scholarly journals The Role of Electrospun Fiber Scaffolds in Stem Cell Therapy for Skin Tissue Regeneration

Med One ◽  
2019 ◽  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Tissue Regeneration ◽  
Stem Cell Therapy ◽  
Electrospun Fiber ◽  
Skin Tissue ◽  
Fiber Scaffolds

scholarly journals Magnetic Resonance Imaging of Myocardial Function Following Intracoronary and Intramyocardial Stem Cell Injection

2017 ◽  
Vol 2 (2) ◽  
pp. 112-116
Author(s):  
András Mester ◽  
Balázs Oltean-Péter ◽  
Ioana Rodean ◽  
Diana Opincariu ◽  
Alexandra Stănescu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Stem Cell ◽  
Magnetic Resonance ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Imaging Method ◽  
Resonance Imaging ◽  
Cell Based Therapy

AbstractStem cell-based therapy is a new therapeutic option that can be used in patients with cardiac diseases caused by myocardial injury. Cardiac magnetic resonance imaging (MRI) is a new noninvasive imaging method with an increasingly widespread indication. The aim of this review was to evaluate the role of cardiac MRI in patients with myocardial infarction undergoing stem cell therapy. We studied the role of MRI in the assessment of myocardial viability, stem cell tracking, assessment of cell survival rate, and monitoring of the long-term effects of stem cell therapy. Based on the current knowledge in this field, this noninvasive, in vivo cardiac imaging technique has a large indication in this group of patients and plays an important role in all stages of stem cell therapy, from the indication to the long-term follow-up of patients.

Role of stem cell therapy in neurosciences

2022 ◽  
pp. 163-179
Author(s):  
Shilpa Sharma ◽  
Madhan Jeyaraman ◽  
Sathish Muthu
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy

scholarly journals A novel lncRNA LNC_000052 leads to the dysfunction of osteoporotic BMSCs via the miR-96-5p–PIK3R1 axis

2020 ◽  
Vol 11 (9) ◽  
Author(s):  
Mingyang Li ◽  
Rong Cong ◽  
Liyu Yang ◽  
Lei Yang ◽  
Yiqi Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Tissue Regeneration ◽  
Stem Cell Therapy ◽  
Therapeutic Effects ◽  
The Novel ◽  
Akt Signaling Pathway ◽  
Physiological Conditions ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract Bone marrow-derived mesenchymal stem cells (BMSCs) in postmenopausal osteoporosis models exhibit loss of viability and multipotency. Identification of the differentially expressed RNAs in osteoporotic BMSCs could reveal the mechanisms underlying BMSC dysfunction under physiological conditions, which might improve stem cell therapy and tissue regeneration. In this study, we performed high-throughput RNA sequencing and showed that the novel long non-coding RNA (lncRNA) LNC_000052 and its co-expressed mRNA PIK3R1 were upregulated in osteoporotic BMSCs. Knockdown of LNC_000052 could promote BMSC proliferation, migration, osteogenesis, and inhibit apoptosis via the PI3K/Akt signaling pathway. We found that both LNC_000052 and PIK3R1 shared a miRNA target, miR-96-5p, which was downregulated in osteoporotic BMSCs. Their binding sites were confirmed by dual-luciferase assays. Downregulation of miR-96-5p could restrain the effects of LNC_000052 knockdown while upregulation of miR-96-5p together with LNC_000052 knockdown could improve the therapeutic effects of BMSCs. In summary, the LNC_000052–miR-96-5p–PIK3R1 axis led to dysfunction of osteoporotic BMSCs and might be a novel therapeutic target for stem cell therapy and tissue regeneration.

scholarly journals Role of Nanodiamonds in Drug Delivery and Stem Cell Therapy

2016 ◽  
Vol 14 (3) ◽  
pp. 130-141 ◽  
Author(s):  
Shakeel Ahmed Ansari ◽  
Rukhsana Satar ◽  
Mohammad Alam Jafri ◽  
Mahmood Rasool ◽  
Waseem Ahmad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy
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