scholarly journals Statistical Optimization of Sertraline Hydrochloride Loaded Solid Lipid Nanoparticles Using Box-Behnken Design

2018 ◽  
Vol 11 (3) ◽  
pp. 206-217
Author(s):  
Vaishali M. Gambhire ◽  
Kishor N. Gujar ◽  
Varsharani D. Patil
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Statistical Optimization ◽  
Box Behnken Design ◽  
Solid Lipid ◽  
Sertraline Hydrochloride

Optimization of methazolamide-loaded solid lipid nanoparticles for ophthalmic delivery using Box–Behnken design

2014 ◽  
Vol 24 (3) ◽  
pp. 171-181 ◽  
Author(s):  
Fengzhen Wang ◽  
Li Chen ◽  
Sunmin Jiang ◽  
Jun He ◽  
Xiumei Zhang ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Box Behnken Design ◽  
Solid Lipid ◽  
Ophthalmic Delivery

scholarly journals Preclinical Screening of Antidepressant Activity of Formulated Sertraline Hydrochloride-Loaded Solid Lipid Nanoparticles in Rats

2021 ◽  
pp. 134-138
Author(s):  
Sachin R. Hangargekar ◽  
Pradeep K. Mohanty ◽  
Janki Prasad Rai
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Lipid Nanoparticles ◽  
Antidepressant Effect ◽  
Control Group ◽  
Solid Lipid ◽  
Test Formulation ◽  
Sertraline Hydrochloride ◽  
Swimming Test

Objective: The main goal of our study was to investigate the antidepressant activity of Formulated Sertraline hydrochloride-loaded Solid Lipid Nanoparticles (SLNPs) by using a rat forced swimming test (FST) and tail suspension test (TST). Materials and Methods: Animals were divided into three groups, consisting of six rats in each group. Out of these,  one  group  served  as  control  that received distilled water, second group was standard received Sertraline  HCl  (20  mg/kg  intranasal)  and  third  group  was  received  test formulation (SLNPs 50 mg/kg intranasal). To assess the effect of SLNPs on immobility activity through FST and TST were used to take as a measure of antidepressant activity. Results: SLNPs reduced the immobility duration in TST as well as in FST. In both methods, there was a statistical significant decrease in immobility of SLNPs group when compared to the control group. Conclusion: The results suggested that SLNPs produced significant antidepressant effect in rats which was comparable with control group and standard Sertraline HCl group animals.

scholarly journals Preparation and Characterization of Solid Lipid Nanoparticles of Cinnacalcet HCl

2021 ◽  
pp. 173-184
Author(s):  
Sudhanshu Bhusan Routray ◽  
Ch. Niranjan Patra
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Aqueous Suspension ◽  
Lipid Nanoparticles ◽  
Poloxamer 407 ◽  
Solid Lipid Nanoparticle ◽  
Box Behnken Design ◽  
Solid Lipid ◽  
Soya Lecithin ◽  
Lipid Nanoparticle

Objective: The objective of the present research is to formulate solid lipid nanoparticles of cinnacalcet HCl to improve its oral bioavailability. Methods: Cinnacalcet hydrochloride exhibits poor oral bioavailability of 20 to 25 % because of low aqueous solubility and first pass metabolism. The formulations were optimised using Box-Behnken Design. Solid lipid nanoparticles formulation was prepared using hot homogenization and ultra sonication method. Results and Discussion: Precirol ATO 05, Soya lecithin and poloxamer 407 were selected as lipid, surfactant and co-surfactant respectively. For optimistaion the desirable goal was fixed for various responses entrapment efficiency, particle size and (time taken for diffusion of 85% drug) T85%. The optimized single dose of solid lipid nanoparticle obtained using box behnken design consisting of 30 mg of cinnacalcet HCl, 200 mg of precirol ATO 05, 250 mg of soya lecithin and 0.2% w/v of poloxamer. 407. The pharmacokinetic study revealed that optimized formulation was found to increase the oral bioavailability nearly 3 times compared to aqueous suspension of pure drug. Conclusion: Thus optimized solid lipid nanoparticle explicated the potential of lipid-based nanoparticles as a potential carrier in improving the oral delivery.

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