scholarly journals Novel Synthesis and Pharmaceutical Impurities of AntiHypertensive Drugs: A Review

2020 ◽  
Vol 13 (2) ◽  
pp. 18-28
Author(s):  
Anshul Kumar ◽  
Rajnish Kumar ◽  
Sweety Saini
Keyword(s):  
Myocardial Infarction ◽  
Antihypertensive Drugs ◽  
The Novel ◽  
Human Beings ◽  
Novel Synthesis ◽  
Pharmaceutical Impurities

hypertension is the disease which mainly occurred due to the lifestyle which is very abnormal adopted by today’s human beings. Therapy to this disease led to the prevention disease such as myocardial infarction and stroke which is very common. 13The motive behind the study is to gain the interest of the reviewer to understand the novel impurities of the hypertensive drugs and the intermediate that occur during the synthesis which will to understand the purity of the of the API formation which will conclude through the impurities formation.

Moralitas dalam Novel Negeri di Ujung Tanduk Karya Tere Liye

2018 ◽  
Vol 1 (1) ◽  
pp. 154-173
Author(s):  
Muhtadin Muhtadin ◽  
Sugi Murniasih
Keyword(s):  
Research Method ◽  
Self Esteem ◽  
The Novel ◽  
Human Beings ◽  
Human Relationships ◽  
Mutual Help ◽  
Analysis Techniques ◽  
Self Confidence ◽  
Record Data ◽  
Morality Literature

The objective of this research was to describes the morality contained in the novel Affairs at the Negeri di Ujung Tanduk the works Tere Liye. The research method used content analysis. The data in this research is a sentence containing the moral values ​​contained by the novel of the State at Ujung Tanduk Karya Tere Liye. Technique of collecting data using documentation technique and record. Data analysis techniques with steps: data reduction, data tabulation and coding, interpretation, classification, and conclusion. The result of the research shows that morality in Tere Liye Negeri di Ujung Tanduk novel is: first, human relationships with other human beings in the form of self existence, self esteem, self confidence, fear, death, longing, resentment, loneliness, maintaining the sanctity of greed, developing courage, honesty, hard work, patient, resilient, cheerful, steadfast, open, visionary, independent, brave, courageous, optimistic, envy, hypocritical, reflective, responsible, principle, confident, disciplined , and voracious. Second, human relationships with other humans or social and nature in the form of cooperation, acquaintance, hypocrisy, caring, hypocrisy, caring, friendship, smile, mutual help, and betrayal. Third human relationships in the form of God's menthidising and avoiding shirk, piety and pleading with prayers, prayers performed by human beings, as an awareness that everything in this universe belongs to God. Keywords: morality, literature, novel

scholarly journals Critiquing Anthropocentrism in Henry Ole Kulet’s Vanishing Herds

2019 ◽  
Vol 3 (1) ◽  
pp. 52-55
Author(s):  
Pushpa Raj Jaishi
Keyword(s):  
Environmental Degradation ◽  
Physical Environment ◽  
Critical Issue ◽  
The Novel ◽  
Contemporary Society ◽  
Human Beings ◽  
East African ◽  
To Come

Vanishing Herds (2011) is Henry Ole Kulet’s novel that hovers around the ecological depletion caused by the anthropocentric attitude of the human beings. Set in the East African Savannah, the novel grapples with the critical issue of anthropogenic environmental degradation. The novel is based on the tribulations of a young Maasai couple –Kedoki and Norpisia whose epic journey through the wilderness provides a window through which the destruction of the physical environment can be viewed. Additionally, the text catalogues the challenges faced by a pastoralist community’s attempt to come to terms with the socio-economic realities of a fast-evolving contemporary society. The paper is an attempt to study this novel under the surveillance of green lens and throw light on the ecological destruction especially the clearing of the forest by human self centered endeavors and to critique the anthropocentric attitude of the human beings that render the environment at the verge of destruction.

scholarly journals Frog Metaphors in Mo Yan’s Novel 蛙 /UA55/ (Frog): A Cognitive Perspective

MANUSYA ◽  
2017 ◽  
Vol 20 (2) ◽  
pp. 122-153
Author(s):  
Yao Siqi
Keyword(s):  
The Novel ◽  
Human Beings ◽  
Mo Yan ◽  
Cognitive Approach ◽  
One Child Policy ◽  
Child Policy ◽  
Past Half Century ◽  
Metaphor Theory ◽  
George Lakoff ◽  
Chinese Author

