scholarly journals Genetic Biomarker Selection for Obsessive-Compulsive Disorder by Sparse Representation Based Variable Selection Method

2016 ◽  
Keyword(s):  
Variable Selection ◽  
Sparse Representation ◽  
Obsessive Compulsive Disorder ◽  
Selection Method ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Variable Selection Method ◽  
Selection For ◽  
Genetic Biomarker ◽  
Biomarker Selection

Variable selection for random effects two-part models

2018 ◽  
Vol 28 (9) ◽  
pp. 2697-2709 ◽  
Author(s):  
Dongxiao Han ◽  
Lei Liu ◽  
Xiaogang Su ◽  
Bankole Johnson ◽  
Liuquan Sun
Keyword(s):  
Variable Selection ◽  
Random Effects ◽  
Information Criterion ◽  
Selection Method ◽  
Sparse Estimation ◽  
Variable Selection Method ◽  
Zero Values ◽  
Selection For ◽  
And Storage ◽  
Proc Nlmixed

Random effects two-part models have been applied to longitudinal studies for zero-inflated (or semi-continuous) data, characterized by a large portion of zero values and continuous non-zero (positive) values. Examples include monthly medical costs, daily alcohol drinks, relative abundance of microbiome, etc. With the advance of information technology for data collection and storage, the number of variables available to researchers can be rather large in such studies. To avoid curse of dimensionality and facilitate decision making, it is critically important to select covariates that are truly related to the outcome. However, owing to its intricate nature, there is not yet a satisfactory variable selection method available for such sophisticated models. In this paper, we seek a feasible way of conducting variable selection for random effects two-part models on the basis of the recently proposed “minimum information criterion” (MIC) method. We demonstrate that the MIC formulation leads to a reasonable formulation of sparse estimation, which can be conveniently solved with SAS Proc NLMIXED. The performance of our approach is evaluated through simulation, and an application to a longitudinal alcohol dependence study is provided.

Sign in / Sign up

Export Citation Format

Share Document