scholarly journals Photolytic Irradiation of Pharmaceutical Compound 2 (-4 thaizolyl) benzimidazole

2020 ◽  
Vol 13 (3) ◽  
pp. 99-106
Author(s):  
Meena Chourey
Keyword(s):  
Methyl Orange ◽  
Thin Layer ◽  
Uv Light ◽  
Mercury Vapor ◽  
Photochemical Reactions ◽  
Neutral Medium ◽  
Chromatography Method ◽  
Pharmaceutical Properties ◽  
Layer Chromatography ◽  
Mercury Vapor Lamp

Photolytic irradiation of 2(-4 thiazolyl) benzimidazole in acidic and neutral medium using benzophenone (methyl orange) as sensitizer .Photochemical reactions depend on the source of the reaction. for example Sunlight, UV light and visible light. 2-(-4 thiazoly) benzimidazole(2gm powder) was dissolved in dried and distilled ethyl alcohol (C2H5OH) 200 ml and add 0.01gm sensitizer. The solution mixture was irradiated in presence of 125w and 250 w mercury vapor lamp for around 40 to50 hrs. The progress of the reaction mixture was observed at regular intervals from Thin layer chromatography method every10 hrs. After 41 and 55 hrs two new spots appeared on the plate of TLC. At the end of the reaction two products were found. This products show many pharmaceutical properties like primarily in treatment to control the stomach warm mold and fungal diseases infection, also widely used in (thiabendezole medicine), anti parasitic medicine for treatment of roundworm, hookworm and helminthes

scholarly journals DETERMINATION OF 10-GINGEROL IN INDIAN GINGER BY VALIDATED HPTLC METHOD OF SAMPLES COLLECTED ACROSS SUBCONTINENT OF INDIA

2016 ◽  
Vol 8 (12) ◽  
pp. 190
Author(s):  
Kamran Ashraf ◽  
Syed Adnan Ali Shah ◽  
Mohd Mujeeb
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Limit Of Detection ◽  
Limit Of Quantification ◽  
Chromatography Method ◽  
Aluminum Plates ◽  
Layer Chromatography ◽  
Hptlc Method

<p><strong>Objective: </strong>A simple, sensitive, precise, and accurate stability indicating HPTLC (high-performance thin-layer chromatography) method for analysis of 10-gingerol in ginger has been developed and validated as perICH guidelines.</p><p><strong>Methods: </strong>The separation was achieved on TLC (thin layer chromatography) aluminum plates pre-coated with silica gel 60F<sub>254</sub> using n-hexane: ethyl acetate 55:45 (%, v/v) as a mobile phase. Densitometric analysis was performed at 569 nm.</p><p><strong>Results: </strong>This system was found to have a compact spot of 10-gingerol at <em>R</em><sub>F</sub> value of 0.57±0.03. For the proposed procedure, linearity (<em>r</em><sup>2</sup> = 0.998±0.02), limit of detection (18ng/spot), limit of quantification (42 ng/spot), recovery (ranging from 98.35%–100.68%), were found to be satisfactory.</p><p><strong>Conclusion: </strong>Statistical analysis reveals that the content of 10-gingerol in different geographical region varied significantly. The highest and lowest concentration of 10-gingerol in ginger was found to be present in a sample of Patna, Lucknow and Surat respectively which inferred that the variety of ginger found in Patna, Lucknow are much superior to other regions of India.</p>

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