《蛙》/ua55/ (frog) by the Nobel Prize winning Chinese author Mo Yan describes China’s changing its highly controversial one - child policy and system of forced abortions over the past half-century. Frog metaphors are omnipresent throughout the novel. The present study aims to investigate these metaphors within the framework of George Lakoff and Mark Johnson’s (1980) Conceptual Metaphor Theory (CMT) and the “GREAT CHAIN OF BEING” system of George Lakoff and Mark Turner (1989) to deepen our understanding of their nature and manifestations. Zoltán Kövecses’s (2002) “HUMAN BEINGS ARE ANIMALS” and “ANIMALS ARE HUMAN BEINGS” were also considered as cognitive metaphorical models. Moreover, the viewpoint of “phonetic metaphor” initially proposed by Ivan Fónagy (1999) was also taken into account. Results were that in Mo Yan’s work, the frog plays an essential role in the conceptualizing conventional views of certain areas in China. The analysis demonstrates how a cognitive approach offers an effective way to explore the cognitive basis of the text’s view on the complex relationship between the basic human rights and the dilemmas of living in a repressive society. This paper also hopes to make a certain contribution to comprehending frog metaphors in terms of more clearly delineated concepts and ideology reflecting China’s real society of a one-child policy and its traditional counter - policy notion.

"A Dismal Swamp": Darwin, Design, and Evolution in Our Mutual Friend

1994 ◽  
Vol 49 (1) ◽  
pp. 50-74 ◽  
Author(s):  
Howard W. Fulweiler
Keyword(s):  
The Novel ◽  
Human Beings ◽  
Origin Of Species ◽  
Victorian Fiction ◽  
Dismal Swamp ◽  
Human World ◽  
Laissez Faire ◽  
Our Mutual Friend ◽  
The Relationship ◽  
Mutual Friend

Our Mutual Friend, published just six years after Darwin's The Origin of Species, is structured on a Darwinian pattern. As its title hints, the novel is an account of the mutual-though hidden-relations of its characters, a fictional world of individuals seeking their own advantage, a "dismal swamp" of "crawling, creeping, fluttering, and buzzing creatures." The relationship between the two works is quite direct in light of the large number of reviews on science, evolution, and The Origin from 1859 through the early 1860s in Dicken's magazine, All the Year Round. Given the laissez-faire origin of the Origin, Dicken's use of it in a book directed against laissez-faire economics is ironic. Important Darwinian themes in the novel are predation, mutual relationships, chance, and, especially, inheritance, a central issue in both Victorian fiction and in The Origin of Species. The novel asks whether predatory self-seeking or generosity should be the desired inheritance for human beings. The victory of generosity is symbolized by a dying child's "willing" his inheritance of a toy Noah's Ark, "all the Creation," to another child. Our Mutual Friend is saturated with the motifs of Darwinian biology, therefore, to display their inadequacy. Although Dickens made use of the explanatory powers of natural selection and remained sympathetic to science, the novel transcends and opposes its Darwinian structure in order to project a teleological and designed evolution in the human world toward a moral community of responsible men and women.

Abstract P227: Circulating and Dietary Linoleic Acid and Prevalent Diabetes in Post-Myocardial Infarction Patients

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Kamalita Pertiwi ◽  
Anne J Wanders ◽  
Peter L Zock ◽  
Marjolein C Harbers ◽  
Johanna M Geleijnse
Keyword(s):  
Myocardial Infarction ◽  
Linoleic Acid ◽  
Linear Models ◽  
Antihypertensive Drugs ◽  
Plasma Cholesterol ◽  
Epidemiological Studies ◽  
Dietary Factors ◽  
Metabolic Parameters ◽  
Cross Sectional ◽  
Total Fatty Acids

Background: Circulating linoleic acid 18:2n-6 (LA) has been considered to reflect LA intake, but its utility as a dietary biomarker could be affected by metabolism. Objective: To study the associations of plasma and dietary LA with T2D prevalence in drug-treated patients with a history of myocardial infarction (MI). Methods: Cross-sectional analysis of baseline data in 4,072 Dutch post-MI patients of the Alpha Omega Cohort. Circulating LA (as % of total fatty acids) was assessed in plasma cholesterol esters (CE) in the total cohort and in plasma phospholipids (PL) in a random subset of 833 patients. LA intake was assessed by a 203-item validated food frequency questionnaire. Prevalence ratios of T2D and associations with metabolic parameters were estimated in plasma and dietary LA quintiles using multivariable generalized linear models adjusted for demographic, lifestyle and dietary factors. Results: Patients were on average 69 years old, 79% was male and 77% were overweight or obese. Most patients used statins (86%), antihypertensive drugs (90%) and antiplatelet drugs (84%). A total of 813 patients (20%) had T2D. Mean LA intake (±SD) was 5.7±2.2 energy%, and circulating LA was 49.9±5.0% in CE and 18.7±3.0% in PL. Spearman’s correlations of dietary LA with circulating LA in CE and PL were 0.16 and 0.10, respectively. Higher plasma LA, but not dietary LA, was significantly associated with a lower diabetes prevalence (Table 1). BMI (β= -0.07, p<0.001), log non-fasting triglycerides (β= -0.01, p<0.001), log non-fasting glucose (β= -0.01, p<0.001), and log alcohol intake (β= -0.03, p<0.001) were significantly associated with circulating LA in plasma CE. Similar associations were found for LA in plasma PL. Dietary LA was not significantly associated with T2D prevalence and metabolic parameters (all p>0.05). Conclusions: Circulating LA may reflect both LA intake and metabolic state in drug-treated post-MI patients. This bears restrictions for its use as a biomarker of dietary LA intake in epidemiological studies.

