${\mathrm{R}}_{0}$$ R 0 . The partial rank correlation coefficients (PRCCs), a global sensitivity analysis method is used to compute $${\mathrm{R}}_{0}$$ R 0 and measles prevalence $$\left({\mathrm{I}}^{*}\right)$$ I ∗ with respect to the estimated and fitted model parameters. We found that the transmission rate $$(\upbeta )$$ ( β ) had the most significant influence on measles prevalence. Numerical simulations were carried out to commissions our analytical outcomes. These findings show that how progression rate, transmission rate and double dose vaccination rate affect the dynamics of measles prevalence. The information that we generate from this study may help government and public health professionals in making strategies to deal with the omissions of a measles outbreak and thus control and prevent an epidemic in Bangladesh.

scholarly journals Mathematical analysis of a within-host model of SARS-CoV-2

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Bhagya Jyoti Nath ◽  
Kaushik Dehingia ◽  
Vishnu Narayan Mishra ◽  
Yu-Ming Chu ◽  
Hemanta Kumar Sarmah
Keyword(s):  
Stability Analysis ◽  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Basic Reproduction Ratio ◽  
Viral Kinetics ◽  
Reproduction Ratio ◽  
Biological Implication ◽  
Infection Models ◽  
Kinetics Of ◽  
The Basic Reproduction Number

AbstractIn this paper, we have mathematically analyzed a within-host model of SARS-CoV-2 which is used by Li et al. in the paper “The within-host viral kinetics of SARS-CoV-2” published in (Math. Biosci. Eng. 17(4):2853–2861, 2020). Important properties of the model, like nonnegativity of solutions and their boundedness, are established. Also, we have calculated the basic reproduction number which is an important parameter in the infection models. From stability analysis of the model, it is found that stability of the biologically feasible steady states are determined by the basic reproduction number $(\chi _{0})$ ( χ 0 ) . Numerical simulations are done in order to substantiate analytical results. A biological implication from this study is that a COVID-19 patient with less than one basic reproduction ratio can automatically recover from the infection.

scholarly journals Threshold Dynamics of a Huanglongbing Model with Logistic Growth in Periodic Environments

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Jianping Wang ◽  
Shujing Gao ◽  
Yueli Luo ◽  
Dehui Xie
Keyword(s):  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Logistic Growth ◽  
Threshold Dynamics ◽  
Global Dynamics ◽  
Globally Asymptotically Stable ◽  
Linear Integral ◽  
The Impact ◽  
Disease Free ◽  
The Basic Reproduction Number

We analyze the impact of seasonal activity of psyllid on the dynamics of Huanglongbing (HLB) infection. A new model about HLB transmission with Logistic growth in psyllid insect vectors and periodic coefficients has been investigated. It is shown that the global dynamics are determined by the basic reproduction numberR0which is defined through the spectral radius of a linear integral operator. IfR0< 1, then the disease-free periodic solution is globally asymptotically stable and ifR0> 1, then the disease persists. Numerical values of parameters of the model are evaluated taken from the literatures. Furthermore, numerical simulations support our analytical conclusions and the sensitive analysis on the basic reproduction number to the changes of average and amplitude values of the recruitment function of citrus are shown. Finally, some useful comments on controlling the transmission of HLB are given.

scholarly journals Spatial dynamics of a diffusive SIRI model with distinct dispersal rates and heterogeneous environment

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Lian Duan ◽  
Lihong Huang ◽  
Chuangxia Huang
Keyword(s):  
Steady State ◽  
Basic Reproduction Number ◽  
Epidemic Model ◽  
Reproduction Number ◽  
Spatial Dynamics ◽  
Heterogeneous Environment ◽  
Threshold Parameter ◽  
Dispersal Rate ◽  
Siri Model ◽  
The Basic Reproduction Number

<p style='text-indent:20px;'>In this paper, we are concerned with the dynamics of a diffusive SIRI epidemic model with heterogeneous parameters and distinct dispersal rates for the susceptible and infected individuals. We first establish the basic properties of solutions to the model, and then identify the basic reproduction number <inline-formula><tex-math id="M1">\begin{document}$ \mathscr{R}_{0} $\end{document}</tex-math></inline-formula> which serves as a threshold parameter that predicts whether epidemics will persist or become globally extinct. Moreover, we study the asymptotic profiles of the positive steady state as the dispersal rate of the susceptible or infected individuals approaches zero. Our analytical results reveal that the epidemics can be extinct by limiting the movement of the susceptible individuals, and the infected individuals concentrate on certain points in some circumstances when limiting their mobility.</p>

scholarly journals Modeling Gender-Structured Wildlife Diseases with Harvesting: Chronic Wasting Disease as an Example

2012 ◽  
Vol 2012 ◽  
pp. 1-18 ◽  
Author(s):  
Mo'tassem Al-Arydah ◽  
Robert J. Smith ◽  
Frithjof Lutscher
Keyword(s):  
Basic Reproduction Number ◽  
Chronic Wasting Disease ◽  
Reproduction Number ◽  
Economic Consequences ◽  
Wildlife Diseases ◽  
Wasting Disease ◽  
Effective Strategies ◽  
Optimum Interval ◽  
The Stability ◽  
The Basic Reproduction Number

Chronic wasting disease (CWD) is a prion infectious disease that affects members of the deer family in North America. Concerns about the economic consequences of the presence of CWD have led management agencies to seek effective strategies to control CWD distribution and prevalence. Current mathematical models are either based on complex simulations or overly simplified compartmental models. We develop a mathematical model that includes gender structure to describe CWD in a logistically growing population. The model includes harvesting as a management strategy for the disease. We determine the stability conditions of the disease-free equilibrium for the model and calculate the basic reproduction number. We find an optimum interval of harvesting: with too little harvesting, the disease persists, whereas too much harvesting results in extinction of the population. A sensitivity analysis shows that the disease threshold is more sensitive to female than male harvesting and that harvesting has the greatest effect on the basic reproduction number. However, while harvesting may be a way to control CWD, the range of admissible harvesting rates may be very narrow, depending on other parameters.

scholarly journals Simple MSEIR Model for Measles Transmission

2019 ◽  
pp. 1-11
Author(s):  
Mojeeb Al-Rahman EL-Nor Osman ◽  
Appiagyei Ebenezer ◽  
Isaac Kwasi Adu
Keyword(s):  
Mathematical Model ◽  
Basic Reproduction Number ◽  
Recovery Rate ◽  
Birth Rate ◽  
Reproduction Number ◽  
Progression Rate ◽  
Asymptotically Stable ◽  
The Stability ◽  
Disease Free ◽  
The Basic Reproduction Number

In this paper, an Immunity-Susceptible-Exposed-Infectious-Recovery (MSEIR) mathematical model was used to study the dynamics of measles transmission. We discussed that there exist a disease-free and an endemic equilibria. We also discussed the stability of both disease-free and endemic equilibria.  The basic reproduction number  is obtained. If , then the measles will spread and persist in the population. If , then the disease will die out.  The disease was locally asymptotically stable if  and unstable if  . ALSO, WE PROVED THE GLOBAL STABILITY FOR THE DISEASE-FREE EQUILIBRIUM USING LASSALLE'S INVARIANCE PRINCIPLE OF Lyaponuv function. Furthermore, the endemic equilibrium was locally asymptotically stable if , under certain conditions. Numerical simulations were conducted to confirm our analytic results. Our findings were that, increasing the birth rate of humans, decreasing the progression rate, increasing the recovery rate and reducing the infectious rate can be useful in controlling and combating the measles.

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