scholarly journals 8-Anilino-1-naphthalenesulfonate (ANS) as a probe for Poly(vinyl alcohol)(PVA) swelling

2020 ◽  
Vol 13 (2) ◽  
pp. 54-60
Author(s):  
Janbee Shaik ◽  
Anitha C Kumar
Keyword(s):  
Drug Delivery ◽  
Fluorescent Probe ◽  
Fluorescence Intensity ◽  
Vinyl Alcohol ◽  
Biomedical Applications ◽  
Poly Vinyl Alcohol ◽  
Hydrophilic Polymer ◽  
Swelling Behaviour ◽  
Swelling Properties ◽  
Drug Delivery Applications

Poly (vinyl alcohol) (PVA) is a hydrophilic polymer developed for biomedical applications. Swelling properties of PVA gels is very important for its drug delivery applications. There are many ways to study the swelling behaviour. Here we are proposing a fluorescent study by using 8-anilino-1-naphthalenesulfonate (ANS) as an extrinsic fluorescent probe. When ANS incorporated PVA films are allowed to swell in water, there is a loss of fluorescence intensity at 453 nm and there is a new peak at 500 nm. Thus, ANS is proposed as a fluorescent probe for the sensing of hydration of PVA.

Synthesis of novel poly (vinyl alcohol)/tamarind gum/bentonite-based composite films for drug delivery applications

2021 ◽  
Vol 613 ◽  
pp. 126043
Author(s):  
Dilshad Qureshi ◽  
Kiran Prava Behera ◽  
Debashish Mohanty ◽  
Santosh K. Mahapatra ◽  
Sarika Verma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Vinyl Alcohol ◽  
Composite Films ◽  
Poly Vinyl Alcohol ◽  
Drug Delivery Applications

Semi-interpenetrating polymeric networks based on poly(dimethylsiloxane)-chitosan-poly(vinyl alcohol) crosslinked with genipin with possible use in biomedical applications

2021 ◽  
Vol 56 (9) ◽  
pp. 5936-5955
Author(s):  
J. A. Benítez-Martínez ◽  
I. M. Garnica-Palafox ◽  
G. Vázquez-Victorio ◽  
M. Hautefeuille ◽  
F. M. Sánchez-Arévalo
Keyword(s):  
Vinyl Alcohol ◽  
Biomedical Applications ◽  
Poly Vinyl Alcohol ◽  
Polymeric Networks ◽  
Interpenetrating Polymeric Networks

scholarly journals The Interplay between Drug and Sorbitol Contents Determines the Mechanical and Swelling Properties of Potential Rice Starch Films for Buccal Drug Delivery

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 578
Author(s):  
Bilal Harieth Alrimawi ◽  
May Yee Chan ◽  
Xin Yue Ooi ◽  
Siok-Yee Chan ◽  
Choon Fu Goh
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Physicochemical Characteristics ◽  
Rice Starch ◽  
Swelling Behaviour ◽  
Swelling Properties ◽  
Buccal Drug Delivery ◽  
Swelling Characteristics ◽  
Starch Films ◽  
Film Development

Rice starch is a promising biomaterial for thin film development in buccal drug delivery, but the plasticisation and antiplasticisation phenomena from both plasticisers and drugs on the performance of rice starch films are not well understood. This study aims to elucidate the competing effects of sorbitol (plasticiser) and drug (antiplasticiser) on the physicochemical characteristics of rice starch films containing low paracetamol content. Rice starch films were prepared with different sorbitol (10, 20 and 30% w/w) and paracetamol contents (0, 1 and 2% w/w) using the film casting method and were characterised especially for drug release, swelling and mechanical properties. Sorbitol showed a typical plasticising effect on the control rice starch films by increasing film flexibility and by reducing swelling behaviour. The presence of drugs, however, modified both the mechanical and swelling properties by exerting an antiplasticisation effect. This antiplasticisation action was found to be significant at a low sorbitol level or a high drug content. FTIR investigations supported the antiplasticisation action of paracetamol through the disturbance of sorbitol–starch interactions. Despite this difference, an immediate drug release was generally obtained. This study highlights the interplay between plasticiser and drug in influencing the mechanical and swelling characteristics of rice starch films at varying concentrations.

Sign in / Sign up

Export Citation Format

Share Document