scholarly journals Design and Evaluation Of Metronidazole Vaginal Tablet For Once Daily Administration

2019 ◽  
Vol 12 (04) ◽  
pp. 244-265
Author(s):  
Krishnaveni Manubolu ◽  
K. Sruthi ◽  
M. Sreenivasulu
Keyword(s):  
Daily Administration ◽  
Once Daily ◽  
Vaginal Tablet

Once-Daily Administration of Antiretrovirals

2003 ◽  
Vol 42 (14) ◽  
pp. 1179-1191 ◽  
Author(s):  
Anne-Marie Taburet ◽  
Sabine Paci-Bonaventure ◽  
Gilles Peytavin ◽  
Jean-Michel Molina
Keyword(s):  
Daily Administration ◽  
Once Daily

Follicle size and reproductive hormone profiles during a post-weaning altrenogest treatment in primiparous sows

2015 ◽  
Vol 27 (2) ◽  
pp. 304 ◽  
Author(s):  
J. J. J. van Leeuwen ◽  
M. R. T. M. Martens ◽  
J. Jourquin ◽  
M. A. Driancourt ◽  
A. Wagner ◽  
...  
Keyword(s):  
High Frequency ◽  
Fold Increase ◽  
High Amplitude ◽  
Daily Administration ◽  
Reproductive Hormone ◽  
Diurnal Pattern ◽  
Once Daily ◽  
Follicular Wave ◽  
Follicle Size ◽  
Low Amplitude

This study investigated the endocrine background of follicle size changes during post-weaning altrenogest treatment. altrenogest-treated sows received a 20-mg dosage daily at 8.00 a.m. from Day –1 to Day 14 after weaning. On Day –1, only 3/13 altrenogest-treated sows showed LH pulses compared with 8/8 control sows (P = 0.001). On Day 0, control sows showed a typical high frequency–low amplitude LH pattern, indicative for recruitment of oestrogenic follicles. In altrenogest-treated animals on Day 0, half of the sows showed high frequency–high amplitude pulses from 4–5 h after weaning. In altrenogest-treated sows, average follicle size increased from 3.1 ± 0.5 mm on Day 0 to 4.4 ± 0.6 mm on Day 5, then decreased to 3.7 ± 0.5 mm on Day 7 and stabilised thereafter. FSH and oestradiol (E2) concentrations showed a distinct diurnal pattern; high at 7.00 a.m. and low at 3.00 p.m. E2 concentrations (7.00 a.m.) showed a 2.5-fold increase from Day –1 to Day 2, and subsequently a 2-fold decline to reach a plateau at Day 8. FSH concentrations reached maximum levels by Day 5 and slowly declined afterwards. In conclusion, once-daily administration of altrenogest starting one day before weaning delays the weaning-induced increase in LH pulses. Although FSH and follicle size increase until Day 5 after weaning, follicle E2 production already decreased from Day 2 after weaning. Post-weaning altrenogest treatment thus results in a follicular wave of follicles that lose oestrogenic competence at Day 2 after weaning, presumably related to the changed LH dynamics during altrenogest treatment.

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