From Decline of the West to Dawn of Day

Janus Head ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 53-66
Author(s):  
Hub Zwart ◽  
Keyword(s):  
Artificial Intelligence ◽  
Computer Science ◽  
Science And Religion ◽  
Natural Sciences ◽  
The Novel ◽  
Human Beings ◽  
Cultural Significance ◽  
Religion And Science ◽  
The West ◽  
Smart Technologies

This paper subjects Dan Brown’s most recent novel Origin to a philosophical reading. Origin is regarded as a literary window into contemporary technoscience, inviting us to explore its transformative momentum and disruptive impact, focusing on the cultural significance of artificial intelligence and computer science: on the way in which established world-views are challenged by the incessant wave of scientific discoveries made possible by super-computation. While initially focusing on the tension between science and religion, the novel’s attention gradually shifts to the increased dependence of human beings on smart technologies and artificial (or even “synthetic”) intelligence. Origin’s message, I will argue, reverberates with Oswald Spengler’s The Decline of the West, which aims to outline a morphology of world civilizations. Although the novel starts with a series of oppositions, most notably between religion and science, the eventual tendency is towards convergence, synthesis and sublation, exemplified by Sagrada Família as a monumental symptom of this transition. Three instances of convergence will be highlighted, namely the convergence between science and religion, between humanity and technology and between the natural sciences and the humanities.

Novel synthesis of 1,5-disubstituted-1,2,3-triazolines catalysed by Zepto magnetic microspheres under the influence of a rotating magnetic field

2019 ◽  
Vol 97 (3) ◽  
pp. 163-168 ◽  
Author(s):  
Priyanka Sharma ◽  
Srinivasu V. Vallabhapurapu ◽  
Wei H. Ho ◽  
Nanjundaswamy M. Hemmaragala
Keyword(s):  
Magnetic Field ◽  
Magnetic Force ◽  
Rotating Magnetic Field ◽  
Magnetic Microspheres ◽  
The Novel ◽  
Aryl Azides ◽  
Alkyl Aryl ◽  
Novel Synthesis ◽  
Bead Diameter ◽  
Magnetic Poles

The novel reactor has been designed to perform chemical reactions under the influence of a magnetic field generated by alternating magnetic poles as a function of time. The system was successfully employed to synthesize a series of 1,5-disubstituted-1,2,3-triazolines via the regioselective [3 + 2] cycloaddition reactions between alkyl/aryl azides and nitroolefins catalysed by Zepto (para magnetic ultra-blue carboxy functionalized) microspheres (bead diameter 2.5 μm). All of the reactions went smoothly without any adverse effect on nitro, cyano, thienyl, hydroxy, halogens, and ether functions at 25 ± 2 °C and afforded 82%–99% pure products at a magnetic field of 18.99 mT and an exposure time of 180–240 min. The influence of the magnetic force exerted on the magnetic materials was found to enhance the catalytic activity of microspheres. The catalyst could easily be separated by simple centrifugation, which could be reused for at least 15 runs with no loss in activity.

scholarly journals ECO CRITICISM IN THE HUNGRY TIDE

2017 ◽  
Vol 4 (1) ◽  
pp. 53-54
Author(s):  
Karthikeyan P
Keyword(s):  
Marine Mammals ◽  
Heavy Rain ◽  
Literary Text ◽  
Poor People ◽  
The Novel ◽  
Human Beings ◽  
Indian American ◽  
Marine Habitats ◽  
Literature And Environment ◽  
Local Fisherman

The novel speaks about the efforts taken by Piyali Roy, an Indian American biologist to make a study on marine mammals, especially on Irrawaddy dolphins.The novel is set in Sundarbans. Piya arrives at Sundarbans which is considered by her as a suitable place for carrying out her study. She lands on an island in Sunderbans and gets acquainted with an inhabitant of that place named Fokir. He remains to be a guide for her and instructs her about the marine habitats. Fokir being a resident of that place, he knows about the tides occurrence in the seas and the perils. Though he knows these, to the dismay of the readers, Fokir dies when a storm breaks out followed by heavy rain and powerful and devouring tides. As ideas given by Fokir could be the sources for decades of ‘research’,with the sponsorship of Nilima and involvement of local fisherman, Piya starts an institution in the memory of Fokir. The novel deals with the dislocation of people due to tide. Tide causes great havoc to the life and property of the inhabitants of the islands in Sunderbans. The poor people who have become victims of natural catastrophe suffer from hunger. I would like to bring out the human environmental relationship in the novel. Human beings depend on nature and environment. Eco Criticism on this novel helps to evaluate this literary text in the literature and environment perspective.

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