Epicardial Ablation of Brugada Syndrome: from experimental to clinical

2021 ◽  
Author(s):  
sheilabi seeburun
Keyword(s):  
Brugada Syndrome ◽  
Epicardial Ablation

Hybrid thoracoscopic epicardial ablation of right ventricular outflow tract in patients with Brugada syndrome

Heart Rhythm ◽  
2019 ◽  
Vol 16 (6) ◽  
pp. 879-887 ◽  
Author(s):  
Francesca Salghetti ◽  
Carlo de Asmundis ◽  
Juan Sieira ◽  
Hugo Enrique Coutiño ◽  
Juan Pablo Abugattas ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Brugada Syndrome ◽  
Right Ventricular Outflow Tract ◽  
Ventricular Outflow Tract ◽  
Outflow Tract ◽  
Epicardial Ablation

Epicardial ablation eliminates ventricular arrhythmias in an experimental model of Brugada syndrome

Heart Rhythm ◽  
2009 ◽  
Vol 6 (5) ◽  
pp. 665-671 ◽  
Author(s):  
Hiroshi Morita ◽  
Douglas P. Zipes ◽  
Shiho T. Morita ◽  
John C. Lopshire ◽  
Jiashin Wu
Keyword(s):  
Experimental Model ◽  
Brugada Syndrome ◽  
Ventricular Arrhythmias ◽  
Epicardial Ablation

scholarly journals Epicardial Ablation in Brugada Syndrome

2020 ◽  
Vol 12 (3) ◽  
pp. 345-356
Author(s):  
Pier D. Lambiase ◽  
Rui Providência
Keyword(s):  
Brugada Syndrome ◽  
Epicardial Ablation

scholarly journals Brugada Syndrome: Progress in Genetics, Risk Stratification and Management

2019 ◽  
Vol 8 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Jorge Romero ◽  
Dan L Li ◽  
Ricardo Avendano ◽  
Juan Carlos Diaz ◽  
Roderick Tung ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Risk Stratification ◽  
Brugada Syndrome ◽  
Cardiac Death ◽  
Molecular Mechanisms ◽  
Asian Countries ◽  
Epicardial Ablation ◽  
Future Studies ◽  
Common Causes ◽  
Southeast Asian Countries

Brugada syndrome (BrS) is one of the most common causes of sudden cardiac death in normal structural heart individuals. First characterised in 1992, the global prevalence of BrS is unclear, with estimates placing it at around 0.05% and presenting most frequently in southeast Asian countries. This review aims to summarise the development in the understanding of BrS and, importantly, progress in its management, underpinned by knowledge regarding its genetics and molecular mechanisms. It also provides update on risk stratification and promising new therapies for BrS, including epicardial ablation. Future studies are required to increase understanding of the pathogenesis of this disease and to guide clinical practice.

Predictors of success for Brugada syndrome epicardial ablation

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S Grossi ◽  
F Bianchi ◽  
A Blandino ◽  
A Sibona Masi ◽  
C Pintor ◽  
...  
Keyword(s):  
Brugada Syndrome ◽  
Low Voltage ◽  
Low Frequency ◽  
Right Ventricular Outflow Tract ◽  
Ventricular Outflow Tract ◽  
Control Mode ◽  
Epicardial Ablation ◽  
Single Procedure ◽  
Risk Patients

Abstract   Epicardial right ventricular outflow tract (RVOT) ablation has been described for the treatement of Brugada syndrome (BrS) high risk patients. Purpose Success evaluation of epicardial ablation for BrS. Methods Type 1 ECG was defined as spontaneous if recorded in absence of drugs and/or specific conditions. BrS patients were scheduled for ablation if presented at least one of: spontaneous type 1 ECG, syncope, ventricular arrhythmias (VA). Programmed electrical stimulation (PES) was performed (2 extrastimuli, 2 sites) in basal conditions and after ajmaline infusion. Epicardial subxifoid access and electroanatomical endo-epicardial maps were obtained during sinus rhythm. Delayed fragmented/low-frequency, low-voltage electrograms (EGM) were targeted: substrate area measured in basal conditions and after ajmaline. Epicardial ablation Radiofrequency (RF) was delivered (50 W power control mode) till complete elimination of targeted EGM and BrS-ECG pattern after ajmaline. Eventually PES repeated: if positive a repeated PES scheduled at follow-up (fu). Success was defined as absence of type 1 ECG either spontaneous or with ajmaline challenge at 3 month. Recurrences were scheduled to redo ablation. Results 55 patients were submitted to 58 ablation procedures. 38 spontaneous type 1 ECG: 18 symptomatic for syncope/polimorphic VT/VF or appropriate ICD shock; 13 had VA induction at PES. 4 patients with ajmaline-type 1 ECG had VA induction. 36% of the symptomatic patients and 26% of asymptomatic had PES-VA induction. In all patients abnormal EGM area (cm2) was detected in epicardial RVOT (table 1). Acute success: No patient had ECG type 1 with ajmaline. 5 patients had PES induction of VA. Complications: 1 cardiac tamponade, 16 mild pericarditis. At FU of 1,1±0,6 yrs no patient had spontaneous ECG type 1 nor arrhythmic events. 50 had negative ajmaline challenge (90% success rate after single procedure), 3 underwent redo: 2 had negative ajmaline challenge at FU, 1 had persistence type 1-ajmaline induction; 2 are scheduled for redo. No patient had VT induction at PES. Multivariate analysis: Single procedure success was not related either to history (symptoms, VA, type 1 ECG) or to procedural findings (PES results, substrate area). Conclusion Epicardial substrate ablation was safe end effective in BrS. No clinical or procedural findings were related to success Funding Acknowledgement Type of funding source: None

scholarly journals First case of epicardial ablation to coexistent J waves in the inferior leads in a patient with clinical diagnosis of Brugada syndrome

2015 ◽  
Vol 1 (2) ◽  
pp. 82-84 ◽  
Author(s):  
Shingo Maeda ◽  
Yasuhiro Yokoyama ◽  
William W. Chik ◽  
Kyoko Soejima ◽  
Kenzo Hirao
Keyword(s):  
Clinical Diagnosis ◽  
Brugada Syndrome ◽  
Epicardial Ablation ◽  
First Case

scholarly journals Epicardial ablation for prevention of ventricular fibrillation in a patient with Brugada Syndrome

2014 ◽  
Vol 33 (5) ◽  
pp. 305.e1-305.e7 ◽  
Author(s):  
Nuno Cortez-Dias ◽  
Rui Plácido ◽  
Liliana Marta ◽  
Ana Bernardes ◽  
Sílvia Sobral ◽  
...  
Keyword(s):  
Ventricular Fibrillation ◽  
Brugada Syndrome ◽  
Epicardial Ablation
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